Phytochemical screening and radical scavenging activity of green coffee bean extract: Multiple-protective efficacy against Bisphenol A

Yıl 2021, Cilt: 10 Sayı: 3, 256 - 275, 31.12.2021

Burhan Durhan Emine Yalçın , Kültigin Çavuşoğlu , Ali Acar

Öz

In this study, phytochemical characterization, radical scavenging activity and the protective role of green coffee bean extract (Gcbe) against Bisphenol-A (BpA) were evaluated. In phytochemical analysis total phenolic, flavonoid and tannin contents were investigated and major components were determined by HPLC. The amerolative effect of Gcbe against BpA-induced toxicity were studied in albino mice. For this purpose, mice were separated into six groups which treated with tap-water, BpA and two doses of Gcbe. To determine BpA toxicity and the protective role of Gcbe, changes in some biochemical parameters, micronucleus (MN) frequency and DNA fragmentation were investigated. As a result, the phenolic compounds in the Gcbe content were more intense than the other components. In BpA-treated group, serum parameters increased and the antioxidant/oxidant dynamics were impaired. Gcbe treatment decreased the induced serum parameters and caused an improvement in antioxidant-oxidant dynamics and also a decrease in the DNA-tail percentage and MN frequency.

Bisphenol A, Comet, Green coffee bean extract, Phytochemical characterization, Radical scavenging activity

Anahtar Kelimeler

Bisphenol A, Comet, Grren Coffee bean extract, phytochemical characterization, radical scavenging activity

Proje Numarası

Giresun Üniversitesi Araştırma Fonu- FEN-BAP-C-200515-18

Phytochemical screening and radical scavenging activity of green coffee bean extract: Multiple-protective efficacy against Bisphenol A

Öz

In this study, phytochemical characterization, radical scavenging activity and the protective role of green coffee bean extract (Gcbe) against Bisphenol-A (BpA) were evaluated. In phytochemical analysis total phenolic, flavonoid and tannin contents were investigated and major components were determined by HPLC. The amerolative effect of Gcbe against BpA-induced toxicity were studied in albino mice. For this purpose, mice were separated into six groups which treated with tap-water, BpA and two doses of Gcbe. To determine BpA toxicity and the protective role of Gcbe, changes in some biochemical parameters, micronucleus (MN) frequency and DNA fragmentation were investigated. As a result, the phenolic compounds in the Gcbe content were more intense than the other components. In BpA-treated group, serum parameters increased and the antioxidant/oxidant dynamics were impaired. Gcbe treatment decreased the induced serum parameters and caused an improvement in antioxidant-oxidant dynamics and also a decrease in the DNA-tail percentage and MN frequency.

Anahtar Kelimeler

Bisphenol A, Comet, Green coffee bean extract, phytochemical characterization, radical scavenging activity

Destekleyen Kurum

Giresun Üniversitesi-BAP

Proje Numarası

Giresun Üniversitesi Araştırma Fonu- FEN-BAP-C-200515-18

Kaynakça

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