PANDEMİNİN ERKEN DÖNEMİNDE COVID-19 İÇİN POTANSİYEL TEDAVİ SEÇENEKLERİ: HIZLI SİSTEMATİK İNCELEME

Yıl 2020, Cilt: 4 Sayı: 2, 36 - 48, 31.12.2020

Elife Dilmaç Artun , Banu Ayar , Gülcan Tecirli

Öz

SARS-CoV-2 enfeksiyonununa karşı pandeminin erken döneminde, hastalığı tedavi edebilecek etkinliği bilimsel olarak kanıtlanmış bir tedavi bulunmamakla birlikte, tanı alan hastaların sağlık durumlarının ciddiyetine göre her ülkede farklı tedaviler uygulamaktadırlar. Bu çalışmada, COVID-19 pandemisinin erken döneminde teda-vide kullanılabilecek potansiyel tedavi seçenekleri üzerine yapılan bilimsel çalışmalar ile ilgili hızlı bir gözden geçirme yapılması amaçlanmıştır. Literatür taraması, OVID-MEDLINE, Web of Science ve Dergipark veri tabanlarında 01.01.2020-25.04.2020 tarih aralığını kapsayacak şekilde yapılmıştır. Tarama sonucunda top-lam 629 çalışmaya ulaşılmış ve değerlendirme sonrasında kalan 25 çalışma tam metin değerlendirmesine tabi tutulmuştur. Sonuç olarak; COVID-19 pandemisinin erken döneminde, hastalığın tedavisine yönelik etkinliği henüz bilimsel olarak kanıtlanmış bir tedavinin bulunmadığı, ancak farklı ilaçların potansiyel etkileri ile ilgili güçlü kanıtlar elde edebilmek için klinik çalışmaların halen devam ettiği ve mevcut ilaç seçeneklerine de potan-siyel yan etkiler açısından dikkatli yaklaşılması gerektiğinin vurgulandığı görülmüştür. Tedavide kullanılabile-cek ilaçların etkilerine ilişkin tartışmaların geniş çaplı klinik araştırmalardan gelecek kanıtlarla cevaplanabile-ceği düşünülmektedir.

Anahtar Kelimeler

COVID_19, SARS-CoV-2, TEDAVİ, İLAÇLAR

Destekleyen Kurum

Sağlık Bakanlığı

POTENTIAL TREATMENT OPTIONS FOR COVID-19 IN THE EARLY STAGE OF THE PANDEMIC: A RAPID REVIEW

Öz

Although there is no proven effective treatment against SARS-CoV-2 infection in the early period of the pan-demic, countries apply different treatments according to the severity of health status of patients. In this study, it is aimed to conduct a rapid review of scientific studies on potential drug options that can be used in early treatment of the COVID-19 pandemic. The literature review has been conducted in OVID-Medline, Web of Sci-ence and Dergipark databases in between the dates 01.01.2020-25.04.2020. As a result of the review, a total of 629 study have been accessed and after the assesment being made 25 studies were subject to full text evalua-tion. In the study, as a result we have seen at the early stage of COVID-19 pandemic that there have been no drugs that the efficacy has been yet proved scientifictly. However, we have also seen that there are ongoing clinical trials in order to obtain strong evidence pertaining potential effects of the different kind of medicines and it has also been emphasized that there is a requirement to be cautious in terms of the potential side effects of current drugs. We believe the evidence obtained from the large-scale clinical trials will respond the ongo-ing debates for the effects of these medicines.

Anahtar Kelimeler

COVID-19, SARS-cOv-2, Treatment, Drugs

Kaynakça

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