Öz
Objective: Arsenic is a metal with a widespread industrial usage and causing oxidative stress. Studies shows serum uric acid and gamma gluthamyl transferase (GGT) levels are increasing in oxidative stress. The aim of this study is to evaluate the effect of arsenic exposure on serum uric acid and GGT levels.Methods: 500 patients who refer to Ankara Occupational Disease Hospital between 2010 to 2014 for periodic examination and urinary arsenic, serum uric acid and serum GGT levels assessed are included in this study. 268 patients with urinary arsenic levels over 35μg/L are defined as exposed and below 35μg/L are controls.Results: Data of 500 patients were analysed. 268 of them had high urine arsenic levels and 232 had normal urine arsenic levels. In the high urine arsenic level group the median serum uric acid level was 5.4 (2.60-7.20) and median serum GGT level was 27 in the other group with normal urine arsenic levels the median serum uric acid level was 4.9 and median serum GGT level was 22 . The difference between two groups was statistically significant (p value: 0.002 and <0.001 respectively)Conclusion: Arsenic exposure may be associated with hyperuricemia and high levels of GGT and with prospective studies the causal relationship between arsenic exposure and hyperuricemia and GGT can be revealed
Anahtar Kelimeler
Kaynakça
- Mandal BK, Suzuki KT. Arsenic round the world: a review.
- Talanta 2002;58:201-235.
- Flora SJ. Arsenic-induced oxidative stress and its reversibil
- ity. Free Radic Biol Med 2011;15:257-281.
- Bhattacharjee S, Sarkar C, Pal S. Additive beneficial effect
- of folic acid and vitamin b12 co-administration on arsenic-
- induced oxidative damage in cardiac tissue in vivo. Asian J
- Pharm Clin Res 2013;6:64-69.
- Nan H, Dong Y, Gao W, et al. Diabetes associated with a
- low serum uric acid level in a general Chinese population.
- Diabetes Res Clin Pract 2007;76:68–74.
- Yildirim A, Altinkaynak K, Aksoy H, et al. Plasma xanthine
- oxidase, superoxide dismutase and glutathione peroxidase
- activities and uric acid levels in severe and mild pre-eclampsia. Cell Biochem Funct 2004;22:213–217.
- Akbaş ME, Özçiçek A, Özçiçek F. Metabolik olarak sağlıklı
- ve sağlıksız obez hastalarda ürik asit seviyeleri. Dicle Tıp
- Dergisi 2014;41:676-680.
- Whitfield JB. Gamma glutamyl transferase. Crit Rev Clin
- Lab Sci 2001;38:263-355.
- Jones DP, Carlson JL, Mody VC, et al. Redox state of glutathione in human plasma. Free Radic Biol Med 2000;
- :625-635.
- Lee DH, Blomhoff R, Jacobs DR Jr. Is serum gamma glutamyltransferase a marker of oxidative stress? Free Radic Res 2004;38:535-539.
- Abdul-Rasheed OF, Al-Shamma GA, Zillo BH. Serum γ-glutamyltransferase as Oxidative Stress Markerin Pre-and Postmenopausal Iraqi Women. Oman Med J 2010;25:286-288.
- ACGIH Monograph. TLVs and BEIs, threshold limit values
- for chemical substances and physical agents and biological
- exposure indices. Cincinnati, OH: Signature Publications, 2011:122.
- Casale T, Rosati MV, Ciarrocca M, et al. Assessment of
- liver function in two groups of outdoor workers exposed to
- arsenic. Int Arch Occup Environ Health 2014;87:745-752.
- Kuo CC, Weaver V, Fadrowski JJ, et al. Arsenic exposure, hyperuricemia, and gout in US adults. Environ Int 2015;76:32-34.
- Robles-Osorio ML, Pérez-Maldonado IN, Martín del Campo D, et al. Urinary arsenic levels and risk of renal injury in a cross-sectional study in open population. Rev Invest Clin 2012;64:609-614.
