Antimicrobial and Antimutagenic Properties of Physalis alkekengi L.

Yıl 2024, Cilt: 10 Sayı: 1, 7 - 13, 30.06.2024

Selçuk Çeker , Hatice Öğütçü , Güleray Ağar , Meryem Şengül Köseoğlu

Öz

The application of herbal medicines is increasing day by day. Some bioactive compounds of medicinal plant have various therapeutic effects. In this study, the antimicrobial and antimutagenic of the Physalis alkekengi, used for various therapeutic effects were investigated. The methanol and water extracts of Physalis alkekengi L. were analyzed antimutagenic and antimicrobial activity. In the findings obtained, we determined that Physalis alkekengi L. has antimutagenic activity, especially at a concentration of 75 µL. In additional, antimicrobial activity of methanol and water extracts from of P. alkekengi fruits was examined against human pathogenic Gram positive and Gram-negative bacteria and yeasts. Methanol and water extracts of Physalis alkekengi L. showed varying degrees of inhibitor effects (15 mm-40 mm, 20mm-30 mm respectively) on the growth of the diverse pathogenic strains tested. Methanol extract of Physalis alkekengi L. showed higher activity than commercial antibiotics in S. epidermis, B. cereus, P. vulgaris and P. aeruginosa (30 mm, 40 mm, 25 mm, 30 mm, respectively). These findings indicated that the fruit extract of P. alkekengi L. has potential application as an ingredient in pharmaceuticals.

