The survival impact of adding paraaortic lymphadenectomy to pelvic lymphadenectomy in the obese endometrioid endometrial cancer cases

Yıl 2020, Cilt: 45 Sayı: 1, 134 - 140, 31.03.2020

Ghanim Khatib , Mehmet Ali Vardar , Ahmet Baris Güzel , Ümran Küçükgöz Güleç , Sevtap Seyfettinoğlu , Berin Bayat Emine Bağır , Semra Paydaş

https://doi.org/10.17826/cumj.631216

Öz

Purpose: The aim of this study was to investigate the survival impact of adding paraaortic lymphadenectomy to pelvic lymphadenectomy in the obese low-grade endometrioid endometrial cancer cases.
Materials and Methods: The pathology reports, computer records and archival files of the operated endometrial cancer cases were retrospectively reviewed. During this period, among patients with full data, those who had low-grade endometrioid type and Body Mass Index (BMI) >30 kg/m2 were determined. From these cases, merely those who underwent lymph node dissection were included in this study. Patients were divided into two groups; only pelvic lymphadenectomy and pelvic-paraaortic lymphadenectomy. Groups’ demographic, clinical, surgical, follow-up survival data were analyzed and compared.
Results: 290 patients were designated, among them 207 cases who did not undergo lymph node dissection were excluded and therefore study was conducted with 34 patients in the pelvic lymphadenectomy group and 49 in the pelvic-paraaortic lymphadenectomy group. Clinical, surgical and pathological features of both groups were similar. Five-year disease-free survival rate was 80% and 86.3%, while 5-year overall survival rate was 92.6% and 86.3%, respectively.
Conclusion: In case of lymph node dissection was planned to this particular population of the current study, we think that adding paraaortic lymphadenectomy to the pelvic lymph node dissection, may will not contribute to the survival. 

Anahtar Kelimeler

Obesity, endometrial cancer, survival

Obez endometroid endometrial kanserli olgulara pelvik lenfadenektomiye paraaortik lenfadenektomi eklenmesinin sağkalıma etkisi

Öz

Amaç: Bu çalışmada obez düşük grade endometroid endometrial kanserde pelvik lenfadenektomiye paraaortik lenfadenektomi eklenmesinin sağkalıma olan etkisini araştırmaya amaçlanmıştır.
Gereç ve Yöntem: Opere edilen endometrium kanserlerinin patoloji raporları ve birimin bilgisayar kayıtları ile arşiv dosyaları retrospektif bir şekilde tarandı. Bu süre içerisinde tüm bilgilerine ulaşılabilen hastalardan, Vücut Kitle İndeksi (VKİ) >30 kg/m2 ve endometroid histolojiye sahip olan hastalar tespit edildi. Bu vakalardan sadece lenf nodu diseksiyonu yapılmış olanlar çalışmaya dahil edildi. Hastalar uygulanan lenfadenektomiye göre iki gruba ayrıldı; sadece pelvik lenfadenektomi ve pelvik-paraaortik lenfadenektomi. Grupların demografik, klinik, cerrahi, patolojik, takip ve sağkalım bilgileri analiz edilip karşılaştırıldı.
Bulgular: Çalışmanın kriterlerine uygun 290 hasta tespit edildi, bunlardan lenf nodu diseksiyonu uygulanmayan 207 vaka çıkarıldıktan sonra, çalışma pelvik lenfadenektomi grubunda 34 ve pelvik-paraaortik lenfadenektomi grubunda 49 hasta ile yürütüldü. Genel olarak her iki grubun klinik, cerrahi ve patolojik özellikleri benzerdi. Beş yıllık hastalıksız sağkalım sırasıyla %80 ve %86.3, beş yıllık toplam sağkalım ise, %92.6 ve %86.3 idi.
Sonuç: çalışmaya alınan bu özel hasta grubunda, lenf nodu diseksiyonu planlanması halinde, pelvik lenf nodu diseksiyonuna paraaortik lenfadenektominin eklenmesi sağkalıma katkı sağlamayabileceği düşüncesindeyiz

Anahtar Kelimeler

obezite, endometroid endometrium kanseri, sağkalım

Kaynakça

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