Is there a difference in 25-hydroxyvitamin D levels between female university students with and without joint hypermobility?

Year 2019, Volume: 5 Issue: 4, 576 - 581, 04.07.2019

Filiz Tuna , Hande Özdemir Derya Demirbağ Kabayel , Zeynep Banu Doğanlar

https://doi.org/10.18621/eurj.411056

Cited By: 1

Abstract

Objectives:
Individuals with joint hypermobility (JH) constitute a sensitive group with
regard to musculoskeletal problems. This study aimed to investigate whether
females with generalized joint hypermobility (GJH) are at risk of
hypovitaminosis D compared with non-GJH female participants and whether there
is a relationship between vitamin D levels, Beighton score and musculoskeletal
complaints.

Methods: In this
cross-sectional, descriptive and case-control study, 76 female participants aged
18-25 years were included. The Beighton score with a cut-off of 4/9 was applied
for defining GJH. In addition, serum biochemical (the enzymatic colorimetric
method) and hormonal (the electrochemiluminescence method) parameters were
evaluated.

Results: The mean
serum 25-hydroxyvitamin D (25[OH]D) levels of GJH (n = 38) and non-GJH (n = 38)
groups were 15.70 ± 7.96 ng/mL and 16.80 ± 5.45 ng/mL, respectively. There was
no statistically significant difference between the groups in terms of
biochemical and hormonal parameters. We found vitamin D deficiency in 89.5% of
participants with GJH, and 84.2% of controls. There was no correlation between
vitamin D, Brighton criteria, and musculoskeletal complaints.

Conclusion: The
female participants with GJH showed similar frequency of musculoskeletal
complaints and similar low level of 25(OH)D in relation to controls. 

Keywords

female, joint hypermobility, musculoskeletal complaints, 25-hydroxyvitamin D deficiency

References

• [1] Beighton P, De Paepe A, Steinmann B, Tsipouras P, Wenstrup RJ. Ehlers-Danlos syndromes: revised nosology. Villefranche, 1997. Ehlers-Danlos National Foundation (USA) and Ehlers-Danlos Support Group (UK). Am J Med Genet 1988;77:31-7.
• [2] Castori M, Tinkle B, Levy H, Grahame R, Malfait F, Hakim A. A framework for the classification of joint hypermobility and related conditions. Am J Med Genet C Semin Med Genet C Semin Med Genet 2017;175:148-57.
• [3] Malfait F, Francomano C, Byers P, Belmont J, Berglund B, Black J, et al. The 2017 international classification of the Ehlers-Danlos syndromes. Am J Med Genet 2017;175:8-26.
• [4] Wintermeyer E, Ihle C, Ehnert S, Stöckle U, Ochs G, de Zwart P, et al. Crucial role of vitamin D in the musculoskeletal system. Nutrients 2016;8. pii:E319.
• [5] Rombaut L, Scheper M, De Wandele I, De Vries J, Meeus M, Malfait F, et al. Chronic pain in patients with the hypermobility type of Ehlers–Danlos syndrome: evidence for generalized hyperalgesia. Clin Rheumatol 2015;34:1121-9.
• [6] Eller-Vainicher C, Bassotti A, Imeraj A, Cairoli E, Ulivieri FM, Cortini F, et al. Bone involvement in adult patients affected with Ehlers-Danlos syndrome. Osteoporosis Int 2016;27:2525-31.
• [7] Gulbahar S, Sahin E, Baydar M, Bircan C, Kizil R, Manisali M, et al. Hypermobility syndrome increases the risk for low bone mass. Clin Rheumatol 2006;25:511-4.
• [8] Scheper MC, de Vries JE, de Vos R, Verbunt J, Nollet F, Engelbert RH. Generalized joint hypermobility in professional dancers: a sign of talent or vulnerability? Rheumatology 2013;52:651-8.
• [9] Kumar B, Lenert P. Joint hypermobility syndrome: recognizing a commonly overlooked cause of chronic pain. Am J Med 2017;130:640-7.
• [10] Engelbert RH, Juul-Kristensen B, Pacey V, de Wandele I, Smeenk S, Woinarosky N, et al. The evidence‐based rationale for physical therapy treatment of children, adolescents, and adults diagnosed with joint hypermobility syndrome/hypermobile Ehlers Danlos syndrome. Am J Med Genet C Semin Med Genet 2017;175:158-67.
• [11] Joghee S, Dewan V, Chhabra A, Jahan A, Sharma N, Yadav TP. Vitamin D levels in children with idiopathic musculoskeletal pain. Int J Basic Appl Sci 2014;3:21-7.
• [12] Juul-Kristensen B, Røgind H, Jensen DV, Remvig L. Inter-examiner reproducibility of tests and criteria for generalized joint hypermobility and benign joint hypermobility syndrome. Rheumatology (Oxford) 2007;46:1835-41.
• [13] Kasapoğlu Aksoy M, Altan L, Ökmen Metin B. The relationship between balance and vitamin 25(OH)D in fibromyalgia patients. Mod Rheumatol 2017;27:868-74.
• [14] [cited 2018 20/03/2018]; Available from: https://mgm.gov.tr/veridegerlendirme/il-ve-ilceler-istatistik.aspx?m=EDIRNE.
• [15] Beighton P, Solomon L, Soskolne C. Articular mobility in an African population. Ann Rheum Dis 1973;32:413-8.
• [16] Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96:1911-30.
• [17] Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega-Janneh M, Reynolds J, et al. The relationship between obesity and serum 1, 25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 2004;89:1196-9.
• [18] Karahan AY, Hüner B, Kuran B, Sezer N, Çelik C, Salbaş E, et al. [Assessment of the relationship between vitamin D level and non-specific musculoskeletal system pain: a multicenter retrospective study (Stroke Study Group)]. Turk J Osteoporos 2017;23:61-6. [Article in Turkish]
• [19] Holick M, Hossein-Nezhad A, Tabatabaei F. Multiple fractures in infants who have Ehlers-Danlos/hypermobility syndrome and or vitamin D deficiency: a case series of 72 infants whose parents were accused of child abuse and neglect. Dermatoendocrinol 2017;9:e1279768.
• [20] Busch A, Hoffjan S, Bergmann F, Hartung B, Jung H, Hanel D, et al. Vascular type Ehlers-Danlos syndrome is associated with platelet dysfunction and low vitamin D serum concentration. Orphanet J Rare Dis 2016;11:111.