Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department

Yıl 2017, Cilt: 44 Sayı: 2, 175 - 182, 07.06.2017

Ali Kemal Erenler , Derya Yapar Özlem Terzi

https://doi.org/10.5798/dicletip.319750

Cited By: 2

Öz

Objective: Sepsis and severe sepsis (sepsis accompanied by acute organ dysfunction) are leading causes of death
worldwide. In this study, our aim was to investigate utility of biomarkers commonly used in diagnosis of sepsis in
discriminating these two entities.
Methods: Two-hundred and three patients involved were divided into 2 subgroups as sepsis and severe sepsis
according to Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock:
2012. Then groups were compared according to clinical and laboratory (including C-reactive protein (CRP) and
procalcitonin (PCT) levels) characteristics.
Results: Of 203 patients included into the study, 124 (61.1%) were male and 79 (38.9%) were female. The most
common reason for sepsis was urinary tract infection (n=64, 31.5%), followed by catheter infection (n=16, 7.9%) and
pneumonia (n=14, 6.9%). Escherichia coli was the most common agent in both blood and urinary cultures. Majority of
the patients were treated with ceftriaxone (n=33, 16.3%), followed by meronem/dapson (n=25, 12.3%). In both
groups, CRP and PCT levels were high, even higher in severe sepsis group. However, any statistical significance could
not be determined between groups. Mortality rate in sepsis patients was 6.4%.
Conclusion: Plasma levels of both markers elevate in sepsis and severe sepsis. It was determined that CRP and PCT is
higher in severe sepsis than in sepsis. However, the difference is not statistically significant. Plasma levels of CRP and
PCT are not useful in differential diagnosis of sepsis and severe sepsis.

Anahtar Kelimeler

C-reactive protein, procalcitonin, sepsis, severe sepsis

Kaynakça

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