The effect of radiotherapy on neurogenic speech and language disorders of patients with primary brain tumour in the early period

Yıl 2023, Cilt: 4 Sayı: 1, 32 - 36, 30.04.2023

Bertuğ Sakın , Gökhan Yaprak , Beyhan Ceylaner Bıçakçı , Fatih Demircioğlu , Serhat Aras , Merve Sapmaz Atalar , Beyza Pehlivan

https://doi.org/10.51753/flsrt.1209373

Öz

Within the scope of the study, it is aimed to reveal the effect of radiotherapy applied to neurogenic speech and language disorder patients diagnosed with primary brain tumour in the early period. The participants of the study consist of 35 patients selected among those with primary brain tumour who applied to the Radiation Oncology Unit of İstanbul Kartal Dr. Lütfi Kırdar Training and Research Hospital. Within the scope of the research, Gülhane Aphasia Test 2 (GAT-2) and Standardized Mini Mental Test (MMT) were applied to the participants before they received radiotherapy. GAT-2 and MMT were reapplied to the patients 30 days after they had received radiotherapy as part of the treatment process. Results of the study indicated that, before radiotherapy, tumours formed in the frontal and temporal lobes, including the dominant language centers, had a negative effect on the cognitive performance of the patients, as well as their speech and language skills. However, after radiotherapy was applied, two patients with tumours in the left parietal lobe had a decrease in their speech and language skills, while no deterioration was observed in the speech and language skills of the other participants. This may be due to the early phase of radiotherapy.

