Uses of curcumin in dentistry

Yıl 2021, Cilt: 3 Sayı: 3, 15 - 24, 31.10.2021

Burcu Güçyetmez Topal , Seher Gözde Uğur

Öz

Curcumin is the most important fraction responsible for turmeric's biological effects. Curcumin, with its wide biological activity, has an area of use in various treatments in the field of medicine and dentistry. Curcumin has been widely used in dentistry for restorative and endodontic procedures, jaw bone defects, periodontal problems, aphthous ulcers, precancerous lesions, mucositis. It has been found that curcumin has antibacterial properties against bacteria such as Streptococcus mutans, Lactobacillus casei and Actinomyces viscosus, which play a major role in dental caries.
It is very important that curcumin does not cause irritation in the pulpal tissue. Curcumin promotes cell viability and induces the proliferation of primary dental pulp fibroblasts by increasing Transforming growth factor beta production.
In addition, studies have shown that curcumin-containing mouthwashes can be used effectively in dentistry practices in addition to mechanical plaque control in preventing dental plaque and gingivitis. These properties have made curcumin interesting for dental procedures in milk and permanent teeth. The purpose of this review is to examine the usage areas of curcumin in the field of general dentistry, to compile studies in the literature and to update the information on this subject.

Anahtar Kelimeler

curcumin, turmeric, dentistry

Kurkuminin Dişhekimliğinde Kullanım Alanları

Öz

Kurkumin, zerdeçalın biyolojik etkilerinden sorumlu en önemli fraksiyondur. Kurkuminin, geniş biyolojik aktivitesiyle tıp ve diş hekimliği alanında çeşitli tedavilerde kullanım alanı bulunmaktadır. Kurkumin diş hekimliği alanında restoratif ve endodontik işlemler, çene kemiği defektleri, periodontal problemler, aftöz ülserler, prekanseröz lezyonlar, mukozitis gibi rahatsızlıklarda yaygın olarak kullanılmıştır. Diş çürüklerinde büyük rol oynayan Streptococcus mutans, Lactobacillus casei ve Actinomyces viscosus gibi bakterilere karşı kurkuminin antibakteriyel özellik gösterdiği bulunmuştur.
Kurkuminin pulpal dokuda irritasyona yol açmaması çok önemlidir. Kurkumin, hücre canlılığını teşvik eder ve Transforming growth factor beta üretimini artırarak primer dental pulpa fibroblastlarının çoğalmasını indükler.
Ayrıca yapılan araştırmalarda kurkumin içerikli gargaraların diş hekimliği uygulamalarında dental plak ve diş eti iltihabının önlenmesinde mekanik plak kontrolüne ek olarak etkili bir şekilde kullanılabileceğini göstermiştir. Bu özellikler kurkumini süt ve daimi dişlerdeki dental prosedürlerde ilgi çekici hale getirmiştir. Bu derlemenin amacı, kurkuminin genel diş hekimliği alanında kullanım alanlarının incelenip, literatürde yapılmış çalışmaların derlenmesi ve bu konudaki bilgilerin güncellenmesidir.

