Therapeutic plasmapheresis: an eleven-year clinical experience

Year 2018, Volume: 4 Issue: 4, 343 - 348, 04.10.2018

Yasemin Tekdöş Şeker , Gülsüm Oya Hergünsel Deniz Özel Bilgi

https://doi.org/10.18621/eurj.356552

Abstract

Objective: Therapeutic plasma exchange (TPE) is currently
indicated as an alternative treatment regimen in a number of guidelines for
various medical conditions. In this article we retrospectively reviewed cases
who underwent TPE in Bakırköy Dr. Sadi Konuk Training and Research Hospital
intensive care unit between 2007 and 2016 and compared the findings to the
current reports in the literature.

Methods: A total of 80 cases were
treated with TPE between 2007 and 2016 in our intensive care unit. Information
on demographic variables, therapeutic indications, catheterized veins,
complications during the procedure, number of sessions, replacement products
used and survival data was collected. In addition, pre- and post-procedure
serum triglyceride, cholesterol and amylase levels were also collected in acute
pancreatitis cases associated with hypertriglyceridemia.

Results: A total of 501
TPE sessions were performed on 80 cases comprising 35 neurology, 18 hematology,
12 hypertriglycemic acute pancreatitis and 7 acute hepatic insufficiency
patients, along with 8 cases with less common indications including sepsis,
hyperthyroidism resistant to medical therapy and toxic epidermal necrolysis.
The age of the subjects ranged between 12 and 82 years (mean; 45.08 ± 14.67
years). Sixteen (23.19%) cases died before the completion of the planned
sessions. Pre- and post-procedure serum triglyceride, cholesterol and amylase
levels were significantly different in acute pancreatitis cases (p < 0.05).

Conclusion: Timely
implementation of TPE in applicable indications may be helpful in preventing
morbidity and mortality in a wide spectrum of disorders. 

Keywords

plasmapheresis, plasma exchange, pancreatitis, Guillain barre syndrome, intensive care unit

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