Endometrial Polipi Ayırt Etmede İnflamatuar Belirteçlerin Rolü: Tek Merkez Sonuçları

Yıl 2024, Cilt: 6 Sayı: 4, 131 - 136, 06.11.2024

Büşra Şahin , Elif Yaman , Fatma Nur Düzenli , Fatih Davran

https://doi.org/10.46969/EZH.1538701

Öz

Amaç: Anormal uterin kanama nedeniyle endometrial örnekleme yapılan hastalarda endometrial polip varlığını öngörmede inflamatuar belirteçlerin rolünü değerlendirmek.
Yöntem: Mayıs 2023- Temmuz 2023 tarihleri arasında Akçakoca Devlet Hastanesine anormal uterin kanama ile başvuran ve endometriyal örnekleme yapılan hastaların patoloji sonuçları retrospektif olarak tarandı. Hastaların demografik özellikleri, Trombosit-lenfosit, nötrofil-lenfosit ve lenfosit-monosit oranları, sistemik immün inflamasyon indeksi hesaplandı. Hastalar patolojik tanıya göre endometrial polip ve diğer bening patolojiler olmak üzere gruplandırıldı. Malign ve premalign lezyonlar çalışmaya dahil edilmedi. Tetkik sonuçları ve inflamatuar belirteçler bu iki grup arasında karşılaştırıldı.
Bulgular: Çalışmaya 89 hasta dahil edildi. 38 hastanın patoloji sonucu endometrial polip iken 51 hastada diğer bening patolojiler saptandı. Endometrial polip olan hastalarda hemoglobin, hemotokrit, lenfosit, monosit, platelet, nötrofil ve PDW değişkenleri açısından anlamlı bir fark saptanmadı (p>0,05). PLR (trombosit-lenfosit oranı) ve SII (sistemik immün-inflamatuar indeks) endometial polip grubunda diğer bening patolojilere göre anlamlı olarak daha yüksek bulundu ( p<0,05). NLR (nötrofil-lenfosit oranı) endometrial polip grubunda daha yüksek olup anlamlı değildi (p: 0,056). SII endometrial polip grubunda 669884,4±410641,7 olup diğer bening patolojilere göre daha yüksekti (p<0,05).
Sonuç: Endometrial polip anormal uterin kanamanın önemli sebeplerinden biridir. NLR, PLR ve SII ek bir maliyet gerektirmeksizin kan testleri ile kolayca değerlendirilebilen sistemik immün yanıt parametreleridir. SII bening endometrial patolojiler arasında endometrial polipi ayırt etmede etkili ve basit bir tetkik olarak görünmektedir.

Anahtar Kelimeler

Anormal uterin kanama, Endometrial polip, sistemik immün-inflamatuar indeks

The Role of Inflammatory Markers in Distinguishing Endometrial Polyp: Single Center Results

Öz

Objective: To investigate the role of inflammatory markers in predicting the presence of endometrial polyps in patients undergoing endometrial sampling due to abnormal uterine bleeding.
Methods: The pathology results of patients who presented to Akçakoca State Hospital with abnormal uterine bleeding and underwent endometrial sampling between May 2023 and July 2023 were retrospectively examined. The demographic characteristics of the patients, platelet-lymphocyte, neutrophil-lymphocyte and lymphocyte-monocyte ratios and systemic immune inflammation index were calculated. Patients were categorized into endometrial polyps and other benign pathologies according to the pathological diagnosis. Malignant and premalignant lesions were not included in the study. The examination results and inflammatory markers were compared between these two groups.
Results: 89 patients were included in the study. While the pathological finding in 38 patients was an endometrial polyp, other benign pathologies were found in 51 patients. No significant difference was found in terms of hemoglobin, hematocrit, lymphocytes, monocytes, platelets, neutrophils and PDW variables in patients with endometrial polyps (p>0.05). PLR (platelet-to-lymphocyte ratio) and SII (systemic immune-inflammatory index) were significantly higher in the endometrial polyp group compared to other benign pathologies (p<0.05). NLR (neutrophil to lymphocyte ratio) was higher in the endometrial polyp group and was not significant (p: 0.056). SII was 669884.4±410641.7 in the endometrial polyp group and was higher than other benign pathologies. (p<0.05)
Conclusion: Endometrial polyps are one of the most important causes of abnormal uterine bleeding. NLR, PLR and SII are parameters of the systemic immune response that can be easily determined with blood tests at no additional cost. SII appears to be an effective and simple test to differentiate endometrial polyps from benign endometrial pathologies.

Anahtar Kelimeler

Abnormal uterine bleeding, Endometrial polyps, Systemic immune-inflammatory index

Kaynakça

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