Survivin Hakkında Bilinenler: Survivin İle İlgili Türkiye’de Yapılmış Olan Çalışmalar

Yıl 2015, Cilt: 5 Sayı: 3, 39 - 58, 25.06.2015

Recep Eröz , Duygu Bircan Hüseyin Yüce , Recep Özmerdivenli

Öz

İnsanlarda 3 intron ve 4 ekzondan meydana gelen Survivin geni kromozomun 17q25 bölgesinde yer alan 14,7 kb uzunluğunda olan ve 142 aminoasitlik, 16,5 KD ağırlığında proteini kodlayan bir gendir. Survivin; akciğer, böbrek, cilt, endometriyum, mide, kolon, meme, prostat, yumurtalık, lösemi, baş ve boyun kanseri gibi çeşitli kanser türlerinde aşırı ifade edilmesi, histopatolojisi ve promotör bölgesindeki polimorfizmler sebebiyle birçok kez araştırmacılar tarafından çalışılmış olan ve apoptoz inhibitör ailesinin üyesi olan bir gendir. Biz bu derlemede Survivin ile ilgili bilinenleri ve Türk popülasyonunda bugüne kadar Survivin ile yapılan çalışmaları Türkçe olarak okuyucuya sunmaya çalıştık. Böylece literatürdeki önemli bir eksiklik giderilebileceği gibi, araştırmacılara bundan sonra yapılacak olan çalışmalarda bu derlemenin yol göstereceği kanaatindeyiz.

Anahtar Kelimeler

Survivin; BIRC5 protein; polimorfizm; kanser; Türk populasyonu

Kaynakça

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