Anahtar Kelimeler

kurkumin,, zerdeçal, diş hekimliği

Kaynakça

• Referans1. Araújo NC, Fontana CR, Bagnato VS, Gerbi MEM. Photodynamic antimicrobial therapy of curcumin in biofilms and carious dentine. Lasers Med Sci. 2014;29(2):629–35.
• Referans2. Ramteke PW, John S. Turmeric: The Golden Spice of Life. Internatıonal J Pharmacautıcal Sci Res. 2012;3(7):1987–94.
• Referans3. Islam A, Rebello L, Chepyala S. Review on Nanoformulations of Curcumin (Curcuma longa Linn.): Special Emphasis on Nanocurcumin®. Int J Nat Life Sci. 2019;3(1):1–12.
• Referans4. Prabhakar A, Mandroli PS, Bhat K. Pulpotomy with curcumin: Histological comparison with mineral trioxide aggregate in rats. Indian J Dent Res. 2019;30(1):31–6. Referans5. Shome S, Talukdar A Das, Choudhury MD, Bhattacharya MK, Upadhyaya H. Curcumin as potential therapeutic natural product: a nanobiotechnological perspective. J Pharm Pharmacol. 2016;68(12):1481–500.
• Referans6. Chatterjee A, Debnath K, Rao NKH. A comparative evaluation of the efficacy of curcumin and chlorhexidine mouthrinses on clinical inflammatory parameters of gingivitis: A double-blinded randomized controlled clinical study. J Indian Soc Periodontol. 2017;21(2):132–7.
• Referans7. Song J, Choi B, Jin EJ, Yoon Y, Choi KH. Curcumin suppresses Streptococcus mutans adherence to human tooth surfaces and extracellular matrix proteins. Eur J Clin Microbiol Infect Dis. 2012 Jul;31(7):1347–52.
• Referans8. Periodontitis D, Alveoler Ç, Kaybı K, Direkt Ö, İndirekt V, Karşılaştırılması Y, et al. Comparison of Direct and Indirect Measurement Methods of Alveolar Bone Loss in Experimental Periodontitis Studies. Mehmet Akif Ersoy Üniversitesi Sağlık Bilim Enstitüsü Derg. 2016;4(1):11–20.
• Referans9. Adyanthaya A, Ismail S, Sreelakshmi N, Student P. Saudi Journal of Oral and Dental Research Indian traditional medicinal herbs against dental caries-an unsung past to a bright future. Int J Nat Life Sci. 2016;1(1):1–6.
• Referans10. Derviş E, Derviş E. Klinik Gelişim Oral Ülserler. Klin Gelişim. 2009;22(2):24–9.
• Referans11. Farid RM. A Focus on Curcumin Local Application in Oral Diseases Management: Mini Review. IOSR J Pharm. 2016;6(1):30–40.
• Referans12. Mandroli PS, Bhat K. An in-vitro evaluation of antibacterial activity of curcumin against common endodontic bacteria. J Appl Pharm Sci. 2013;3(10):106–8.
• Referans13. Hu P, Huang P, Chen WM. Curcumin inhibits the sortase a activity of the streptococcus mutans UA159. Appl Biochem Biotechnol. 2013;171(2):396–402.
• Referans14. Li X, Yin L, Ramage G, Li B, Tao Y, Zhi Q, et al. Assessing the impact of curcumin on dual-species biofilms formed by Streptococcus mutans and Candida albicans. Microbiologyopen. 2019;8(12):1–10.
• Referans15. Méndez D, Gutierres E, … ED-P and, 2018 U. Curcumin-mediated antimicrobial photodynamic therapy reduces the viability and vitality of infected dentin caries microcosms. Photodiagnosis Photodyn Ther. 2018;24:102–8.
• Referans16. Paschoal MA, Lin M, Santos-Pinto L, Duarte S. Photodynamic antimicrobial chemotherapy on Streptococcus mutans using curcumin and toluidine blue activated by a novel LED device. Lasers Med Sci. 2015;30(2):885–90.
• Referans17. Mandrol PS, Bhat K, Prabhakar AR. An in vitro evaluation of cytotoxicity of curcumin against human dental pulp fibroblasts. J Indian Soc Pedod Prev Dent. 2016;34(3):269–72.
• Referans18. Anuradha BR, Bai YD, Sailaja S, Sudhakar J, Priyanka M, Deepika V. Evaluation of Anti-Inflammatory Effects of Curcumin Gel as an Adjunct to Scaling and Root Planing: A Clinical Study. J Int oral Heal. 2015;7(7):90–3.
• Referans19. Akpinar A, Calisir M, Karakan NC, Alpan AL, Goze F, Poyraz O. Effects of curcumin on alveolar bone loss in experimental periodontitis in rats: A morphometric and histopathologic study. Int J Vitam Nutr Res. 2017;87(5–6):262–70.
• Referans20. Chaturvedi TP. Uses of turmeric in dentistry: An update. Indian J Dent Res. 2009;20(1):107.
• Referans21. Behal R, Mali AM, Gilda SS, Paradkar AR. Evaluation of local drug-delivery system containing 2% whole turmeric gel used as an adjunct to scaling and root planing in chronic periodontitis: A clinical and microbiological study. J Indian Soc Periodontol. 2011;15(1):35–8.
• Referans22. Varghese MK, D V N, Scariya L. Curcumin and Metronidazole in Periodontal Therapy. Int J Res Ayurveda Pharm. 2014;5(6):680–4.
• Referans23. Rai B, Kaur J, Jacobs R, Singh J. Possible action mechanism for curcumin in pre-cancerous lesions based on serum and salivary markers of oxidative stress. J Oral Sci. 2010;52(2):251–6.
• Referans24. Chainani-Wu N, Madden E, Lozada-Nur F, Silverman S. High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus. J Am Acad Dermatol. 2012;66(5):752–60.
• Referans25. Kuttan R, Sudheeran PC, Josph CD. Turmeric and curcumin as topical agents in cancer therapy. Tumori. 1987;73(1):29–31.
• Referans26. Patil K, Guledgud M V., Kulkarni PK, Keshari D, Tayal S. Use of curcumin mouthrinse in radio-chemotherapy induced oral mucositis patients: A pilot study. J Clin Diagnostic Res. 2015;9(8):ZC59–62.
• Referans27. Kılınç G. Derleme Çocuklarda Kemoterapi ve Radyoterapi İlişJournal of Medicinal Plants kili Oral Komplikasyonlar. Dokuz Eylül Üniversitesi Tıp Fakültesi Derg. 2012;26(1):75–83.
• Referans28. Saldanha SP, Almeida VD. A Comparative Study to Assess the Effectiveness of Turmeric Mouth Wash versus Saline Mouth Wash on Treatment Induced Oral Mucositis (Tiom) in a Selected Hospital at Mangalore. J Clin Res Bioeth. 2014;5(6):1.
• Referans29. Manifar S, Obwaller A, Gharehgozloo A, Kordi HRBS. Curcumin gel in the treatment of minor aphthous ulcer: A randomized, placebo- controlled trial. J Med Plants. 2012;11(41):40–5.
• Referans30. Antharjanm R SD, Balan Anita. Curcumin as a treatment modality in recurrent aphthous stomatitis. Kerala Dent J. 2009;32(4):206–8.