Anahtar Kelimeler

P. alkekengi L., Antimutagenic, SCE, Antimicrobial.

Kaynakça

• AFZAL J, ULLAH N, HUSSAIN Z AND RUKH S. 2017. Phytochemical analysis andantibacterial potential of leaf extract of bauhinia linn.: an ethnomedicinal plant.
• ALTUNDAS A, ERDOGAN Y, ÖGÜTCÜ H, KIZIL HE AND AGAR G. 2016. Synthesis and Invitro Antimicrobial and Anti-mutagenic Activities of some Novel 2-(2- Hydroxybenzylideneamino)-5, 7-dihydro-4Hthieno [2, 3-c] pyran-3-carbonitrile Derivatives. Fresenius Environ Bull 25: 54115418.
• ANKRAH NA, NYARKO AK, ADDO PG, OFOSUHENE M, DZOKOTO C, MARLEY E, ADDAE MM AND EKUBAN FA. 2003. Evaluation of efficacy and safety of a herbal medicine used for the treatment of malaria. Phytotherapy Research 17: 697-701.
• CEKER S, ORHAN F, SEZEN S, GULLUCE M, OZKAN H, ASLAN A AND AGAR G. 2018. Anti-mutagenic and anti-oxidant potencies of Cetraria aculeata (Schreb.) Fr., Cladonia chlorophaea (Flörke ex sommerf.) spreng. and Cetrelia olivetorum (Nyl.) WL Culb. & CF Culb. Iranian journal of pharmaceutical research: IJPR 17: 326.
• CHEN L-X, XIA G-Y, LIU Q-Y, XIE Y-Y AND QIU F. 2014. Chemical constituents from the calyces of Physalis alkekengi var. franchetii. Biochemical Systematics and Ecology 54: 3135.
• CHOI E-M AND HWANG J-K. 2003. Investigations of anti-inflammatory and antinociceptive activities of Piper cubeba, Physalis angulata and Rosa hybrida. Journal of Ethnopharmacology 89: 171-175.
• GE Y, DUAN Y, FANG G, ZHANG Y AND WANG S. 2009. Study on biological activities of Physalis alkekengi var. francheti polysaccharide. Journal of the Science of Food and Agriculture 89: 1593-1598.
• HANBERGER H, GARCIA-RODRIGUEZ J-A, GOBERNADO M, GOOSSENS H, NILSSON LE AND STRUELENS MJ. 1999. Antibiotic susceptibility among aerobic gram-negative bacilli in intensive care units in 5 European countries. Jama 281: 67-71.
• HELVACI S, KÖKDIL G, KAWAI M, DURAN N, DURAN G AND GÜVENÇ A. 2010. Antimicrobial activity of the extracts and physalin D from Physalis alkekengi and evaluation of antioxidant potential of physalin D. Pharmaceutical biology 48: 142-150.
• HONG J-M, KWON O-K, SHIN I-S, SONG H-H, SHIN N-R, JEON C-M, OH S-R, HAN S-B AND AHN K-S. 2015. Anti-inflammatory activities of Physalis alkekengi var. franchetii extract through the inhibition of MMP-9 and AP-1 activation. Immunobiology 220: 1-9.
• JACOBO-HERRERA NJ, BREMNER P, MÁRQUEZ N, GUPTA MP, GIBBONS S, MUNOZ E AND HEINRICH M. 2006. Physalins from Witheringia s olanacea as Modulators of the NF-κB Cascade. Journal of Natural Products 69: 328-331.
• JALALI H, NEJAD AM, EBADI A AND LAEY G. 2009. Ethnobotany and folk pharmaceutical properties of major trees or shrubs in northeast of Iran. Asian Journal of Chemistry 21: 5632.
• JANUÁRIO A, FILHO ER, PIETRO R, KASHIMA S, SATO D AND FRANÇA S. 2002. Antimycobacterial physalins from Physalis angulata L.(Solanaceae). Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives 16: 445-448.
• KHAN W, BAKHT J AND SHAFI M. 2016. Antimicrobial potentials of different solvent extracted samples from Physalis ixocarpa. Pakistan Journal of Pharmaceutical Sciences 29.
• KOÇOĞLU S, OGUTCU H AND HAYVALI Z. 2019. Photophysical and antimicrobial properties of new double-armed benzo-15crown-5 ligands and complexes. Research on Chemical Intermediates 45: 2403-2427.
• LI X, ZHANG C, WU D, TANG L, CAO X AND XIN Y. 2012. In vitro effects on intestinal bacterium of physalins from Physalis alkekengi var. Francheti. Fitoterapia 83: 14601465.
• LIU X, BIAN J, LI D, LIU C, XU S, ZHANG G, ZHANG L AND GAO P. 2019. Structural features, antioxidant and acetylcholinesterase inhibitory activities of polysaccharides from stem of Physalis alkekengi L. Industrial Crops and Products 129: 654-661.
• MEDINA-MEDRANO JR, ALMARAZ-ABARCA N, GONZÁLEZ-ELIZONDO MS, URIBESOTO JN, GONZÁLEZ-VALDEZ LS AND HERRERA-ARRIETA Y. 2015. Phenolic constituents and antioxidant properties of five wild species of Physalis (Solanaceae). Botanical studies 56: 1-13.
• NADAROGLU H, ALAYLI A, CEKER S, OGUTCU H AND AGAR G. 2020. Biosynthesis of Silver nanoparticles and investigation of genotoxic effects and antimicrobial activity. International Journal of Nano Dimension 11: 158-167.
• NAMJOYAN F, JAHANGIRI A, AZEMI ME, ARKIAN E AND MOUSAVI H. 2015. Inhibitory effects of Physalis alkekengi L., Alcea rosea L., Bunium persicum B. Fedtsch. and Marrubium vulgare L. on Mushroom Tyrosinase. Jundishapur journal of natural pharmaceutical products 10.
• NARTOP D, ÖZKAN EH, GÜNDEM M, ÇEKER S, AĞAR G, ÖĞÜTCÜ H AND SARı N. 2019. Synthesis, antimicrobial and antimutagenic effects of novel polymeric-Schiff bases including indol. Journal of Molecular Structure 1195: 877-882.
