Pravastatin′in Camımsı Karbon Elektrot üzerinde Kare-dalga Voltametrisi ile İlaç Formülasyonunda Tayini

Yıl 2020, Cilt: 22 Sayı: 64, 29 - 35, 24.01.2020

Pınar Talay Pınar , Tamer Tuluk Zühre Şentürk

https://doi.org/10.21205/deufmd.2020226404

Cited By: 2

Öz

Lipit
düşürücü ilaç olan Pravastatin′in, camımsı karbon elektrot üzerindeki
elektrokimyasal davranışı, Britton-Robinson tamponu içerisinde dönüşümlü
voltametri ve kare-dalga voltametrisi teknikleri kullanılarak araştırılmıştır.
Dönüşümlü voltametrik çalışmalar, molekülün tersinmez olarak yürüyen
yükseltgenmesinin difüzyon-kontrollü olduğunu göstermiştir. Kare-dalga
voltametrisi kullanılarak, Pravastatin′in pH 2.0 değerinde +1.24 V (vs.
Ag/AgCl) gerilim değerinde 2.4×10^-7-2.8×10^-6 M derişim
aralığında (saptama sınırı, 5.0×10^-8 M) tayini gerçekleştirilmiştir.
Önerilen yöntem, Pravastatin′in tablet ilaç şeklinden tayinine başarıyla
uygulanmıştır.

Anahtar Kelimeler

Pravastatin, Kare-dalga voltametrisi, Camımsı karbon elektrot

Determination of Pravastatin in Drug Formulation by Square-wave Voltammetry on a Glassy Carbon Electrode

Öz

The electrochemical behavior of
Pravastatin, a lipid-lowering drug, on a glassy carbon electrode was explored
in Britton-Robinson buffer by using cyclic and square-wave voltammetry. Cyclic
voltammetric studies indicated that the compound underwent irreversible
oxidation, which was a diffusion-controlled process. Using square-wave
voltammetry, Pravastatin could be determined at +1.24 V (vs. Ag/AgCl) in the
concentration range 2.4×10^-7-2.8×10^-6 M at pH 2.0, with a
detection limit of 5.0×10^-8 M. The suggested method was successfully
applied for the assay of Pravastatin in tablets.

Anahtar Kelimeler

Pravastatin, Square-Wave Voltammetry, Glassy Carbon Electrode

Kaynakça

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