PERİODONTAL HASTALIK, ATEROSKLEROZ VE OKSİDATİF STRES İLİŞKİSİ: DERLEME

Yıl 2020, Cilt: 29 Sayı: 1, 56 - 65, 04.05.2020

Ayşegül Sarı , Kamile Erciyas , İbrahim Levent Taner

https://doi.org/10.34108/eujhs.563506

Öz

Peridontal hastalıklar
dişin destek dokularında enflasyonla ve yıkımla karakterize enfeksiyöz
hastalıklardır. Periodontal hastalığın ilerlemesinde, bakteriyel kolonizasyona
karşı gelişen immünolojik reaksiyonlar önemli rol oynamaktadır. Periodontal
hastalıklar ile kardiovasküler hastalıkların temel etkeni olan ateroskleroz
arasındaki direk nedensel ilişki tam olarak belirlenememesine karşın, her iki
hastalığı ilişkilendiren farklı patolojik mekanizmalar ve ortak risk faktörleri
mevcuttur. Aterosklerotik plakların periodontal patojenlerle enfeksiyonu,
periodontal enflamasyonun kronik sistemik enflamasyon yoluyla aterojenik etki
oluşturması her iki hastalığın olası ilişkisini açıklayan olası mekanizmalardandır.
Serbest radikaller ile koruyucu antioksidan sistem arasındaki dengenin
bozulması sonucu meydana gelen oksidatif stresin, son yıllarda her iki
hastalığın başlaması ve ilerlemesiyle ilişkili enflamatuar bir belirteç olduğu
üzerinde durulmaktadır. Bu derlemede periodontal hastalık, ateroskleroz ve
oksidatif stres arasındaki ilişkinin ele alınması amaçlanmıştır.

Anahtar Kelimeler

Periodontal hastalık, ateroskleroz, oksidatif stres

Kaynakça

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