• NARTOP D, SARI N, ALTUNDAŞ A AND ÖĞÜTCÜ H. 2012. Synthesis, characterization, and antimicrobial properties of new polystyrene‐bound Schiff bases and their some complexes. Journal of Applied Polymer Science 125: 1796-1803.
• NASERI MKG, MOHAMMADIAN M AND PHARM Z. 2008. Antispasmodic effect of Physalis alkekengi fruit extract on rat uterus. Int J Reprod Biomed 6: 193-190.
• NITHYA C, GNANALAKSHMI B AND PANDIAN SK. 2011. Assessment and characterization of heavy metal resistance in Palk Bay sediment bacteria. Marine environmental research 71: 283-294.
• ÖĞÜTÇÜ H, YETIM NK, ÖZKAN EH, EREN O, KAYA G, SARI N AND DIŞLI A. 2017. Nanospheres caped Pt (II) and Pt (IV): synthesis and evaluation as antimicrobial and Antifungal Agent. Polish Journal of Chemical Technology 19: 74-80.
• PENG X, WU Q, GAO C, GAI C, YUAN D AND FU H. 2015. Chemical constituents from the fruit calyx of Physalis alkekengi var. francheti. Journal of Chinese Pharmaceutical Sciences 24: 600-606.
• PERRY P AND EVANS H. 1975. Cytological detection of mutagen–carcinogen exposure by sister chromatid exchange. Nature 258: 121.
• PINTO LA, MEIRA CS, VILLARREAL CF, VANNIER-SANTOS MA, DE SOUZA CV, RIBEIRO IM, TOMASSINI TC, GALVÃOCASTRO B, SOARES MB AND GRASSI MF. 2016. Physalin F, a seco-steroid from Physalis angulata L., has immunosuppressive activity in peripheral blood mononuclear cells from patients with HTLV1-associated myelopathy. Biomedicine & Pharmacotherapy 79: 129-134.
• PINTO NB, MORAIS TC, CARVALHO K, SILVA CR, ANDRADE GMD, BRITO GADC, VERAS ML, PESSOA ODL, RAO VS AND SANTOS FA. 2010. Topical antiinflammatory potential of Physalin E from Physalis angulata on experimental dermatitis in mice. Phytomedicine 17: 740-743.
• RUBAB S, BAHADUR S, HANIF U, DURRANI AI, SADIQA A, SHAFIQUE S, ZAFAR U, SHUAIB M, UROOJ Z AND NIZAMANI MM. 2021. Phytochemical and antimicrobial investigation of methanolic extract/fraction of Ocimum basilicum L. Biocatalysis and Agricultural Biotechnology 31: 101894.
• SARI N, ŞAHIN SÇ, ÖĞÜTCÜ H, DEDE Y, YALCIN S, ALTUNDAŞ A AND DOĞANAY K. 2013. Ni (II)-tetrahedral complexes: Characterization, antimicrobial properties, theoretical studies and a new family of charge-transfer transitions. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 106: 60-67.
• SHEKAR FOROSH S, CHANGIZI-ASHTIYANIS APB AND ATTARI M. 2012. The effect of Physalis alkekengi alcoholic extract on thyroid hormones concentrations in rats. Zahedan J Res Med Sci 13: 1-7.
• SHU Z, TANG Y, YANG Y, DING Z, ZHONG R, XIA T, LI X, ZHENG C, WEN Z AND LI W. 2021. Two new 3-hexenol glycosides from the calyces of Physalis alkekengi var. franchetii. Natural product research 35: 1274-1280.
• SHU Z, XING N, WANG Q, LI X, XU B, LI Z AND KUANG H. 2016. Antibacterial and antiinflammatory activities of Physalis alkekengi var. franchetii and its main constituents.Evidence-Based Complementary and Alternative Medicine 2016.
• SOARES MB, BELLINTANI MC, RIBEIRO IM, TOMASSINI TC AND DOS SANTOS RR. 2003. Inhibition of macrophage activation and lipopolysaccaride-induced death by secosteroids purified from Physalis angulata L. European journal of pharmacology 459: 107112.
• SOARES MBP, BRUSTOLIM D, SANTOS LA, BELLINTANI MC, PAIVA F, RIBEIRO YM, TOMASSINI TCB AND DOS SANTOS RR. 2006. Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection. International Immunopharmacology 6: 408-414.
• SUN J-L, JIANG Y-J AND CHENG L. 2021. Two new physalin derivatives from Physalis alkekengi L. var. franchetii (Mast.) Makino. Natural product research 35: 203-206.
• ŞAKIYANİ, ÖZDEMIR R AND ÖĞÜTCÜ H. 2014. Synthesis, characterization, and antimicrobial activities of new N-(2-hydroxy-1naphthalidene)-amino acid (L-Tyrosine, LArginine, and L-Lysine) Schiff bases and their manganese (III) complexes. Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 44: 417-423.
• WANG L, GU J, ZONG M, ZHANG Q, LI H, LI D, MOU X, LIU P, LIU Y AND QIU F. 2021. Anti-inflammatory action of physalin A by blocking the activation of NF-κB signaling pathway. Journal of Ethnopharmacology 267: 113490.
• XIANG Y, LIU X, MAO C, LIU X, CUI Z, YANG X, YEUNG KW, ZHENG Y AND WU S. 2018. Infection-prevention on Ti implants by controlled drug release from folic acid/ZnO quantum dots sealed titania nanotubes. Materials Science and Engineering: C 85: 214224.
• ZHANG C-Y, LUO J-G, LIU R-H, LIN R, YANG M-H AND KONG L-Y. 2016. 1H NMR spectroscopy-guided isolation of new sucrose esters from Physalis alkekengi var. franchetii and their antibacterial activity. Fitoterapia 114: 138-143.
• ZHU F, DAI C, FU Y, LOO JF, XIA D, GAO SP, MA Z AND CHEN Z. 2016. Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling. Oncotarget 7: 9462-9476.