The value of procalsitonin in determining the severity acute pancreatitis cases

Yıl 2023, , 85 - 90, 29.07.2023

Ali Zeynettin , İsmail Demir , Hüseyin Sinan Akay

https://doi.org/10.56016/dahudermj.1279501

Öz

Objectives: Many markers and indication systems are being used to indicate the prognosis of acute pancreatitis. Our study was planned to investigate the importance of procalcitonin(PCT) in patients with severe pancreatitis in terms of predicting prognosis by comparing C-reactive protein , modified CT severity index, and duration of hospitalization.
Methods: In our cross-sectional retrospective study, 30 patients who were hospitalized with a diagnosis of A. pancreatitis were included in the study. Our study was conducted from January 2013 to January 2019 at Katip Çelebi University. PCT, CRP, duration of hospitalization, gender, age, CRE, CA, pleural effusion, and modified CT severity scores were recorded in all patients.
Results: Of the 30 patients included in the study,13 (43.33%) were male and 17(56.66%) were female. The presence of stones in 80% of patients was detected in 6.7% of patients due to hypertriglestrimia. The PCT value was found to be a minimum of 0.0 ng/ml, a maximum of 39.68 ng/ml, and an average of 1.97 ng/ml. There is a significant relationship between the PCT value and the length of hospitalization for the patients. The hospitalization period was a minimum of 3 days, a maximum of 23 days, and an average of 10.13 days in the 30 patients studied. It was determined that there was a statistically significant relationship between PCT and length of stay (r = 0.437; p 0.016).
Conclusion: In patients with A. pancreatitis, the evaluation of PCT, CRP, and modified CT severity index can be used to estimate the duration of hospitalization.

Anahtar Kelimeler

Acute pancreatitis, procalcitonin, modified IT severity index, C-reactive protein

Kaynakça

• Carroll JK, Herrick B, Gipson T, Lee SP. Acute pancreatitis: diagnosis, prognosis, and treatment. Am Fam Physician. 2007 May 15;75(10):1513-20. PMID: 17555143.
• Stone HH, Fabian TC, Dunlop WE. Gallstone pancreatitis: biliary tract pathology in relation to time of operation. Ann Surg. 1981 Sep;194(3):305-12. doi: 10.1097/00000658-198109000-00008. PMID: 6168240; PMCID: PMC1345356.
• Lee DW, Cho CM. Predicting Severity of Acute Pancreatitis. Medicina (Kaunas). 2022 Jun 11;58(6):787. doi: 10.3390/medicina58060787. PMID: 35744050; PMCID: PMC9227091.
• Herrmann MG, Dobrowolski SF, Wittwer CT. Rapid beta-globin genotyping by multiplexing probe melting temperature and color. Clin Chem. 2000 Mar;46(3):425-8. Erratum in: Clin Chem. 2004 Jun;50(6):1111. Erratum in: Clin Chem. 2004;50(5):982. PMID: 10702535.
• Rau B, Steinbach G, Gansauge F, Mayer JM, Grünert A, Beger HG. The potential role of procalcitonin and interleukin 8 in the prediction of infected necrosis in acute pancreatitis. Gut. 1997 Dec;41(6):832-40. doi: 10.1136/gut.41.6.832. PMID: 9462219; PMCID: PMC1891610.
• Huang QL, Qian ZX, Li H. A comparative study of the urinary trypsinogen-2, trypsinogen activation peptide, and the computed tomography severity index as early predictors of the severity of acute pancreatitis. Hepatogastroenterology. 2010 Sep-Oct;57(102-103):1295-9. PMID: 21410075.
• Papachristou GI, Clermont G, Sharma A, Yadav D, Whitcomb DC. Risk and markers of severe acute pancreatitis. Gastroenterol Clin North Am. 2007 Jun;36(2):277-96, viii. doi: 10.1016/j.gtc.2007.03.003. PMID: 17533079.
• Mitchell RM, Byrne MF, Baillie J. Pancreatitis. Lancet. 2003 Apr 26;361(9367):1447-55. doi: 10.1016/s0140-6736(03)13139-x. PMID: 12727412.
• Warndorf MG, Kurtzman JT, Bartel MJ, Cox M, Mackenzie T, Robinson S, Burchard PR, Gordon SR, Gardner TB. Early fluid resuscitation reduces morbidity among patients with acute pancreatitis. Clin Gastroenterol Hepatol. 2011 Aug;9(8):705-9. doi: 10.1016/j.cgh.2011.03.032. Epub 2011 Apr 8. PMID: 21554987; PMCID: PMC3143229.
• Sargent S. Pathophysiology, diagnosis and management of acute pancreatitis. Br J Nurs. 2006 Oct 12-25;15(18):999-1005. doi: 10.12968/bjon.2006.15.18.22025. PMID: 17077771.
• DiMagno MJ, DiMagno EP. New advances in acute pancreatitis. Curr Opin Gastroenterol. 2007 Sep;23(5):494-501. doi: 10.1097/MOG.0b013e3282ba566d. PMID: 17762554; PMCID: PMC3474362.
• Moreau JA, Zinsmeister AR, Melton LJ 3rd, DiMagno EP. Gallstone pancreatitis and the effect of cholecystectomy: a population-based cohort study. Mayo Clin Proc. 1988 May;63(5):466-73. doi: 10.1016/s0025-6196(12)65644-4. PMID: 3361956.
• Banks PA, Freeman ML; Practice Parameters Committee of the American College of Gastroenterology. Practice guidelines in acute pancreatitis. Am J Gastroenterol. 2006 Oct;101(10):2379-400. doi: 10.1111/j.1572-0241.2006.00856.x. PMID: 17032204.
• Suppiah A, Malde D, Arab T, Hamed M, Allgar V, Smith AM, Morris-Stiff G. The prognostic value of the neutrophil-lymphocyte ratio (NLR) in acute pancreatitis: identification of an optimal NLR. J Gastrointest Surg. 2013 Apr;17(4):675-81. doi: 10.1007/s11605-012-2121-1. Epub 2013 Feb 1. PMID: 23371356.
• Kendir Ö. T. , Ağın M. , Yılmaz H. , Sarı Gökay S. , Tumgor G. Evaluation of Acute Pancreatitis Patients: Single Center Five Years’ Experience. J Contemp Med. 2021; 11(3): 262-266.
• Sargent S. Pathophysiology, diagnosis and management of acute pancreatitis. Br J Nurs. 2006 Oct 12-25;15(18):999-1005. doi: 10.12968/bjon.2006.15.18.22025. PMID: 17077771.
• Tran DD, Cuesta MA. Evaluation of severity in patients with acute pancreatitis. Am J Gastroenterol. 1992 May;87(5):604-8. PMID: 1595648.
• Singh H, Gougol A, Mounzer R, Yadav D, Koutroumpakis E, Slivka A, Whitcomb DC, Papachristou GI. Which Patients with Mild Acute Pancreatitis Require Prolonged Hospitalization? Clin Transl Gastroenterol. 2017 Dec 7;8(12):e129. doi: 10.1038/ctg.2017.55. PMID: 29215631; PMCID: PMC5746601.