Viruslar ve Teratogenez

Yıl 2017, , 115 - 122, 15.12.2017

Cüneyt Tamer , Semra Okur Gümüşova

https://doi.org/10.35864/evmd.523469

Cited By: 1

Öz

Hayvancılıkta reprodüksiyon sorunları işletmelerin mücadele edeceği önemli sorunlardan birisi olarak kabul edilir ve erken teşhisi edilmesi önem taşır. Teratojen ajanlar ise, gebelik döneminde gelişimsel bozukluklara neden olarak reprodüktif sorunlar oluşturan önemli etkenlerdendir. Enfeksiyöz teratojen ajanlar içerisinde sınıflandırılan viral etkenler de reprodüktif sorunların önemli nedenlerinden birisi olarak kabul edilir. Teratojen virusların birçoğu gebelik döneminde asemptomatik seyreder ve latentlik periyodu nedeniyle teşhisi zordur. Bu durum virusların saçılmasını kolaylaştırdığından sürü sağlığını tehdit etmektedir. Bu derleme ile önemli viral teratojenler hakkında yapılmış çalışmaların verileri toparlanıp özetlenerek bu konudaki bilgilerin güncellenmesi amaçlanmıştır.

Anahtar Kelimeler

Patogenez, teratogenez, virus

Kaynakça

• 1. Agerholm JS, Hewicker-Trautwein M, Peperkamp K, Windsor PA, (2015) Virus-induced congenital malformations in cattle. Acta Vet Scand. 57: 54. 2. Bahr C, Kuiper H, Distl O, (2003) Bilateral anophthalmia associated with further anomalies of the head in German Holstein calves. Dtsch Tierarztl Wochenschr. 110 (11): 454- 456. 3. Bayrou C, Garigliany MM, Sarlet M, Sartelet A, Cassart D, Desmecht D, (2014) Natural intrauterine infection with Schmallenberg virus in malformed newborn calves. Emerg Infect Dis. 20: 1327-1330. 4. Deleu L, Pujol A, Faisst S, Rommelaere J, (1999) Activation of promoter P4 of the autonomous parvovirus minute virus of mice at early S phase is required for productive infection. J Virol. 73:3877–3885. 5. Garigliany M, Gilliaux G, Jolly S, Casanova T, Bayrou C, Gommeren K, Fett T, Mauroy A, Lévy E, Cassart D, Peeters D, Poncelet L, Desmecht D, (2016) Feline panleukopenia virus in cerebral neurons of young and adult cats. BMC Vet Res. 12(1):28. 6. Herder V, Hansmann F, Wohlsein P, Peters M, Varela M, Palmarini M, Baumgartner W, (2013) Immunophenotyping of inflammatory cells associated with Schmallenberg virus infection of the central nervous system of ruminants. PLoS One. 8(5):1-11. 7. Hoffmann B, Scheuch M, Hoper D, Jungblut R, Holsteg M, Schirrmeier H, Eschbaumer M, Goller KV, Wernike K, Fischer M, Breithaupt A, Mettenleiter TC, Beer M, (2011) Novel orthobunyavirus in Cattle, Europe. Emerg Infect Dis. 18(3):469–479. 8. International Committee on Taxonomy of Viruses. (2012). http://www.ictvonline.org/taxonomyHistory.asp?taxnode_ id=20142920&taxa_name=Parvoviridae Erişim tarihi: 03.04.2016. 9. Jenckel M, Bréard E, Schulz C, Sailleau C, Viarouge C, Hoffmann B, Höper D, Beer M, Zientara S, (2015) Complete coding genome sequence of putative novel bluetongue virus serotype 27. Genome Announc. 3(2):1-2. 10. Karakaya E, Alpay G, Yilmazbas-Mecitoglu G, Alasonyalilar-Demirer A, Akgül B, Inan-Ozturkoglu S, Ozyigit MO, Seyrek-Intas D, Seyrek-Intas K, Yesilbag K, Gumen A, Keskin A, (2013) Perosomus elumbis in a Holstein calf infected with bovine viral diarrhea virus. Tierarztl Prax Ausg G Grosstiere Nutztiere. 41(6):387-391. 11. MacLachlan NJ, Conley AJ, Kennedy PC, (2000) Bluetongue and equine viralarteritis viruses as models of virus-induced fetal injury and abortion. Anim Reprod Sci. 60-61: 643-651. 12. MacLachlan NJ, Dubovi EJ, (2011) Fenner’s Veterinary Virology. 4. Baskı, Kalifornia. Elsevier. 62-380 13. Maxie MG, (2015) Kennedy & Palmer’s Pathology of Domestic Animals, 6. Baskı, Ontario, 3:283-432. 14. OIE, Bunyaviral Diseases of Animals. http://www.oie.int/ fileadmin/Home/fr/Health_ standards/tahm /2.09.01_bunyaviral_ diseases.pdf Erişim Tarihi: 07.05.2016 15. Oura CA, E Harrak M, (2011) Midge-transmitted bluetongue in domestic dogs. Epidemiol Infect. 139 (9): 1396- 1400. 16. Parrish CR, (1995) Pathogenesis of feline panleukopenia virus and canine parvovirus. Baillieres Clin Haematol. 8:57-71. 17. Peperkamp NH, Luttikholt SJ, Dijkman R, Vos JH, Junker K, Greijdanus S, Roumen MP, van Garderen E, Meertens N, van Maanen C, Lievaart K, van Wuyckhuise L, Wouda W, (2015) Ovine and Bovine Congenital Abnormalities Associated With Intrauterine Infection With Schmallenberg Virus. Vet Pathol. 52(6):1057-1066. 18. Peters M, Mösenfechtel S, Jacobsen B, Beineke A, Wohlsein P, (2008) Bluetongue virus serotype 8 (BTV- 8)-associated brain malformations in two calves. Dtsch Tierarztl Wochenschr. 115(8):298-303. 19 Schelp C, Greiser-Wilke I, (2003) BVD diagnosis: an overview. Berl Munch Tierarztl Wochenschr. 116:227-233. 20. Vandevelde M, Higgins RJ, Oevermann A, (2012) Veterinary Neuropathology. 1. Baskı, Oxford. 92-94. 21. Williamson SM, Scholes SF, Welchman D. de B, Dennison M, Batten CA, Williams DL, Mertens PPC, Mellor PS, (2010) Bluetongue virus serotype 8-associated hydranencephaly in two calves in south-eastern England. Vet Rec. 167:216-218. 22. Wouda W, Peperkamp NH, Roumen MP, Muskens J, van Rijn A, Vellema P, (2010) Epizootic congenital hydranencephaly and abortion in cattle due to bluetongue virus serotype 8 in the Netherlands. Tijdschr Diergeneeskd. 134:422–427.