GLİSEMİK İNDEKS VE GLİSEMİK YÜK KANSER GELİŞİMİNDE ETKİLİ MİDİR?

Yıl 2021, , 87 - 91, 09.04.2021

Taygun Dayı , Mustafa Hoca

https://doi.org/10.34108/eujhs.669377

Öz

Bu derleme yazıda glisemik indeks ve glisemik yükün kanser gelişimi üzerindeki potansiyel etkilerinin incelenmesi hedeflenmiştir. Glisemik indeks ve/veya glisemik yük değeri yüksek olan besinlerin; glukoz metabolizmasını etkileyerek ileri glikasyon son ürünlerinin oluşmasına, disbiyoz gelişmesine, insülin benzeri büyüme faktörü (insulin like growth factor, IGF) aracılığı ile hücre çoğalmasına ve Deoksiribo Nükleik Asit (DNA) hasarına neden olarak kanser gelişim riskini arttırıcı potansiyel etkiler gösterdiği mekanizmalar ile özetlenmiştir. Potansiyel olumsuz etkilerin en aza indirilmesi için glisemik içeriği düşük, posa içeriği yüksek olan karbonhidrat kaynaklarının tercih edilmesi önerilmektedir. Bu noktada uygun miktar ve sıklıkta sebze, meyve, tam tahıl, kurubaklagil ve yağlı tohum tüketimi önem arz etmektedir. Ek olarak bu önerileri karşılayabilmek adına Akdeniz diyeti optimal düzeyde benimsenmesi gereken bir beslenme modeli olarak önerilebilmektedir. 

Anahtar Kelimeler

Glisemik indeks, glisemik yük, kanser

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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DO GLYCEMIC INDEX AND GLYCEMIC LOAD EFFECT CANCER DEVELOPMENT?

Öz

The aim of this review article was examined the potential relationship between glycemic index, glycemic load and cancer. Glycemic index and/or glycemic load may affect glucose metabolism and cause the production of advanced glycation end products (AGE), dysbiosis development and insulin like growth factor (IGF) synthesis which may cause to cell proliferation and Deoxyribo Nnucleic Acid (DNA) damage and may increase risk of cancer. High dietary fiber intake is suggested to decrease these potential effects. Adequately consumptions of vegetables, fruits, whole grains, legumes and seeds have positive effects on these potential risk. For these beneficial effects, Mediterranean diet may be optimal dietary approach.

