Fluorene-9-Bisphenol and Its Effects on Living Beings

Yıl 2022, Cilt: 2 Sayı: 2, 76 - 86, 30.09.2022

Fatma Nur Akıncı , Aysel Çağlan Günal

Öz

Fluorene-9-Bisphenol (BHPF) is a substitute for Bisphenol A (BPA), one of the endocrine disruptors. BPA, on the other hand, is a harmful chemical substance that we can constantly encounter in our daily life. Its use is restricted due to its harmful effects on both the environment and living life. Therefore, in the production of plastic materials, alternatives have been shown as a building material. BHPF; which is used as a substitute, appears in food storage containers, toy materials, baby bottles and many other areas. Investigation of the effects that may occur as a result of exposure to this chemical compound, which has the potential to be endocrine disruptor, has only recently come to the fore. The creatures used in the researches are of the type that show the closest feature to the human organism and make their effects in aquatic life researchable. While preparing this review, studies revealing the neurological, cardiological, histological and endocrinological effects of BHPF on Danio rerio, Porcine(Pig), Chlorella vulgaris and CD-1 mouse model organisms were examined.

Anahtar Kelimeler

BHPF, Toxic Effects, Model Organisms

Fluorene-9-Bisphenol ve Canlılar Üzerindeki Etkileri

Öz

Fluorene-9-Bisphenol (BHPF), endokrin bozucu maddelerden biri olan Bisphenol A (BPA)' nın ikamesidir. BPA, günlük hayatta sürekli olarak karşılaşabileceğimiz zararlı bir kimyasal maddedir. Hem çevreye hem de canlı hayatına zararlı etkilerinden dolayı kullanımı kısıtlandırılmıştır. Bundan dolayı plastik malzemelerin üretilmesinde yapı maddesi olarak alternatiflere yönelim gösterilmiştir. Alternatif olarak kullanılan BHPF; gıda saklama kaplarında, oyuncak malzemelerinde, bebeklerin kullandığı biberonlarda ve daha birçok alanda karşımıza çıkmaktadır. Endokrin bozucu olma potansiyeline sahip bu kimyasal bileşiğe maruz kalınması sonucunda ortaya çıkabilecek etkilerinin araştırılması, daha yeni gündeme gelmiştir. Yapılan araştırmalarda kullanılan canlılar, insan organizmasına en yakın özelliği gösteren ve sucul hayatında etkilerini araştırılabilir kılan türdendir. Bu derleme hazırlanırken BHPF' nin Danio rerio, Porcine (Domuz), Chlorella vulgaris ve CD-1 fare model organizmaları üzerindeki nörolojik, kardiyolojik, histolojik ve endokrinolojik olarak etkilerinin neler olduğunu ortaya çıkaran araştırmalar incelenmiştir.

Anahtar Kelimeler

BHPF, Toksik Etkiler, Model Organizmalar

Kaynakça

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