Cyclic Imides Derivatives: A Potential Scaffold For The Synthesis Of Anticonvulsant Agents

Yıl 2024, Cilt: 49 Sayı: 2, 401 - 422, 25.08.2024

Shweta Singh , Amita Rana , Mahendra Rana Hraday Kant Awasthi Amrita Verma Pargaien Himanshu Joshi

https://doi.org/10.55262/fabadeczacilik.1451555

Öz

Cyclic non-aromatic nitrogen heterocycles such as phthalimides, maleimides, and succinimides are an intriguing class of compounds with an immense range of biological activities such as anti-convulsant, anti-inflammatory, anti-microbial, analgesic, and hypolipidemic activities, as well as numerous pharmaceutical uses. Phthalimide, maleimide, and succinimide have an imide functional group and can be considered nitrogen analogs of anhydrides. The imide ring and general structure of CO-N(R)-CO found in cyclic imides, including phthalimides, maleimides, succinimides, and their derivatives, impart hydrophobicity and neutral properties onto the respective derivatives. The unsubstituted cyclic imide is a crucial feature that has been shown to retain considerable biological activity. In this article, we intend to investigate several phthalimides, maleimides, and succinimide derivatives, their chemistry, structural activity relationship (SAR), and anticonvulsant activity, considering their immense biological activities.

Anahtar Kelimeler

Heterocyclic compounds, Imide ring, Phthalimides, Maleimides, Succinimides, Structural activity relationship, Anticonvulsant activity

Etik Beyan

N.A

Destekleyen Kurum

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Proje Numarası

N.A

Kaynakça

• Kamiński, K., Rapacz, A., Filipek, B., & Obniska, J. (2016). Design, synthesis and anticonvulsant activity of new hybrid compounds derived from N-phenyl-2-(2, 5-dioxopyrrolidin-1-yl)- propanamides and-butanamides. Bioorganic & Medicinal Chemistry, 24(13), 2938-2946.