Akut ve Subakut Derin Ven Trombozu Hastalarında Tiroid Disfonksiyonu Birlikteliği

Yıl 2022, Cilt: 32 Sayı: 2, 177 - 181, 29.04.2022

Elif Coşkun Sungur , Levent Altınay , Mustafa Buyukates , Erol Aktunç

https://doi.org/10.54005/geneltip.1036264

Öz

Amaç: Tiroid disfonksiyonu olan hastalarda koagülasyon bozuklukları, subklinik laboratuvar anormalliklerinden hayatı tehdit eden kanamalara veya trombotik olaylara kadar uzanır. Çalışmamızda, akut-subakut DVT tespit edilen hastalarda, trombofili sebebi olarak tiroid disfonksiyonu araştırılması amaçlanmıştır.

Gereç ve Yöntem: Kasım 2015 ile Haziran 2016 arasında DVT tanısı almış 30 hasta bu vaka kontrol çalışmasına dahil edilmiştir. Hastalar provoke (bilinen etiyolojisi olan, n = 13) ve provoke edilmemiş (bilinmeyen etiyolojisi olan n = 17) hastalar olarak iki gruba ayrıldı. Provoke hasta grubu edinsel risk faktörleri (yatkınlık) ve / veya genetik risk faktörleri olan hastalar olarak ayrıldı.

Bulgular: Proveke grup ve Unprovake gruplar arasında tiroit disfonksiyonu sıklığı arasında istatistiksel olarak anlamlı fark bulunamamıştır (p=0.844). DVT geçiren hastalarımızın %70’inde PAI-1 gen mutasyonuna rastlanırken, Protrombin gen mutasyonu hastaların hiçbirinde tespit edilememiştir. Provake eden faktörler arasında en sık erkek cinsiyet ve 3 ay içinde majör cerrahi geçirmiş olma bulunmuştur.

Sonuç: Çalışmamızda akut-subakut DVT teşhis edilen hastalar ile tiroit disfonksiyonu birlikteliği arasında net bir ilişki bulunamamıştır. Bu nedenle 'provokatif faktörlerin' tiroid disfonksiyonu ile venöz tromboembolizm (VTE) ilişkisini destekleyebileceğini düşünüyoruz.Bu konuda prospektif ve daha geniş kohortlu çalışmaların yapılması gerektiğini düşünüyoruz.

Anahtar Kelimeler

derin ven trombozu, tiroid disfonksiyonu, trombofili

Thyroid dysfunction coexistence in patients with acute and subacute deep vein thrombosis

Öz

Objective: Coagulation anomalies in patients with thyroid dysfunction may vary from subclinical disorders in laboratory tests to life threatening thrombotic events or bleeding. We aimed to determine the effect of thyroid dysfunction on thrombophilia in patients with acute and subacute deep vein thrombosis (DVT).

Materials and Methods: A number of 30 patients with the diagnosis of DVT between November 2015 and June 2016 included in this case - control study. The patients divided into two groups as provoked (with known ethiology, n = 13) and unprovoked (with un-known ethiology, n = 17) patients. Provoked patients group divided as the patients with acquired risk factors (predisposition) and/or the patients with genetic risk factors.

Results: The difference of the rate of the thyroid dysfunction between the provoked and unprovoked groups was not significant (p=0.844). The PAI – 1 gene mutation was detected in 70% of the study cohort and none of the patients had prothrombin gene mutation. The most provocative factors for DVT were male gender and undergoing a major surgery in the last three months.

Conclusions: There was no correlation between acute – subacute DVT and thyroid dysfunction in this study. Therefore, we think that the ‘provocative factors’ may support the relation of thyroid dysfunction and venous thromboembolism (VTE). We think that more studies with larger cohorts and prospective should be conducted about this subject.

Anahtar Kelimeler

deep vein thrombosis, thyroid dysfunction, thrombophilia

Kaynakça

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