Evaluation of D-Dimer and Neutrophil/Lymphocyte Ratios of COVID-19 Patients Whom Applied to Karapınar State Hospital

Yıl 2022, Cilt: 12 Sayı: 4, 824 - 829, 30.12.2022

Saadet Kader , Turan Akdağ , Levent Sarıyıldız , Zeynep Özel

https://doi.org/10.33808/clinexphealthsci.1029009

Öz

Objective: The epidemic which caused by the SARS-CoV-2 virus were defined as COVID-19) and declared as a global pandemic by the World Health Organization (WHO) on March, 2020. Nowadays, many biochemical parameters related to the diagnosis and prognosis of COVID-19 are being investigated. Therefore, we aimed to evaluate D-dimer and neutrophil/lymphocyte ratios (NLR) of COVID-19 patients whom applied to Karapınar State Hospital.
Methods: Patients which consisted of 2523, whom diagnosed with COVID-19 between 11 March 2019 and 29 July 2021 at Karapınar State Hospital were included in the study. Age, gender and social history of the patients were recorded. From the results, the relationships between D-dimer and hemogram were evaluated.
Results: There was a high correlation between the variables HCT and HGB, PLT and PCT, NEUT# and WBC, and MCH and MCV (r=0.981, r=0.944, r=0.923, r=0.925). In addition, there was a high correlation between RBC and HCT and between RBC and HGB variables (r=0.852, r=0.795). There was a moderate correlation between WBC and MO#, MCHC and MCH, PDW and MPV (r=0.562, r=0.639, r=0.64). All the relationships between these variables were positive, and the value of the correlated parameter increases linearly by unit. Also, the highest positive relationships were between HCT and HGB, PLT and PCT, NEUT# and WBC, MCH and MCV. Moreover, D-dimer and NLR were not correlated (r= – 0.015, p=0.49).
Conclusion: In the study, no correlation was observed between D-dimer and neutrophil/lymphocyte ratios of COVID-19 patients. So, more comprehensive and further studies are needed to clarify these results.

Anahtar Kelimeler

COVID-19, D-dimer, neutrophil/lymphocyte ratio

Proje Numarası

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Kaynakça

• Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed 2020;91(1):157-160.
• Haider N, Rothman-Ostrow P, Osman AY, Arruda LB, Macfarlane-Berry L, Elton L. COVID-19-Zoonosis or Emerging Infectious Disease ? Front Public Health 2020;8:596944.
• Zhao Y, Nie HX, Hu K, Wu X, Zhang Y, Wang M. Abnormal immunity of non-survivors with COVID-19: predictors for mortality. Infect Dis Poverty 2020;9:108.
• Ponti G, Maccaferri M, Ruini C, Tomasi A, Ozben T. Biomarkers associated with COVID-19 disease progression. Crit Rev Clin Lab Sci 2020;57(6):389-399.
• Karataş M, Yaşar-Duman M, Tünger A, Çilli F, Aydemir Ş, Özenci V. Secondary bacterial infections and antimicrobial resistance in COVID-19: comparative evaluation of pre-pandemic and pandemic-era, a retrospective single center study. Ann Clin Microbiol Antimicrob 2021;20:51.
• Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, Escalera-Antezana JP. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis 2020;34:101623.
• Pascarella G, Strumia A, Piliego C, Bruno F, Del Buono R, Costa F. COVID-19 diagnosis and management: a comprehensive review. J Intern Med 2020;288(2):192-206.
• Rostami M, Mansouritorghabeh H. D-dimer level in COVID-19 infection: A systematic review. Expert Rev Hematol 2020;13(11):1265-1275.
• Liu X, Zhang R, He G. Hematological findings in coronavirus disease 2019: indications of progression of disease. Ann Hematol 2020;99(7):1421-1428.
• Iba T, Levy JH, Levi M, Thachil J. Coagulopathy in COVID-19. J Thromb Haemost 2020;18(9):2103-2109.
• Li Y, Deng Y, Ye L, Sun H, Du S, Huang H. Clinical Significance of Plasma D-Dimer in COVID-19 Mortality. Front Med (Lausanne) 2021;8:638097.
• Vandenberg O, Martiny D, Rochas O, van Belkum A, Kozlakidis Z. Considerations for diagnostic COVID-19 tests. Nat Rev Microbiol 2021;19(3):171-183.
• Gaffney PJ. Breakdown products of fibrin and fibrinogen: Molecular mechanisms and clinical implications. J Clin Pathol Suppl (R Coll Pathol) 1980;14:10-17.
• Halaby R, Popma CJ, Cohen A, Chi G, Zacarkim MR, Romero G et al. D-Dimer elevation and adverse outcomes. J Thromb Thromboly 2015;39(1):55-59.
• Adam SS, Key NS, Greenberg CS. D-dimer antigen: current concepts and future prospects. Blood 2009;113(13):2878-2887.
• De Monyé W, Sanson BJ, Mac Gillavry MR, Pattynama PM, Büller HR. Embolus location affects the sensitivity of a rapid quantitative D-dimer assay in the diagnosis of pulmonary embolism. J Respir Crit Care Med 2002;165(3):345-348.
• Spiezia L, Boscolo A, Poletto F, Cerruti L, Tiberio I, Campello E. COVID-19-Related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure. Thromb Haemost 2020;120(6):998-1000.
• Aloisio E, Serafini L, Chibireva M, Dolci A, Panteghini M. Hypoalbuminemia and elevated D-dimer in COVID-19 patients: a call for result harmonization. Clin Chem Lab Med 2020;58(11):e255-e256.
• Ünüvar A. COVID-19 and Coagulopathy. Journal of Advanced Studies in Health Sciences 2020;3:53-62.
• Doğan S, Bal T, Çabalak M, Dikmen N, Yaqoobi H, Ozcan O. Oxidative stress index can be a new marker related to disease severity in COVID-19. Turkish Journal of Biochemistry 2021;46(4):349-357.
• Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395(10229):1054-1062.
• Sümer Ş, Ural O, Aktuğ-Demir N. Clinical and laboratory characteristics of COVID-19 cases followed in Selcuk University Faculty of Medicine. Klimik Derg 2020;33(2):122-127.
• Yeo A, Henningham A, Fantino E. Increased susceptibility of airway epithelial cells from ataxia-telangiectasia to S. pneumoniae infection due to oxidative damage and impaired innate immunity. Sci Rep 2019;9:1-10.
• Ponti G, Maccaferri M, Ruini C, Tomasi A, Ozben T. Biomarkers associated with COVID-19 disease progression. Crit Rev Clin Lab Sci 2020;57(6):389-399.
• Guan W-J, Ni Z-Y, Hu Y, Liang W-H, Ou C-Q, He J-X. Clinical characteristics of coronavirus disease 2019 in china. N Engl J Med 2020;382:1708-1720.
• Yang A, Liu J, Tao W, Li H. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol 2020;84:106504.
• Wang J, Li Q, Yin Y, Zhang Y, Cao Y, Lin X. Excessive Neutrophils and neutrophil extracellular traps in COVID-19. Front Immunol 2020;11:2063.