- Mershiba SD, Dassprakash MV, Saraswathy SD. Protective
- effect of naringenin on hepatic and renal dysfunction and
- oxidative stress in arsenic intoxicated rats. Mol Biol Rep
- ;40:3681-3691.
- Yao ML, Zhang AH, Yu C, et al. The establishment of the
- arsenic poisoning rats model caused by corn flour baked
- by high-arsenic coal. Zhonghua Yu Fang Yi Xue Za Zhi
- ;47:799-805.
- Casale T, Rosati MV, Ciarrocca M, et al. Assessment of
- liver function in two groups of outdoor workers exposed to
- arsenic. Int Arch Occup Environ Health 2014;87:745-752.
- Lee DJ, Choi JS, Kim KM, et al. Combined effect of serum
- gamma-glutamyl transferase and uric acid on Framingham
- risk score. Arch Med Res 2014;45:337-342.
- Kim KM, Kim BT, Lee DJ, et al. Serum gamma-glutamyl transferase as a risk factor for general cardiovascular disease
- prediction in Koreans. J Investig Med 2012;60:1199-1203.
- Kong AP, Choi KC, Ho CS, et al. Associations of uric acid
- and gamma-glutamyltransferase (GGT) with obesity and
- components of metabolic syndrome in children and adolescents. Pediatr Obes 2013;8:351-357.
- Long Y, Zeng F, Shi J, et al. Gamma-glutamyltransferase
- predicts increased risk of mortality: a systematic review
- and meta-analysis of prospective observational studies.
- Free Radic Res 2014;48:716-728.
Arsenik maruziyeti olan kişilerde serum gama glutamil transferaz ve ürik asit düzeylerinin değerlendirilmesi
Öz
Amaç: Arsenik endüstride oldukça yaygın kullanılan ve oksidatif strese neden olduğu bilinen bir metaldir. Serum ürik asit ve gama glutamil transferaz (GGT) düzeylerinin oksidatif stres durumunda arttığını gösteren çalışmalar bulunmaktadır. Bu çalışmanın amacı arsenik maruziyetinin serum ürik asit ve GGT düzeylerine etkisinin araştırılmasıdır.
Yöntemler: 2010-2014 yılları arasında Ankara Meslek Hastalıkları Hastanesine periyodik muayene amaçlı başvuran idrar arsenik, serum ürik asit ve GGT düzeylerine bakılmış 500 kişi çalışmaya dahil edildi. İdrar arsenik düzeyi 35μg/L’nin üzerinde çıkan 268 kişi arsenik maruz grup, 35μg/L’nin altında çıkan 232 kişi ise kontrol grubu olarak kullanıldı.
Bulgular: Arsenik maruz grubun median serum ürik asit değerleri 5,4 (2,60-7,20) median serum GGT değerleri 27 (10-51) idi. Normal idrar arsenik düzeyleri olan diğer grupta ise median serum ürik asit değerleri 4,9 (2,5-7) median serum GGT değerleri 22 (10-52) idi. İki grup arasındaki fark ürik asit ve GGT için anlamlı idi (p değerleri sırasıyla; 0,002, <0,001).
Sonuç: Arsenik maruziyeti hiperürisemi ve yüksek GGT düzeyleri ile ilişkili olabilir. Prospektif çalışmalarla, arsenik maruziyeti ile hiperürisemi, yüksek GGT düzeyleri ve klinik sonuçlar arasındaki nedensel ilişki ortaya çıkarılmalıdır.
Anahtar kelimeler: Arsenik maruziyeti, hiperürisemi, gama glutamil transferaz.
Anahtar Kelimeler
Kaynakça
- Mandal BK, Suzuki KT. Arsenic round the world: a review.
- Talanta 2002;58:201-235.
- Flora SJ. Arsenic-induced oxidative stress and its reversibil
- ity. Free Radic Biol Med 2011;15:257-281.
- Bhattacharjee S, Sarkar C, Pal S. Additive beneficial effect
- of folic acid and vitamin b12 co-administration on arsenic-
- induced oxidative damage in cardiac tissue in vivo. Asian J
- Pharm Clin Res 2013;6:64-69.
