Synthesis and Antioxidant Activities of New 2-(4-methylphenylsulphonyl)-5-Aryl-1,3,4-Oxadiazole Compounds

Yıl 2021, Cilt: 14 Sayı: 1, 232 - 240, 31.03.2021

Nurhan Gümrükçüoğlu , Bahar Bilgin Sökmen

https://doi.org/10.18185/erzifbed.823431

Cited By: 2

Öz

Bu çalışmada, antioksidan aktiviteye sahip bazı yeni heterosiklik oksadiazol türevlerinin sentezlenmesi amaçlanmıştır. 1,3,4-oksadiazoller, 4-metilfenilsülfonilhidrazidin farklı aromatik asitlerle POCl3 varlığında kondenzasyon reaksiyonu sonucu elde edilmiştir. Sentezlenen bileşiklerin yapıları 1H NMR ve 13C NMR spektroskopisi kullanılarak desteklenmiş ayrıca ince tabaka kromotografisi kullanılarak saflıkları kontrol edilmiştir. Elementel analizleri Carlo Erba 1106 elementel analiz cihazında yapılmıştır. 2,5-disübstitüye-1,3,4-oksadiazol türevlerinin (1-5) antioksidan aktiviteleri, ABTS (2,2′-Azino-bis(3-etilbenzenotiyazolin-6-sülfonik asid), DPPH (1,1-difenil-2-pikrilhidrazil) radikal giderme aktiviteleri ve demir indirgeme gücü antioksidan kapasitesine göre incelenmiştir. Elde edilen sonuçlar, sentezlenen bileşiklerin (1-5) etkili antioksidan aktiviteye sahip olduğunu göstermiştir.

Anahtar Kelimeler

hydrazide, DPPH, ABTS, ferric reducing power

Yeni 2-(4-metilfenilsülfonil)-5-Aril-1,3,4-Oksadiazol Bileşiklerinin Sentezi ve Antioksidan Aktiviteleri

Öz

Bu çalışmada, antioksidan aktiviteye sahip bazı yeni heterosiklik oksadiazol türevlerinin sentezlenmesi amaçlanmıştır. 1,3,4-oksadiazoller, 4-metilfenilsülfonilhidrazidin farklı aromatik asitlerle POCl3 varlığında kondenzasyon reaksiyonu sonucu elde edilmiştir. Sentezlenen bileşiklerin yapıları 1H NMR ve 13C NMR spektroskopisi kullanılarak desteklenmiş ayrıca ince tabaka kromotografisi kullanılarak saflıkları kontrol edilmiştir. Elementel analizleri Carlo Erba 1106 elementel analiz cihazında yapılmıştır. 2,5-disübstitüye-1,3,4-oksadiazol türevlerinin (1-5) antioksidan aktiviteleri, ABTS (2,2′-Azino-bis(3-etilbenzenotiyazolin-6-sülfonik asid), DPPH (1,1-difenil-2-pikrilhidrazil) radikal giderme aktiviteleri ve demir indirgeme gücü antioksidan kapasitesine göre incelenmiştir. Elde edilen sonuçlar, sentezlenen bileşiklerin (1-5) etkili antioksidan aktiviteye sahip olduğunu göstermiştir.

Anahtar Kelimeler

hidrazid, DPPH, ABTS, demir indirgeme gücü

Kaynakça

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