Anahtar Kelimeler

Brain tumour, neurolinguistics, radiotherapy, speech and language disorders

Kaynakça

• Allison, K. M., Cordella, C., Iuzzini-Seigel, J., & Green, J. R. (2020). Differential diagnosis of apraxia of speech in children and adults: a scoping review. Journal of Speech Language and Hearing Research, 63(9), 2952-2994.
• ASHA, (2023). American Speech Language and Hearing Association, https://www.asha.org/. Last accessed on April 12, 2023.
• Ardila, A. (2014). Aphasia handbook. Miami, Florida International University.
• Ceccaldi, M., Joanette, Y., Tikhomirof, F., Macia, M., & Poncet, M. (1996). The effects of age-induced changes in communicative abilities on the type of aphasia. Brain and Language, 54(1), 75-85.
• Cho, K. H., Kim, J. Y., Lee, S. H., Yoo, H., Shin, S. H., Moon, S. H., ... & Pyo, H. R. (2010). Simultaneous integrated boost intensity-modulated radiotherapy in patients with high-grade gliomas. International Journal of Radiation Oncology Biology Physics, 78(2), 390-397.
• Davis, G. A. (2007). Aphasiology: Disorders and clinical practice. Pearson College Division.
• Dickey, L., Kagan, A., Lindsay, M. P., Fang, J., Rowland, A., & Black, S. (2010). Incidence and profile of inpatient stroke-induced aphasia in Ontario, Canada. Archives of Physical Medicine and Rehabilitation, 91(2), 196-202.
• Duffy, J. R. (2006). Apraxia of speech in degenerative neurologic disease. Aphasiology, 20(6), 511-527.
• Duffy, J. R. (2013). Motor speech disorders e-book: Substrates, differential diagnosis, and management. Rochester, Minnesota, Elsevier Health Sciences.
• Duffy, J. R., Utianski, R. L., & Josephs, K. A. (2020). Primary progressive apraxia of speech: From recognition to diagnosis and care. Aphasiology, 35(4), 560-591.
• Fischer, R. S., Alexander, M. P., Gabriel, C., Gould, E., & Milione, J. (1991). Reversed lateralization of cognitive functions in right handers. Exceptions to classical aphasiology. Brain: A Journal of Neurology, 114 (Pt 1A), 245-261.
• Freed, D. B. (2011). Motor speech disorders: diagnosis and treatment. Plural Publishing.
• Goodglass, H., & Kaplan, E. (1972). The assessment of aphasia and related disorders. Philadelphia, Lea & Febiger.
• Hallowell, B. (2017). Aphasia and other acquired neurogenic language disorders. San Diego, Plural Publushing.
• Hegde, M. N., & Freed, D. (2016). Assessment of communication disorders in adults: Resources and protocols. San Diego, Plural Publishing.
• Helm-Estabrooks, N., Albert, M. L., & Nicholas, M. (2004). Manual of aphasia and aphasia therapy. PRO-ED. Inc., Austine, Texas.
• Hess, C. F., Schaaf, J. C., Kortmann, R. D., Schabet, M., & Bamberg, M. (1994). Malignant glioma: patterns of failure following individually tailored limited volume irradiation. Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology, 30(2), 146-149.
• Hund-Georgiadis, M., Zysset, S., Weih, K., Guthke, T., & von Cramon, D. Y. (2001). Crossed nonaphasia in a dextral with left hemispheric lesions: a functional magnetic resonance imaging study of mirrored brain organization. Stroke, 32(11), 2703-2707.
• Kang, E. K., Sohn, H. M., Han, M. K., & Paik, N. J. (2017). Subcortical aphasia after stroke. Annals of Rehabilitation Medicine, 41(5), 725-733.
• McNeil, M. R., Robin, D. A., & Schmidt, R. A. (2009). Apraxia of speech: Definition and differential diagnosis. Clinical Management of Sensorimotor Speech Disorders, 2, 249-267.
• Mega, M. S., & Alexander, M. P. (1994). Subcortical aphasia: the core profile of capsulostriatal infarction. Neurology, 44(10), 1824-1829.
• Mesulam, M. M. (2001). Primary progressive aphasia. Annals of Neurology, 49(4), 425-432.
• Michaud, D., Schiff, D., & Batchelor, T. (2017). Incidence of primary brain tumors. https://www.uptodate.com/. Last accessed on April 12, 2023.
• NAA, (2023). National Aphasia Association. Aphasia FAQs. https://www.aphasia.org/aphasia-faqs/. Last accessed on April 12, 2023.
• Noone, A. M., Howlader, N., Krapcho, M., Miller, D., Brest, A., Yu, M., ... & Cronin, K. A. (2015). SEER Cancer Statistics Review, 1975-2015. National Cancer Institute.
• Ozduman, K., Hacihanefioglu, M., & Pamir, M. N. (2019). Glioblastom. Türk Nöroşirürji Dergisi, 29(3), 305-334.
• Pedersen, P. M., Jørgensen, H. S., Nakayama, H., Raaschou, H. O., & Olsen, T. S. (1995). Aphasia in acute stroke: incidence, determinants, and recovery. Annals of Neurology, 38(4), 659-666.
• Rampello, L., Rampello, L., Patti, F., & Zappia, M. (2016). When the word doesn’t come out: A synthetic overview of dysarthria. Journal of the Neurological Sciences, 369, 354-360.
• Roseberry-McKibbin, C., & Hegde, M. N. (2006). An advanced review of speech-language pathology: preparation for PRAXIS and comprehensive examination. PRO-ED, Inc. 8700 Shoal Creek Blvd, Austin, TX 78757.
• Roth, F. P., & Worthington, C. K. (2015). Treatment resource manual for speech-language pathology. San Diego, Plural Publishing.
• Savci, A. B. (2006). Kanserli hastalarda yaşam kalitesini ve sosyal destek düzeyini etkileyen faktörler, Yüksek Lisans Tezi, (pp. 1-95). Atatürk University Institute of Health Sciences, Faculty of Medicine, Department of Public Health, Erzurum.
• Spreen, O., & Risser, A. H. (2003). Assessment of aphasia. (pp. 1-319). Oxford University Press, New York.
• Stupp, R., Mason, W. P., Van Den Bent, M. J., Weller, M., Fisher, B., Taphoorn, M. J., ... & Mirimanoff, R. O. (2005). Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. New England Journal of Medicine, 352(10), 987-996.
• Walker, M. D., Alexander, E., Hunt, W. E., MacCarty, C. S., Mahaley, M. S., Mealey, J., ... & Strike, T. A. (1978). Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. Journal of Neurosurgery, 49(3), 333-343.