Vitamin D Effects on Folliculogenesis via Ovarian Paracrine Factors

Yıl 2022, Cilt: 3 Sayı: 3, 316 - 321, 30.11.2022

Damla Gül Fındık

https://doi.org/10.48176/esmj.2022.93

Öz

The folliculogenesis mechanism is a complex process involving various hormones, growth factors and signaling molecules. Future research on the mechanisms of follicular development will provide more comprehensive data on female reproductive life. Vitamin D affects folliculogenesis through steroidogenesis. Vitamin D receptor signaling in granulosa cells regulates hormone secretions through steroidogenic enzymes. Vitamin D and folliculogenesis associated mechanism is still not elucidated. Various ovarian-derived autocrineparacrine factors involved in different stages of folliculogenesis have been shown in studies. Vitamin D effects on folliculogenesis via these factors are significant to understanding the underlying mechanism. Inhibitors of dormant primordial follicle activation are Forkhead box O3a, anti-müllerian hormone, Phosphatase and tensin homolog and p27. Among these factors, Forkhead box O3a is an important molecule for primordial follicle activity regulation and apoptosis mechanisms in the ovary. The factors involved in the development of preantral follicle from the primary follicle are Transforming Growth Factor-β, Growth and differentiation factor 9, Bone morphogenetic protein 4,7,15 and activin. Growth and differentiation factor 9 and Bone morphogenetic protein 15 induce granulosa cell proliferation and preantral follicle development. This review aims to describe the association between Vitamin D and folliculogenesis through steroidogenesis and ovarian paracrine factors.

Anahtar Kelimeler

AMH, BMP15, FOXO, GDF9, steroidogenesis

Vitamin D’nin Ovaryan Parakrin Faktörler ile Follikülogenez Üzerindeki Etkisi

Öz

Follikülogenez mekanizması çeşitli hormonları, büyüme faktörlerini ve sinyal moleküllerini içeren karmaşık bir süreçtir. Foliküler gelişim mekanizmaları üzerine gelecekteki araştırmalar, dişi reprodüktif yaşamı hakkında daha kapsamlı veriler sağlayacaktır. Vitamin D, steroidogenez yoluyla follikülogenezi etkiler. Granüloza hücrelerinde Vitamin D reseptör sinyali hormon salgılarını steroidojenik enzimler aracılığıyla düzenler. Vitamin D ve follikülogenez ile ilişkili mekanizma hala aydınlatılamamıştır. Follikülogenezin farklı evrelerinde yer alan çeşitli over kaynaklı otokrin-parakrin faktörler çalışmalarda gösterilmiştir. Bu faktörler yoluyla follikülogenez üzerindeki Vitamin D etkileri, altta yatan mekanizmayı anlamak için önemlidir. Sessiz primordial follikül aktivasyonunun inhibitörleri, Forkhead box O3a, anti-müllerian hormon, Fosfataz ve tensin homologu ve p27’dir. Bu faktörler arasından Forkhead box O3a, overde primordial folikül aktivite regülasyonu ve apoptoz mekanizmaları için önemli bir moleküldür. Primer follikülden preantral follikülün gelişiminde rol oynayan faktörler, dönüştürücü büyüme faktörü-β, büyüme ve farklılaşma faktörü 9, kemik morfogenetik protein 4,7,15 ve aktivindir. Bu derleme, steroidogenez ve ovaryan parakrin faktörler aracılığıyla VitD ve follikülogenez arasındaki ilişkiyi açıklamayı amaçlamaktadır.

Anahtar Kelimeler

AMH, BMP15, FOXO, GDF9, steroidogenez

Kaynakça

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