Cytotoxic Activity Evaluation of Three New Metal Complexes

Yıl 2021, Cilt: 14 Sayı: 1, 306 - 313, 31.03.2021

Halime Güzin Aslan , Senem Akkoç , Zülbiye Kökbudak

https://doi.org/10.18185/erzifbed.875774

Öz

Salisilaldehit ve 1-amino-5-(4-metilbenzoil)-4-p-tolilpirimidin-2(1H)-on bir Schiff bazı olan 1-(2-hidroksibenzilidenamino)-5-(4-metilbenzoil)-4-p-tolilpirimidin-2 (1H)-on (S1) 'u hazırlamak için kullanıldı. Üç yeni kompleks (Ag (I), Pd (II) ve Pt (II)) bu şelat ligandından (S1) sentezlendi. Metal kompleksleri insan kolon kanser hücre hattına karşı tarandı ve gümüş kompleksinin, kullanılan standart ilaçtan daha fazla sitotoksik aktiviteye sahip olduğu bulundu.

Anahtar Kelimeler

Cytotoxic activity, Metal complexes, Schiff base

Destekleyen Kurum

Erciyes Üniversitesi

Proje Numarası

FBA-2013-4659

Teşekkür

The authors are grateful to Erciyes University’s Research Foundation (FBA-2013-4659) for financial support.

Yeni Metal Komplekslerinin Sentezi ve Sitotoksik Aktivite Değerlendirmesi

Öz

Salisilaldehit ve 1-amino-5-(4-metilbenzoil)-4-p-tolilpirimidin-2(1H)-on bir Schiff bazı olan 1-(2-hidroksibenzilidenamino)-5-(4-metilbenzoil)-4-p-tolilpirimidin-2(1H)-on (S1) 'u hazırlamak için kullanıldı. Üç yeni kompleks (Ag(I), Pd(II) ve Pt(II)) bu şelat ligantdan (S1) sentezlendi. Ag(I) kompleksi insan kolon kanser hücre hattına karşı tarandı ve gümüş kompleksinin kullanılan standart ilaçtan daha fazla sitotoksik aktiviteye sahip olduğu bulundu.

Anahtar Kelimeler

sitotoksik aktivite, kanser, metal kompleksleri, schiff bazı

Proje Numarası

FBA-2013-4659

Kaynakça

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