- Nan H, Dong Y, Gao W, et al. Diabetes associated with a
- low serum uric acid level in a general Chinese population.
- Diabetes Res Clin Pract 2007;76:68–74.
- Yildirim A, Altinkaynak K, Aksoy H, et al. Plasma xanthine
- oxidase, superoxide dismutase and glutathione peroxidase
- activities and uric acid levels in severe and mild pre-eclampsia. Cell Biochem Funct 2004;22:213–217.
- Akbaş ME, Özçiçek A, Özçiçek F. Metabolik olarak sağlıklı
- ve sağlıksız obez hastalarda ürik asit seviyeleri. Dicle Tıp
- Dergisi 2014;41:676-680.
- Whitfield JB. Gamma glutamyl transferase. Crit Rev Clin
- Lab Sci 2001;38:263-355.
- Jones DP, Carlson JL, Mody VC, et al. Redox state of glutathione in human plasma. Free Radic Biol Med 2000;
- :625-635.
- Lee DH, Blomhoff R, Jacobs DR Jr. Is serum gamma glutamyltransferase a marker of oxidative stress? Free Radic Res 2004;38:535-539.
- Abdul-Rasheed OF, Al-Shamma GA, Zillo BH. Serum γ-glutamyltransferase as Oxidative Stress Markerin Pre-and Postmenopausal Iraqi Women. Oman Med J 2010;25:286-288.
- ACGIH Monograph. TLVs and BEIs, threshold limit values
- for chemical substances and physical agents and biological
- exposure indices. Cincinnati, OH: Signature Publications, 2011:122.
- Casale T, Rosati MV, Ciarrocca M, et al. Assessment of
- liver function in two groups of outdoor workers exposed to
- arsenic. Int Arch Occup Environ Health 2014;87:745-752.
- Kuo CC, Weaver V, Fadrowski JJ, et al. Arsenic exposure, hyperuricemia, and gout in US adults. Environ Int 2015;76:32-34.
- Robles-Osorio ML, Pérez-Maldonado IN, Martín del Campo D, et al. Urinary arsenic levels and risk of renal injury in a cross-sectional study in open population. Rev Invest Clin 2012;64:609-614.
- Mershiba SD, Dassprakash MV, Saraswathy SD. Protective
- effect of naringenin on hepatic and renal dysfunction and
- oxidative stress in arsenic intoxicated rats. Mol Biol Rep
- ;40:3681-3691.
- Yao ML, Zhang AH, Yu C, et al. The establishment of the
- arsenic poisoning rats model caused by corn flour baked
- by high-arsenic coal. Zhonghua Yu Fang Yi Xue Za Zhi
- ;47:799-805.
- Casale T, Rosati MV, Ciarrocca M, et al. Assessment of
- liver function in two groups of outdoor workers exposed to
- arsenic. Int Arch Occup Environ Health 2014;87:745-752.
- Lee DJ, Choi JS, Kim KM, et al. Combined effect of serum
- gamma-glutamyl transferase and uric acid on Framingham
- risk score. Arch Med Res 2014;45:337-342.
- Kim KM, Kim BT, Lee DJ, et al. Serum gamma-glutamyl transferase as a risk factor for general cardiovascular disease
- prediction in Koreans. J Investig Med 2012;60:1199-1203.
- Kong AP, Choi KC, Ho CS, et al. Associations of uric acid
- and gamma-glutamyltransferase (GGT) with obesity and
- components of metabolic syndrome in children and adolescents. Pediatr Obes 2013;8:351-357.
- Long Y, Zeng F, Shi J, et al. Gamma-glutamyltransferase
- predicts increased risk of mortality: a systematic review
- and meta-analysis of prospective observational studies.
- Free Radic Res 2014;48:716-728.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Araştırma Yazıları |
| Yazarlar | |
| Yayımlanma Tarihi | 8 Temmuz 2015 |
| Gönderilme Tarihi | 8 Temmuz 2015 |
| Yayımlandığı Sayı | Yıl 2015 Cilt: 42 Sayı: 2 |