Antiviral İlaçlardan Valasiklosir’in Surfaktan Ortamında Camımsı Karbon Elektrot ile Voltametrik Yöntemle Miktar Tayini

Yıl 2020, Cilt: 3 Sayı: 1, 50 - 59, 30.03.2019

Pınar Talay Pınar , Zühre Şentürk

Öz

Bir antiviral ilaç olan valasiklovir’in, camımsı karbon elektrot kullanarak elektrokimyasal özelliklerini anyonik yüzey aktif varlığında Britton-Robinson, fosfat tamponu ve kuvvetli asit olan 0.2 M H2SO4 çözeltilerinde araştırılmıştır. Elektrotun performansını etkileyen parametreler, destek elektrolit seçimi, pH etkisi, surfaktan etkisi ve voltametrik yöntem parametreleri detaylı bir şekilde incelenmiştir. Daha sonra geliştirilen tekniklerin elde edilen en iyi koşullarında valasiklovir için doğrusal aralık surfaktansız ortamda (10-400 µM) ve surfaktanlı ortamda (4-200 µM) ve gözlenebilme sınırı ise her iki ortamda sırasıyla 2.70 ve 1.66 µM olarak belirlenmiştir. Geliştirilen diferansiyel puls voltametri tekniği, farmasötik preparatlara uygulanmıştır.

Anahtar Kelimeler

valasiklovir, camımsı karbon elektrot, dönüşümlü voltametri, diferansiyel puls voltametrisi, surfaktan

Kaynakça

• Referans 1 Abdullah, A. A., Yardım, Y., Şentürk, Z. (2018). The performance of cathodically pretreated boron-doped diamond electrode in cationic surfactant media for enhancing the adsorptive stripping voltammetric determination of catechol-containing flavonoid quercetin in apple juice. Talanta, 187, 156-164.
• Referans 2 Brycht, M., Kaczmarska, K., Uslu, B., Ozkan, S. A., Skrzypek, S. (2016). Sensitive determination of anticancer drug imatinib in spiked human urine samples by differential pulse voltammetry on anodically pretreated boron-doped diamond electrode. Diamond and Related Materials, 68, 13-22.
• Referans 3 Devarushi, U. S., Shetti, N. P., Bukkitgar, S. D., Tuwar, S. M. (2018). Electrochemical Behavior of an Anti-Viral Drug Valacyclovir at Carbon Paste Electrode and Its Analytical Application. Russian Journal of Electrochemistry, 54(10), 760-768.
• Referans 4 Granero, G. E., Amidon, G. L. (2006). Stability of valacyclovir: implications for its oral bioavailability. International journal of pharmaceutics, 317(1), 14-18.
• Referans 5 Keskin, E., Allahverdiyeva, S., Seker, H., Yardım, Y. (2019). Simple and rapid voltammetric determination of cephalosporin drug cefixime on boron-doped diamond electrode. Monatshefte für Chemie-Chemical Monthly, 150(11), 1895-1902.
• Referans 6 Levent, A., Yardim, Y., Senturk, Z. (2009). Voltammetric behavior of nicotine at pencil graphite electrode and its enhancement determination in the presence of anionic surfactant. Electrochimica Acta, 55, 190-195.
• Referans 7 Levent, A., Onal, G. (2018). Application of a pencil graphite electrode for voltammetric simultaneous determination of ascorbic acid, norepinephrine, and uric acid in real samples. Turkish Journal of Chemistry, 42, 460 – 471.
• Referans 8 Niknezhadi, A., Nezamzadeh-Ejhieh, A. (2017). A novel and sensitive carbon paste electrode with clinoptilolite nano-particles containing hexadecyltrimethyl ammonium surfactant and dithizone for the voltammetric determination of Sn (II). Journal of colloid and interface science, 501, 321-329.
• Referans 9 Palacios, M. L., Demasi, G., Pizzorno, M. T., Segall, A. I. (2005). Validation of an HPLC method for the determination of valacyclovir in pharmaceutical dosage. Journal of Liquid chromatography & related technologies, 28(5), 751-762.
• Referans 10 Rasool, S. K., Naik, D. V., Babu, D. P., Nalluri, B. N. (2012). RP-HPLC method for the estimation of valacyclovir in bulk and pharmaceutical formulations. Int J Pharm Pharm Sci, 4(1), 214-8.
• Referans 11 Savaşer, A., Özkan, C. K., Özkan, Y., Uslu, B., Özkan, S. A. (2003). Development and validation of an RP‐HPLC method for the determination of valacyclovir in tablets and human serum and its application to drug dissolution studies. Journal of liquid chromatography & related technologies, 26(11), 1755-1767.
• Referans 12 Sugumaran, M., Bharathi, V., Hemachander, R., Lakshmi, M. (2011). RP–HPLC method for the determination of valacyclovir in bulk and pharmaceutical formulation. Der Pharma Chemica, 3(4), 190-194.
• Referans 13 Talay Pınar, P. (2006). Antiviral ilaçlardan Asiklovir ve Valasiklovir’in voltametrik yöntemle miktar tayini. Yayımlanmamış Yüksek Lisans Tezi. Van Yüzüncü Yıl Üniversitesi, Fen Bilimleri Enstitüsü, Van.
• Referans 14 Talay Pınar, P., Senturk, Z. (2017). Voltammetric investigation of antiviral drug valacyclovir at a boron-doped diamond electrode in different electrolyte media: its determination enhanced by anionic surfactant in pharmaceuticals and biological fluids. Current Pharmaceutical Analysis, 13(2), 175-187.
• Referans 15 Talay Pınar, P., Yardım, Y., Şentürk, Z. (2018). Electrochemical oxidation of ranitidine at poly(dopamine) modified carbon paste electrode: Its voltammetric determination in pharmaceutical and biological samples based on the enhancement effect of anionic surfactant. Sensors and Actuators: B. Chemical, 273, 1463-1473.
• Referans 16 Talay Pınar, P., Ali, H. S., Abdullah, A. A., Yardım, Y., Şentürk, Z. (2018). Electroanalytical determination of salbutamol in pharmaceutical formulations using cathodically pretreated boron-doped diamond electrode. Marmara Pharmaceutical Journal, 22, 460-468.
• Referans 16 Tarinc, D., Golcu, A. (2015). Electrochemical behavior of valacyclovir and its square wave and differential pulse voltammetric determination in pharmaceuticals and biological fluids. Russian Journal of Electrochemistry, 51(2), 149-158.
• Referans 17 Uslu, B., Özkan, S. A., Şentürk, Z. (2006). Electrooxidation of the antiviral drug valacyclovir and its square-wave and differential pulse voltammetric determination in pharmaceuticals and human biological fluids. Analytica chimica acta, 555(2), 341-347.
• Referans 18 Wang, J., 2000. Analytical Electrochemistry. 2nd Ed. Wiley-VCH, New York. S.1- 209.
• Referans 19 Yardım, Y., Levent, A., Keskin, E., Şentürk, Z. (2011). Voltammetric behavior of benzo[a]pyrene at borondoped diamond electrode: A study of its determination by adsorptive transfer stripping voltammetry based on the enhancement effect of anionic surfactant, sodium dodecylsulfate. Talanta, 85, 441-448.