Öz
The most common clinical symptom of HPV is the condyloma acuminata, characterized by type 6 and 11 and constitutes 90% of the infections. However, 12% of the smear specimens were found to have HPV types 16 and 18, which are actually oncogenic. This virüs which frequently infects external genitalia, infects mucocutaneous component much less frequently likewise urethra as a part of mucocutaneous component. We present a case of A 58-year-old menapousal woman consulted with gynecological and obstetrics department due to pathology report of condyloma accumunata of previously excited mass from anal region by a general surgeon. At the examination of the patient, two white clitoral condyloma with white colored tiny condyloma on the right side of the urethra were seen, both HPV 16 and 18 were detected aftetwards. Urethral condyloma acuminata of atypical location at urethral mucosa which coincided with vulvar condyloma, can be a clue for oncogenic HPV infection. We aimed to discuss the mucosal involvement of HPV which is rarer but has a high probability of being oncogenic
Anahtar Kelimeler
Kaynakça
- Simms I, Fairley CK. Epidemiology of genital warts in England and Wales: 1971 to 1994. Genitourin Med. 1997;73:365-7.
- Cinar O, Suat Bolat M, Akdeniz E, Sahinkaya N. A rare cause of acute urinary retention in women: meatal condyloma accuminata, a case report. Pan Afr Med J. 2016;27:24-87.
- Iuliano M, Mangino G, Chiantore MV, Zangrillo MS, Accardi R, Tommasino M et al. Human Papillomavirus E6 and E7 oncoproteins affect the cell microenvironment by classical secretion and extracellular vesicles delivery of inflammatory mediators Cytokine. 2018;106:182-89.
- Dupin N. Genital warts. Clin Dermatol. 2004;22:481-6.
- Rabaan AA, Alfaraj SA, Alkhalifah MA. Comparison of the Cepheid Xpert HPV test and the HC2 High Risk HPV DNA Test for detection of high risk HPV infection in cervical smear samples in SurePath preservative fluid. J Med Microbiol. 2018;67:676-80.
- Fletcher SG, Lemack GE. Benign masses of the female periurethral tissues and anterior vaginal wall. Curr Urol Rep. 2008;9:389-96.
- Wiley DJ, Douglas J, Beutner K, Cox T, Fife K et al. External genital warts: diagnosis, treatment, and prevention. Clin Infect Dis 2002;35:210-24.
- Brown DR, Bryan JT, Cramer H,Fife KH. Analysis of human papillomavirus types in exophytic condyloma acuminata by hybrid capture and Southern blot techniques. J Clin Microbiol. 1993;31:2667-73.
- Bruni L, Barrionuevo-Rosas L, Albero G, Aldea M, Serrano B et al. ICO Information Centre on HPV and Cancer (HPV Information Centre). Human papillomavirus and related diseases in the world: Summary report. December 15, 2016. http://www.hpvcentre.net/statistics/reports/XWX.pdf (Accessed on April 13, 2017.)
Öz
Human Papilloma Virüs( HPV) enfeksiyonun en sık klinik bulgusu kondiloma akümunatadır, Genital HPV enfeksiyonlarının yaklaşık % 90'ını oluşturur ve HPV tip 6 ve 11 ile karakterizedir. fakat, bu hastaların servikal yayma preparatlarına bakıldığında % 12' sinde onkojenik tipler olan HPV tip 16 ve 18 pozitifliği söz konusudur. Sıklıkla dış genitalyayı enfekte eden bu virüs daha nadir olarak mukokütenöz yüzeyleri de enfekte edebilmektedir ve üretra da mukokütenöz yüzeyin bir parçası olması sebebiyle enfekte olabilmektedir. Genel cerrahi tarafından perianal kitle eksize edilen ve patoloji sonucu kondilom olarak gelmesi üzerine jinekolojik konsultasyon istenen 58 yaşında mennapoz döneminde olan hastayı sunmaktayız. Hastanın jinekolojik muayenesinde 2 adet beyaz klitoral ve üretranın sağ sınırını oluşturan1 adet minik beyaz kondilom izlendi ve muayene sırasında alınan sürüntü örneğinde ise HPV 16 ve 18 pozitifliği saptandı. Üretral mukoza gibi atipik yerleşimli ve eş zamanlı vulvar kondilomu olan üretral kondiloma akümünatanın tespit edilmesi onkojenik HPV enfeksiyonlarının mukozal tropizmi sebebi ile, onkojenik surşların enfeksiyonunun araştırılması için bir ipucu olabilir. Vakamız eşliğinde HPV’nin daha nadir fakat onkojenik olma ihtiali yüksek mukozal tutulu tartışmayı amaçladık.
Anahtar Kelimeler
Kaynakça
- Simms I, Fairley CK. Epidemiology of genital warts in England and Wales: 1971 to 1994. Genitourin Med. 1997;73:365-7.
- Cinar O, Suat Bolat M, Akdeniz E, Sahinkaya N. A rare cause of acute urinary retention in women: meatal condyloma accuminata, a case report. Pan Afr Med J. 2016;27:24-87.
- Iuliano M, Mangino G, Chiantore MV, Zangrillo MS, Accardi R, Tommasino M et al. Human Papillomavirus E6 and E7 oncoproteins affect the cell microenvironment by classical secretion and extracellular vesicles delivery of inflammatory mediators Cytokine. 2018;106:182-89.
- Dupin N. Genital warts. Clin Dermatol. 2004;22:481-6.
- Rabaan AA, Alfaraj SA, Alkhalifah MA. Comparison of the Cepheid Xpert HPV test and the HC2 High Risk HPV DNA Test for detection of high risk HPV infection in cervical smear samples in SurePath preservative fluid. J Med Microbiol. 2018;67:676-80.
- Fletcher SG, Lemack GE. Benign masses of the female periurethral tissues and anterior vaginal wall. Curr Urol Rep. 2008;9:389-96.
- Wiley DJ, Douglas J, Beutner K, Cox T, Fife K et al. External genital warts: diagnosis, treatment, and prevention. Clin Infect Dis 2002;35:210-24.
- Brown DR, Bryan JT, Cramer H,Fife KH. Analysis of human papillomavirus types in exophytic condyloma acuminata by hybrid capture and Southern blot techniques. J Clin Microbiol. 1993;31:2667-73.
- Bruni L, Barrionuevo-Rosas L, Albero G, Aldea M, Serrano B et al. ICO Information Centre on HPV and Cancer (HPV Information Centre). Human papillomavirus and related diseases in the world: Summary report. December 15, 2016. http://www.hpvcentre.net/statistics/reports/XWX.pdf (Accessed on April 13, 2017.)
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Editöre Mektup |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Mart 2022 |
| Kabul Tarihi | 7 Aralık 2021 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 47 Sayı: 1 |
