Adverse Reactions To Blue Dye Injections During Sentinel Lymph Node Biopsy

Yıl 2017, Cilt: 31 Sayı: 2, 81 - 85, 23.08.2017

Ali İbrahim Sevinç Süleyman Özkan Aksoy Merih Güray Durak

Öz

Objective: Sentinel lymph
node biopsy for breast cancer surgical treatment has been used as an
alternative of axillary dissection in most cases. The aim of our study is to
report the rate of adverse reactions during sentinel lymph node biopsies in
early stage (T1-T2, N0, M0) breast cancer patients.

Material and method: We retrospectively reviewed 1374 consecutive SLNBs patients for early
stage breast cancer between May 1998 and April 2017 in our clinic.

Results: Blue dye was
used in SLN biopsies in 315 patients. An allergic reaction occurred in 12 of
these patients (0.4%). The patients' stay in the hospital did not change and
they received adjuvant treatment without delay.

Conclusion: Sentinel
lymph node biopsy can be performed using only radioactive colloid injection to
protect against the allergic reactions caused by the blue dye. Deep parenchymal
injections may be preferred instead of intradermal injections due to toxic
effects on the tissue in cases where blue dye should be applied.

Anahtar Kelimeler

Sentinel lymph node, blue dye, side effect

Sentinel lenf nodu örneklemesi esnasında uygulanan boya sonucunda görülen yan etkiler

Öz

Amaç: Sentinel lenf
nodu biyopsisi pek çok meme kanserli hastanın cerrahi tedavisi için aksiller
lenf nodu diseksiyonuna alternatif olarak uygulanabilir. Çalışmamızın amacı,
erken evre (T1-T2, N0, M0 ) meme kanserli hastalarda radyokolloid enjeksiyonu
ile kombine veya tek başına mavi boya kullanılarak yapılan sentinel lenf nodu
biyopsilerinde karşılaştığımız yan etkileri bildirmektir.

Gereç
ve yöntem:
Kliniğimizde erken evre meme kanseri nedeni ile Mayıs 1998 - Nisan 2017
tarihleri arasında yapılmış 1374 adet sentinel lenf nodu biyopsisi sonuçları
retrospektif olarak incelendi.

Bulgular: Sentinel lenf
nodu biyopsisi yapılan hastalardan 315 tanesinde boya kullanıldı. Bu hastaların
12 tanesinde (%0,4) alerjik reaksiyon görüldü. Hastaların hastanede kalış
sürelerinde değişiklik olmadı ve adjuvan tedavilerini gecikme olmaksızın
aldılar.

Sonuç: Mavi boyanın yol
açtığı alerjik reaksiyonlardan korunmak için sadece radyoizotop ile işlem
yapılabilir. Mavi boya uygulanması gereken olgularda ise doku üzerindeki toksik
etkilerinden ötürü intradermal enjeksiyonlar yerine derin parankimal
enjeksiyonlar tercih edilebilir.

Anahtar Kelimeler

Sentinel lenf nodu, mavi boya, yan etki

Kaynakça

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