Development and Characterization of Nanofiber Strip Containing Sertraline for Buccal Application

Yıl 2023, Cilt: 48 Sayı: 3, 385 - 394, 18.10.2023

Kutsal Özcan , Sibel İlbasmış Tamer , Eylül Su Saral Acarca

https://doi.org/10.55262/fabadeczacilik.1313014

Öz

Sertraline is one of the selective serotonin reuptake inhibitors indicated in major depressive disorder. Schizophrenia is a mental disorder with frequent depressive symptoms. Sertraline is thought to be useful for the treatment of depressive symptoms in schizophrenia. The objective of this study is to formulate sertraline-containing nanofiber strips produced by the electrospinning process, which can be easily dispersed by the buccal route, suitable for the use of schizophrenia patients. Here, various ratios (%5, %7.5 and %10) of polyvinyl pyrrolidone (PVP) polymer solutions were prepared, and electrical conductivity, viscosity and surface tension characterization studies were performed on polymer solutions. After characterization studies, a polymer solution containing 5% PVP was selected to prepare nanofibers. Nanofibers were obtained by using the electrospinning method, each strip containing 5 mg sertraline. It was observed that the optimum formulation selected nanofiber had an average particle diameter of 371-439 nm in the SEM image. Tensile strength and elongation at break percentage values of 5% PVP-sertraline nanofibers values were 0.449±0.284 (Mpa) and 22.6±3.66 (%), respectively. The loading capacity and encapsulation efficiency of the formulation are 4.53%±0.31 and 79.61±10.56 respectively. In vitro drug dissolution studies showed that sertraline-containing buccal nanofibers conformed to the Hixson-Crowell kinetic model.

Anahtar Kelimeler

Nanofiber, electrospinning, sertraline, polyvinyl pyrrolidone (PVP), buccal strip

Kaynakça

• Al-Nimry, S. S., & Jaber, M. A. (2017). Preparation and optimization of sertraline hydrochloride tablets with improved dissolution through crystal modification. AAPS PharmSciTech, 18, 1190-1202. https://doi.org//10.1208/s12249-016-0586-z.
• Amariei, N., Manea, L. R., Bertea, A. P., Bertea, A., & Popa, A. (2017). The influence of polymer solution on the properties of electrospun 3D nanostructures. Mater Sci Eng, 209(1), 012092. https://doi. org//10.1088/1757-899X/209/1/012092.