ST elevasyonlu akut koroner sendromlu hastalarda artmış tiyol/disülfid oranı

Yıl 2019, Cilt: 44 Sayı: Ek 1, 20 - 25, 29.12.2019

Fatih Esad Topal , Zeynep Karakaya , Pınar Yeşim Akyol , Umut Payza , Murat Çalışkan Firdevs Topal Saliha Aksun , Serpil Erdoğan , Salim Neşelioğlu

https://doi.org/10.17826/cumj.527542

Öz

Amaç: Bu çalışmanın amacı, sağlıklı gönüllüler ile ST elevasyonlu miyokart enfarktüsü (STEMI) şikayeti ile acil servise kabul edilen hastalar arasında tiyol / disülfit hemostaz düzeylerini karşılaştırmaktır.

Gereç ve Yöntem: Bu vaka kontrol çalışması Acil Tıp Anabilim Dalı'nda yapılmıştır. Katılımcılar, 48 sağlıklı gönüllüden ve 48 hastanede yatan STEMI hastalarından oluşmaktadır. Her çalışma grubunda tiyol / disülfit seviyesi değerlendirildi. STEMI'li hastalarda Tiyol düzeylerinin (doğal/toplam) birlikteliği değerlendirildi.

Bulgular: STEMI'li hastalar ile sağlıklı gönüllüler arasında yaşlarına ve cinsiyetlerine göre anlamlı bir fark bulunmadı. Disülfit (SS) seviyelerinin her iki grupta da benzer olduğu saptandı. Gönüllülere kıyaslandığında STEMI hastalarında total tiyol (TT) ve doğal tiyol (SH) seviyelerinin çok daha düşük ve SS/TT seviyelerinin ise daha yüksek olduğu saptandı.

Sonuç: Bu çalışma, STEMI hastalarında oksidan/antioksidan oranının oksidatif tarafa kaydığını ortaya çıkarmıştır. Anormal bir tiyol/disülfit dengesi, patogenezde ve tedavi yanıtının izlenmesinde önemli bir faktör olarak düşünülebilir. Tiyol kaynakları, STEMI'nin teşhisi için kullanılabilir.

Anahtar Kelimeler

STEMI, Acute Coronary Syndrome, oxidative stress, thiol / disulphide

Increased thiol/disulphide ratio in patients with ST elevation-acute coronary syndromes

Öz

Purpose: The aim of this study was to compare thiol/disulphide haemostasis levels between healthy volunteers and the patients who were admitted to emergency with the complaint of ST Elevation myocardial infarction (STEMI).

Materials and Methods: This case-control study was carried out in the Department of Emergency Medicine. The participants consisted of 48 healthy volunteers and 48 hospitalized patients with STEMI. The thiol / disulphide level was evaluated in each study group. The association of Thiol levels (native/total) was evaluated in patients with STEMI.

Results: No significant difference was found between the patients with STEMI and healthy volunteers regarding their age or gender. The disulphide (SS) levels were similar in both groups. The total thiol (TT) and native thiol (SH) levels were much lower and the SS/TT levels were much higher in the patients with STEMI when compared with the volunteers. 

Conclusion: This study revealed that the oxidant/antioxidant ratio was shifted to the oxidative side in patients with STEMI. An abnormal thiol/disulphide state might be considered as an important factor in the pathogenesis and in monitoring the treatment response. The thiol resources may be used for diagnosis of STEMI.

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