Geri Çekildi: Effect of curcumin on rat sublingual gland exposed to cyclophosphamide

Yıl 2022, Cilt: 47 Sayı: 2, 1 - 1, 30.06.2022

Ahmad Yahyazadeh

Bu makale geri çekilmiştir. https://dergipark.org.tr/tr/pub/cumj/issue/62102/895357

Geri Çekme Notu

The article with doi number 10.17826/cumj.895357, which was published in the 3rd issue with a reference of 2021;46(3):897-903, has been withdrawn from publication in accordance with the author's withdrawal request.

Öz

Purpose: This study investigated the effect of cyclophosphamide (CY) on the sublingual glands of 12 weeks old rats, as well as possible efficacy of curcumin (CR) on morphometrical change in these tissues.
Materials and Methods: Thirty-five adult male Wistar albino rats were randomly selected and divided into five group of seven rats as: control (Con), olive (OV), CY, CR, and CY+CR. The mean volumes of sublingual gland structures and the number of mucous and serous cells were estimated using stereological method.
Results: We found that the number of mucous and serous cells was significantly decreased in the CY group than the Con group. The total volume of mucous acini, serous acini, and intercalated ducts, as well volume fraction ratio of mucous acini to stroma was significantly decreased in the CY group than the Con group. By the contrary, there was a significant increase in the total volume of stroma in the CY group when compared with the Con group). In the CY+CR group, the number of mucous cells and serous cells was significantly higher than the CY group.
Conclusion: We speculated that CY treatment caused a detrimental effect on the sublingual gland tissues, and that administration of CR also ameliorated the changes induced by CY.

Anahtar Kelimeler

Cyclophosphamide, curcumin, sublingual gland, rat

Geri Çekildi: Siklofosfamide maruz kalmış sıçanların dilaltı bezi üzerine kurkuminin etkisi

Bu makale geri çekilmiştir. https://dergipark.org.tr/tr/pub/cumj/issue/62102/895357

Geri Çekme Notu

Dergimizin 2021 yılı 3. sayısında 2021;46(3):897-903 künyesi ile yayınlanmış olan 10.17826/cumj.895357 doi nolu makalenin, yazarın geri çekme isteği doğrultusunda yayından geri çekilmesi uygun bulunmuştur.

Öz

Amaç: Bu çalışma, siklofosfamidin (CY) 12 haftalık sıçanların dil altı bezleri üzerindeki etkisini ve ayrıca kurkuminin (CR) bu dokulardaki olası morfometrik değişimi üzerindeki olası etkinliğini araştırdı.
Gereç ve Yöntem: Otuz beş yetişkin erkek Wistar albino sıçan rastgele seçilerek aşağıdaki gibi yedi sıçandan oluşan beş gruba ayrıldı: kontrol (Con), zeytin (OV), CY, CR ve CY + CR. Dil Dil altı bez yapılarının ortalama hacimleri ve müköz ve seröz hücre sayısı stereolojik yöntemi kullanılarak tahmin edildi.
Bulgular: CY grubundaki mükös hücre ve seröz hücre sayısı, Con grubuna göre anlamlı olarak azaldığını bulduk. Ayrıca CY grubundaki mükös asinüsler, seröz asinüsler ve interkalat kanalların toplam hacmileri ile mükös asinüslerin stromaya hacim fraksiyon oranı, Con grubuna göre anlamlı olarak azalmıştı. Buna ek olarak, Con grubuna kıyasla CY grubunda toplam stroma hacminde anlamlı ölçüde bir artış gözlemlendi. CY+CR grubundaki müköz hücre ve seröz hücre sayısı, Con grubuna göre anlamlı olarak artmıştır.
Sonuç: CY tedavisinin dil altı bezleri üzerinde zararlı bir etkiye neden olduğunu ve CR uygulamasının da CY'nin neden olduğu değişiklikleri iyileştirdiğini düşündük.

