Aroclor 1254’e Maruz Kalan Elastinin Yapısında Meydana Gelen Değişikliklerin İncelenmesi

Yıl 2020, Cilt: 9 Sayı: 2, 137 - 146, 31.12.2020

Özlem Demirci , Pelin Uğurlu Nurcan Doğan , Ömer Acer , Ersin Kılınç

Öz

Elastin prolin, valin ve glisin aminoasitlerinin yoğun olarak yer aldığı hidrofobik bölge ve alanin aminoasitinin yer aldığı çapraz bağlanma bölgesinden oluşan ve omurgalı canlıların dokularına esneklik ve hareketlilik sağlayan bir protein çeşididir. Elastinde meydana gelecek hasarlar pek çok hastalığa neden olduğundan elastin proteini üzerine çok sayıda araştırma yapılmıştır. Fakat toksik bir maddeye maruz kalan elastinde oluşacak hasarla ilgili çalışmalar literatürde sınırlı sayıdadır. Bu amaçla önemli kalıcı organik kirleticilerden biri olan Aroclor 1254’e maruz kalan elastin proteininin yapısında meydana gelen değişiklikler histopatolojik olarak incelenmiş ve oluşan hasarın konsantrasyona bağlı olduğu tespit edilmiştir.

Anahtar Kelimeler

Aroclor 1254, Elastin, Histopatoloji

Destekleyen Kurum

Dicle Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü

Proje Numarası

FEN.17.025

Teşekkür

Makale, Dicle Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü tarafından desteklenen FEN.17.025 numaralı projeden üretilmiştir.

Investigation of Changes in the Structure of Elastin Exposed to Aroclor 1254

Öz

Elastin is a type of protein consisting of a hydrophobic region where proline, valine and glycine amino acids are densely located and a cross-linking region where alanine amino acids are located, and provide flexibility and mobility to the tissues of vertebrate organisms. Since the damage to the elastin causes many diseases, a lot of research has been done on elastin protein. However, studies on damage to elastin exposed to a toxic substance are limited in the literature. For this purpose, changes in the structure of the elastin protein exposed to Aroclor 1254, one of the important permanent organic pollutants, were examined histopathologically and it was determined that the damage occurred was concentration-dependent.

Anahtar Kelimeler

Aroclor 1254, Elastin, Histopathology

Proje Numarası

FEN.17.025

Kaynakça

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