Expression of nuclear pore protein POM121 in childhood acute lymphoblastic leukemias and its relationship with prognosis

Yıl 2023, Cilt: 48 Sayı: 1, 64 - 71, 31.03.2023

Burcu Genç Cavlak , Ayşe Özkan , İbrahim Bayram , Gülay Sezgin , Serhan Küpeli , Atila Tanyel,i

https://doi.org/10.17826/cumj.1179379

Öz

Purpose: We aimed to investigate the status of POM121 gene expression, which is one of the nuclear pore proteins in childhood acute lymphoblastic leukemias (ALL), compared with the normal population, and its relationship with prognosis and other clinical findings.
Materials and Methods: Fifty-nine patients with ALL followed up and treated between January 2008 and November 2013, and 36 control subjects were included in the study. A real-time PCR method was used to detect POM121 gene expressions.
Results: The mean value of POM121 expression was 3.75±2.91 in ALL patients and 3.32±3.76 in the control group. The 3 and 10 year overall survival (OS) was better in ALL with lower POM121 expression (77%, 70% versus 68%, 58%, respectively). Although the OS was better in B-ALL patients, with lower POM121 expression (84%, 75% versus 54%, 46%, respectively), in T-ALL, in contrast, the OS results were better in patients with a higher POM121 expression (90%, 90% versus 60%, 60%, respectively). Patients with a higher POM121 expression than the mean of the control group and who had relapse and central nervous system involvement had statistically significantly lower OS results in the 3rd and 10th years (16%, 0% versus 84%, 78%, respectively).
Conclusion: High POM121 expression negatively affects the prognosis in patients with ALL. This is a study to show the relationship between POM121 expression and prognosis in childhood acute lymphoblastic leukemias, POM121 function will be clarified further with more comprehensive studies.

Anahtar Kelimeler

Acute lymphoblastic leukemia, POM121 expression, prognosis

Destekleyen Kurum

Cukurova University Research Projects Funding Unit

Proje Numarası

TF2013 LTP30

Teşekkür

This work was supported by ‘Cukurova University Research Projects Funding Unit’ with Project number TF2013 LTP30.

Çocukluk çağı akut lenfoblastik lösemilerinde nükleer por proteini POM121’in ekspresyonu ve prognoz ile ilişkisi

Öz

Amaç: Bu çalışmada, çocukluk çağı akut lenfoblastik lösemilerinde (ALL), nükleer por proteinlerinden biri olan POM121’in gen ekspresyonunun normal popülasyona göre durumunu, prognoz ve diğer klinik bulgularla ilişkisini araştırmayı amaçladık.
Gereç ve Yöntem: Ocak 2008 ile Kasım 2013 tarihleri arasında takip ve tedavi edilen 59 ALL'li hasta ve 36 kontrol olgu çalışmaya dahil edildi. POM121 gen ekspresyonunu saptamak için Real time-PCR yöntemi kullanıldı.
Bulgular: POM121 ekspresyonunun ortalama değeri ALL hastalarında 3,75 ± 2,91 ve kontrol grubunda 3,32 ± 3,76 idi. 3 ve 10 yıllık sağkalım düşük POM121 ekspresyonuna sahip olan ALL hastalarında daha iyi idi (sırasıyla %77, %70’e karşı %68, %58). B-ALL hastalarında POM121 ekspresyonu, daha düşük olan hastaların GS sonuçları daha iyi iken (sırasıyla %84, %75’e karşı %54, %46) T-ALL'de, tersine, yüksek olan hastaların GS sonuçları, daha iyi idi (sırasıyla %90, %90’a karşı %60, %60). Nüks ve merkezi sinir sistemi tutulumu olan, kontrol grubunun ortalamasından daha yüksek POM121 ekspresyonu olan hastalar 3. ve 10. yıllarda istatistiksel olarak anlamlı şekilde daha düşük GS sonuçlarına sahipti (sırasıyla %16, %0’a karşı %84, %78).
Sonuç: Yüksek POM121 ekspresyonu, ALL hastalarında prognozu olumsuz yönde etkiler. Bu çalışma, çocukluk çağı akut lenfoblastik lösemilerinde POM121 ekspresyonu ile prognoz arasındaki ilişkiyi göstermeye yönelik yapılan bir çalışmadır ve POM121’in fonksiyonlarını açığa kavuşturmak için daha kapsamlı çalışmalar gereklidir.

Anahtar Kelimeler

Akut lenfoblastik lösemi, POM121 ekspresyonu, prognoz

Proje Numarası

TF2013 LTP30

Kaynakça

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