Anahtar Kelimeler

Dilaltı bezi, kurkumin, rat, siklofosfamid

Kaynakça

• 1. Şengül E, Gelen V, Gedikli S, Özkanlar S, Gür C, Çelebi F, et al. The protective effect of quercetin on cyclophosphamide-Induced lung toxicity in rats. Biomed Pharmacother. 2017;92:303-7.
• 2. Doustimotlagh AH, Kokhdan EP, Vakilpour H, Khalvati B, Barmak MJ, Sadeghi H, et al. protective effect of Nasturtium officinale R. Br and quercetin against cyclophosphamide-induced hepatotoxicity in rats. Mol Biol Rep. 2020;47:5001-12.
• 3. Temel Y, Kucukler S, Yıldırım S, Caglayan C, Kandemir FM. Protective effect of chrysin on cyclophosphamide-induced hepatotoxicity and nephrotoxicity via the inhibition of oxidative stress, inflammation, and apoptosis. Naunyn Schmiedebergs Arch Pharmacol. 2020;393:325-37.
• 4. Singh S, Kumar A. Protective Effect of Edaravone on Cyclophosphamide Induced Oxidative Stress and Neurotoxicity in Rats. Curr Drug Saf. 2019;14:209-16.
• 5. Shruthi S, Bhasker Shenoy K. Gallic acid: A promising genoprotective and hepatoprotective bioactive compound against cyclophosphamide induced toxicity in mice. Environ Toxicol. 2020;36:123-31.
• 6. Iqubal A, Iqubal MK, Sharma S, Ansari MA, Najmi AK, Ali SM, et al. Molecular mechanism involved in cyclophosphamide-induced cardiotoxicity: Old drug with a new vision. Life Sci. 2019;218:112-31.
• 7. Soleimani V, Sahebkar A, Hosseinzadeh H. Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review. Phytother Res. 2018;32:985-95.
• 8. Hu S, Xu Y, Meng L, Huang L, Sun H. Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells. Exp Ther Med. 2018;16(2):1266-72.
• 9. Guo W, Wu X, Li Y, Gao J, Wang F, Jin Y, et al. Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancer. J Drug Target. 2020;28:41-5.
• 10. Pricci M, Girardi B, Giorgio F, Losurdo G, Ierardi E, Di Leo A. Curcumin and Colorectal Cancer: From Basic to Clinical Evidences. Int J Mol Sci. 2020;21:2364.
• 11. Li W, Sun L, Lei J, Wu Z, Ma Q, Wang Z. Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor-stromal crosstalk under hypoxic conditions via the IL-6/ERK/NF-kappaB axis. Oncol Rep. 2020;44:382-92.
• 12. Akomolafe SF, Olasehinde TA, Oyeleye SI, Aluko TB, Adewale OO, Ijomone OM. Curcumin Administration Mitigates Cyclophosphamide-Induced Oxidative Damage and Restores Alteration of Enzymes Associated with Cognitive Function in Rats' Brain. Neurotox Res. 2020;38:199-210.
• 13. Abraham P, Isaac B. The effects of oral glutamine on cyclophosphamide-induced nephrotoxicity in rats. Hum Exp Toxicol. 2011;30:616-23. 14. Xiong ZE, Dong WG, Wang BY, Tong QY, Li ZY. Curcumin attenuates chronic ethanol-induced liver injury by inhibition of oxidative stress via mitogen-activated protein kinase/nuclear factor E2-related factor 2 pathway in mice. Pharmacogn Mag. 2015;11:707-15.
• 15. Yahyazadeh A, Altunkaynak BZ, Alkan I. The morphometrical and immunohistochemical investigation of the effect of topiramate on liver and the role of neuropeptide Y receptor in an obese female rat. Bratisl Lek Listy. 2020;121:656-62.
• 16. Yahyazadeh A, Altunkaynak BZ. Effect of luteolin on biochemical, immunohistochemical, and morphometrical changes in rat spinal cord following exposure to a 900 mhz electromagnetic field. Biomed Environ Sci. 2020;33:593-602.
• 17. Yahyazadeh A, Altunkaynak BZ. Neuroprotective efficacy of luteolin on a 900-MHz electromagnetic field-induced cerebellar alteration in adult male rat. Brain Res. 2020;1744:146919.
• 18. Yahyazadeh A, Altunkaynak BZ, Kaplan S. Biochemical, immunohistochemical and morphometrical investigation of the effect of thymoquinone on the rat testis following exposure to a 900-MHz electromagnetic field. Acta Histochem. 2020;122:151467.
• 19. Altunkaynak BZ, Yahyazadeh A. Stereological and Histological Assessment of the Umbilical Cord in New Born Rat 2021. Ahead of print. 10.4103/JMAU.JMAU_14_20.
• 20. Yahyazadeh A, Altunkaynak BZ. Investigation of the neuroprotective effects of thymoquinone on rat spinal cord exposed to 900 MHz electromagnetic field. J Chem Neuroanat. 2019;100:101657.
• 21. Gundersen HJ, Jensen EB. The efficiency of systematic sampling in stereology and its prediction. J Microsc.1987;147:229–63.
• 22. Ding H, Chen J, Su M, Lin Z, Zhan H, Yang F, et al. BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis. J Neuroinflammation. 2020;17:19.
• 23. Gunes S, Ayhanci A, Sahinturk V, Altay DU, Uyar R. Carvacrol attenuates cyclophosphamide-induced oxidative stress in rat kidney. Can J Physiol Pharmacol. 2017;95:844-49.
• 24. Virag L, Szabo E, Gergely P, Szabo C. Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention. Toxicol Lett. 2003;140-141:113-24.
• 25. Hanukoglu I. Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells. Drug Metab Rev. 2006;38:171–96.
• 26. Yahyazadeh A, Deniz ÖG, Kaplan AA, Altun G, Yurt KK, Davis D. The genomic effects of cell phone exposure on the reproductive system. Enviro Res. 2018;167:684-93.
• 27. Kim KS, Lim HJ, Lim JS, Son JY, Lee J, Lee BM, et al. Curcumin ameliorates cadmium-induced nephrotoxicity in Sprague-Dawley rats. Food Chem Toxicol. 2018;114:34–40.
• 28. Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, et al. Biological activities of curcumin andits analogues (congeners) made by man and Mother Nature. Biochem Pharmacol. 2008;76:1590–611.
• 29. Avci H, Epikmen ET, Ipek E, Tunca R, Birincioglu SS, Akşit H, et al. Protective effects of silymarin and curcumin on cyclophosphamide-induced cardiotoxicity. Exp Toxicol Pathol. 2017;69:317-27.
• 30. Iqubal A, Sharma S, Ansari MA, Najmi AK, Syed MA, Ali J, et al. Nerolidol attenuates cyclophosphamide-induced cardiac inflammation, apoptosis and fibrosis in Swiss Albino mice. Eur J Pharmacol. 2019;863:172666.
• 31. Patwa J, Khan S, Jena G. Nicotinamide attenuates cyclophosphamide-induced hepatotoxicity in SD rats by reducing oxidative stress and apoptosis. J Biochem Mol Toxicol. 2020;34:e22558.
• 32. Giordano A, Tommonaro G. Curcumin and Cancer. Nutrients. 2019;11:2376.