Helicobacter pylori frequency and upper gastrointestinal system endoscopic findings in autoimmune hepatic diseases

Yıl 2016, Cilt: 24 Sayı: 3, 65 - 68, 02.01.2017

Elmas Kasap , Ufuk Demirci , Tahir Buran Hakan Yüceyar

https://doi.org/10.17940/endoskopi.466540

Öz

Background and Aims: Helicobacter pylori is the main cause of gastric lesions in chronic gastritis, autoimmune gastritis, peptic ulcer disease, and gastric cancer. Autoimmune liver disease is associated with various upper gastrointestinal mucosal lesions, which are not linked to the severity of the disease. The aim of this study was to retrospectively investigate upper gastrointestinal mucosal lesions in relation to the prevalence of Helicobacter pylori infection in autoimmune liver disease. Materials and Methods: This study included 99 patients with autoimmune liver disease and 110 dyspeptic patients as the control group. Endoscopy was performed in all patients, with biopsy specimens taken from the antrum and gastric body for histological examination and Helicobacter pylori detection. Patients were excluded if they had a history of acid suppression therapy, antibiotic or non-steroidal anti-inflammatory drug treatment, or if antrum and gastric body biopsy specimens could not be taken. Results: Helicobacter pylori was detected in 60% of autoimmune hepatitis cases, 57% of primary biliary cirrhosis cases, and 63% of controls. There was no statistically significant difference between the three groups. Abnormal findings during upper gastrointestinal endoscopy were found in 45% of autoimmune hepatitis cases, 52% primary biliary cirrhosis cases, and 43% of dyspeptic controls. Conclusion: Helicobacter pylori was detected in autoimmune liver disease cases at a similar frequency as in the control group. Endoscopic antral gastritis was more prevalent in autoimmune hepatitis than in primary biliary cirrhosis, but autoimmune liver disease was not significantly characterized by more upper gastrointestinal mucosal lesions than in dyspeptic controls.

Anahtar Kelimeler

Autoimmune liver disease, autoimmune hepatitis, primary biliary cirrhosis, Helicobacter pylori

Otoimmün karaciğer hastalıklarında Helicobacter pylori ve üst gastrointestinal endoskopi bulgularının sıklığı

Öz

Giriş ve Amaç: Helicobacter pylori birçok gastrik hastalığın nedenidir. Otoimmün karaciğer hastalıklarına diğer hastalıklar ile ilişkisiz olan çeşitli üst gastrointestinal sistem mukozal bulguları eşlik edebilir. Çalışmamızdaki amacımız retrospektif olarak otoimmun karaciğer hastalıklarında üst gastrointestinal endoskopi bulgularını taramak ve Helicobacter pylori ile ilişkisini araştırmaktır. Gereç ve Yöntem: Bu çalışmaya 99 otoimmün karaciğer hastası ve 110 kontrol grubu hastası dahil edilmiştir. Her hastanın antrumdan ve gastrik yüzeyden alınan endoskopik biyopsileri incelenmiş ve Helicobacter pylori varlığı değerlendirilmiştir. Hastalar daha öncesinde asit süpresyon, antibiyotik ya da steroid dışı inflamatuvar baskılayıcı ajan tedavisi almış ise ve veya çeşitli nedenler ile gastrik biyopsi alınmamış ise çalışmaya dahil edilmedi.Bulgular: Helicobacter pylori otoimmün hepatit hastalarında %60, primer biliyer siroz hastalarında %57 ve kontrol grubunda %63 saptandı. Üç grup arasında belirgin bir farklılık yoktu. Patolojik endoskopik bulgular otoimmün hepatit hastalarında %45, primer biliyer siroz hastalarında %52 ve kontrol grubunda %43 saptandı. Sonuç: Helicobacter pylori otoimmün hastalar ile kontrol grubu arasında benzer bulundu. Endoskopik antral gastrit otoimmün hepatit hastalarında yüksek saptansa da otoimmün karaciğer hastalarında dispeptik gruba göre belirgin bir endoskopik bulgu farklılığı saptanmadı.

Anahtar Kelimeler

Otoimmün karaciğer hastalığı, otoimmün hepatit, primer biliyer siroz, Helicobacter pylori, gastrik lezyon

Kaynakça

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