An Efficient Synthesis of Novel Type Chalcones Containing 8-hydroxyquinoline Under Green Conditions

Yıl 2018, Cilt: 11 Sayı: 2, 321 - 327, 31.08.2018

Tayfun Arslan

https://doi.org/10.18185/erzifbed.422796

Cited By: 2

Öz

In
this study, new type of chalcones containing
8-hydroxyquinoline as
an alternative to natural and synthetic chalcones have synthesized for the
first time using microwave irradiation with environmentally benign approach.
Firstly, (E)-1-(4-((8-hydroxyquinolin-5-yl)diazenyl)phenyl)ethanone (3) were synthesized by diazotization of
p-aminoacetophenone. Secondly, most important step of synthesis included the
Claisen-Schmidt condensation of chalcones using the microwave method. The
structures of all compounds were characterized by means of FT-IR, NMR and
elemental analysis.

Anahtar Kelimeler

Azo coupling, Chalcone, Diazotization, 8-Hydroxyquinoline

An Efficient Synthesis of Novel Type Chalcones Containing 8-hydroxyquinoline Under Green Conditions

Öz

Bu çalışmada, çevreci bir yaklaşımla mikrodalga ışıması kullanılarak
doğal ve sentetik kalkonlara alternatif olarak 8-hidroksikinolin içeren yeni
tip kalkonlar ilk kez sentezlendi. İlk olarak, (E)-1-(4-((8-hidroksikinolin-5-yl)diazenil)fenil)ethanon
(3) p-aminoasetofenonun
diazotizasyonu tarafından sentezlendi. İkincil olarak sentezin en önemli
adımını, mikrodalga yöntemi kullanılarak kalkonların Claisen-Schmidt kondenzasyonunu
içermektedir. Tüm bileşiklerin yapıları FT-IR, NMR ve elemental analiz
yöntemleriyle karakterize edildi.

Anahtar Kelimeler

Azo kenetlenme, Diazotizasyon, Kalkon, 8-Hidroksikinolin

Kaynakça

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