Synthesis and characterization of new Piperazine-Dithiocarbamate compounds as potent MAO-A inhibitors

Yıl 2022, Cilt: 1 Sayı: 1, 1 - 7, 29.04.2022

Derya Osmaniye , Begüm Nurpelin Saglik , Serkan Levent , Yusuf Özkay , Zafer Asım Kaplancıklı

https://doi.org/10.55971/EJLS.1089254

Öz

Monoamine oxidase (MAO) enzymes have an important place in neurodegenerative diseases. While MAO-A inhibitors are used in depression; MAO-B enzyme has an important place in Parkinson's disease. Within the scope of this study, 7 new piperazine-dithiocarbamate derivative compounds were synthesized. Structure determinations of the compounds were performed using 1H-NMR, ¹³C-NMR and HRMS spectroscopic methods. The MAO inhibitory activities of the compounds were determined by in vitro fluorometric methods. According to the obtained results, compound 2d with IC₅₀=0.108±0.004 µM; compound 2e exhibited inhibitory activity with an IC₅₀=0.074±0.003 µM.

Anahtar Kelimeler

Dithiocarbamate, HRMS, Monoamine oxidase, NMR, Piperazine

Teşekkür

As the authors of this study, we thank Anadolu University Faculty of Pharmacy Central Laboratory for their support and contributions.

Kaynakça

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