Anahtar Kelimeler

Glycemic index, glycemic load, cancer

Proje Numarası

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Kaynakça

• 1. Tyagi N, Sharma GN, Shrivastava B, Chaudhary N, Sahu N. Cancer: An overview. Int J Res Dev Pharm L Sci 2017; 6(5): 2740-7.
• 2. Shahab L, McGowan JA, Waller J, Smith SG. Prevalence of beliefs about actual and mythical causes of cancer and their association with socio-demographic and health-related characteristics: Findings from a cross-sectional survey in England. EJC 2018; 103(1): 308-16.
• 3. Patel A, Pathak Y, Patel J, Sutariya V. Role of nutritional factors in pathogenesis of cancer. FQS 2018; 2(1): 27-36.
• 4. Sieri S, Agnoli C, Pala V, et al. Dietary glycemic index, glycemic load and cancer risk: Results from the EPIC-Italy study. Sci Rep 2017; 7(1): 1-7.
• 5. Sarkar S, Horn G, Moulton K, et al. Cancer development, progression and therapy: An epigenetic overview. Int J Mol Sci 2013; 14(10): 21087-1113.
• 6. World Health Organization.org [Internet]. [20.10.19]. https://www.who.int/news-room/fact-sheets/detail/cancer.
• 7. Tandon M, Siddique RA, Arvind, et al. Anti-cancer diet: Reviewing the role of nutrition in cancer prevention. Curr Top Nutraceut R 2008; 6(2): 67-82.
• 8. Vidal AC, Williams CD, Allott EH, et al. Carbohydrate intake, glycemic index and prostate cancer risk. Prostate 2015; 75(4): 430-9.
• 9. Eleazu CO. The concept of low glycemic index and glycemic load foods as panacea for type 2 diabetes mellitus; prospects, challenges and solutions. Afr Health Sci 2016; 16(2): 468-79.
• 10. AlGeffari MA, Almogbel ES, Alhomaidan HT, El-Mergawi R, Barrimah IA. Glycemic indices, glycemic load and glycemic response for seventeen varieties of dates grown in Saudi Arabia. Ann Saudi Med 2016; 36(6): 397-403.
• 11. Manisha, Hasan W, Rajak R, Jat D. Oxidative stress and antioxidants: An overview. IJARR 2017; 2(9): 110-9.
• 12. Saha SK, Lee SB, Won J, et al. Correlation between oxidative stres, nutrition and cancer initiation. Int J Mol Sci 2017; 18(7): 1-30.
• 13. Calaf GM, Urzua U, Termini L, Aguayo F. Oxidative stress in female cancers. Oncotarget 2018; 9(34): 23824-42.
• 14. Ahmed OM. Relationships between oxidative stress, cancer development and therapeutic interventions. J Can Sci Res 2016; 1(1): 1-2.
• 15. Giordano S, Darley-Usmar V, Zhang J. Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease. Redox Biol 2014; 2(1): 82-90.
• 16. Gross LS, Li L, Ford ES, Liu S. Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: An ecologic assessment. Am J Clin Nutr 2004; 79(5): 774-9.
• 17. Rossino MG, Casini G. Nutraceuticals for the treatment of diabetic retinopathy. Nutrients 2019; 11(4): 1-29.
• 18. Tan LB, Norhaizan ME, L W. Nutrients and oxidative stress: Friend or foe? Oxid Med Cell Longev 2018; 1(1): 1-24.
• 19. Tomasello G, Mazzola M, Leone A, et al. Nutrition, oxidative stress and intestinal dysbiosis: Influence of diet on gut microbiota in inflammatory bowel diseases. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2016; 160(4): 461-6.
• 20. Toor D, Wasson MK, Kumar P, et al. Dysbiosis disrupts gut immune homeostasis and promotes gastric diseases. Int J Mol Sci 2019; 20(10): 1-14.
• 21. Mills S, Stanton C, Lane JA, Smith GJ, Ross RP. Precision nutrition and the microbiome, part I: Current state of the science. Nutrients 2019; 11(4): 1-45.
• 22. Dumitrescu L, Popescu-Olaru I, Cozma L, et al. Oxidative stress and the microbiota-gut-brain axis. Oxid Med Cell Longev 2018; 1(1): 1-12.
• 23. Vivarelli S, Salemi R, Candido S, et al. Gut microbiota and cancer: From pathogenesis to therapy. Cancers 2019; 11(1): 1-26.
• 24. Simpson A, Petnga W, Macaulay VM, Weyer-Czernilofsky U, Bogenrieder T. Insulin-like growth factor (IGF) pathway targeting in cancer: Role of IGF axis and oppurtunities for future combination studies. Targ Oncol 2017; 12(5): 571-97.
• 25. Clemmons DR. Metabolic actions ıf IGF-I in normal physiology and diabetes. Endocrinol Metab Clin North Am 2012; 41(2): 425-43.
• 26. Hu Y, Block G, Norkus EP, et al. Relations of glycemic index and glycemic load with plasma oxidative srtess markers. Am J Clin Nutr 2006; 84(1): 70-6.
• 27. Huang J, Fang Y, Xu M, et al. Carbohydrate, dietary glycaemic index and glycaemic load and colorectal cancer risk: A case-control study in China. Brit J Nutr 2018; 119(8): 937-48.
• 28. Anderson C, Milne GI, Park YM, Sandler DP, Nichols HB. Dietary glycemic index and glycemic load are positively associated with oxidative stress among premenopausal women. J Nutr 2018; 148(1): 125-30.
• 29. Gnagnarella P, Gandini S, Vecchia CL, Maisonneuve P. Glycemic index, glycemic load and cancer risk: A meta-analysis. Am J Clin Nutr 2008; 87(6): 1793-801.