Skeletal Muscle Mass, Muscle Strength, and Quality of Life in Adult Patients with Familial Mediterranean Fever: A Comparative Study with Healthy Controls

Yıl 2023, Cilt: 33 Sayı: 5, 536 - 540, 25.10.2023

İsa Cüce , Rıdvan Yıldızhan , Sinem Kübra Konca , Hasan Kara , Enes Veziroğlu , Taha Furkan Çakır , Melih Kızıltepe , Emel Oğuz Kökoğlu , Abdurrahman Soner Şenel

https://doi.org/10.54005/geneltip.1306834

Öz

Aim: This study (1) compared skeletal muscle mass (SMM) and muscle strength in familial Mediterranean fever (FMF) patients with those of healthy controls (HCs) and (2) investigated the association of SMM and muscle strength with disease severity and quality of life (QOL).
Materials and Methods: This study included 31 FMF patients and 30 matched HCs. Disease severity was evaluated using the International Severity Scoring System for FMF (ISSF). Body composition parameters were measured using a bioelectrical impedance analysis. Grip and pinch strengths were calculated for muscle strength. Health status was assessed with Short Form 36 (SF-36).
Results: The all-body composition parameters of the FMF patients, including SMM, were similar to those of the HCs, with significantly lower grip and pinch strengths. All SF-36 scores of the FMF patients were significantly lower than those of the HCs. Positive correlations were observed between muscle-related indices and pinch strength for some SF-36 domains.
Conclusion: Muscle- or fat-related indices were similar among adult patients with FMF and the HCs. In contrast, patients with FMF had a poorer health-related QOL and lower grip and pinch strengths than the HCs. Further studies are needed to determine the clinical significance of these correlations in patients with FMF.

Anahtar Kelimeler

Familial Mediterranean fever, skeletal muscle, muscle strength, quality of life

Erişkin Ailevi Akdeniz Ateşi Hastalarında İskelet Kası Kütlesi, Kas Kuvveti ve Yaşam Kalitesi: Sağlıklı Kontrollerle Karşılaştırmalı Bir Çalışma

Öz

Amaç: Bu çalışmanın amacı, (1) erişkin ailevi Akdeniz ateşi (AAA) hastalarında iskelet kası kütlesi (İKK) ve kas kuvvetini sağlıklı kontrollerle (SK) karşılaştırmak ve (2) İKK ve kas kuvveti ile hastalık şiddeti ve yaşam kalitesi arasındaki ilişkiyi araştırmaktı.
Gereç ve Yöntemler: Çalışmaya 31 AAA hastası ve eşleştirilmiş 30 SK dâhil edildi. Hastalık şiddeti, AAA için uluslararası şiddet skorlama sistemi (ISSF) kullanılarak değerlendirildi. Vücut kompozisyon parametreleri, biyoelektrik impedans analizi (BİA) kullanılarak ölçüldü. Kas kuvveti için el kavrama ve parmak kavrama kuvvetleri değerlendirildi. Yaşam kalitesi, Kısa Form-36 (KF-36) kullanılarak değerlendirildi.
Bulgular: AAA hastalarının İKK dâhil tüm vücut kompozisyon parametreleri SK gruba ile benzer, el kavrama ve parmak kavrama kuvvetleri ise istatistiksel olarak anlamlı düşüktü. AAA hastalarının tüm KF-36 skorları SK grubundan anlamlı düşüktü. Kasla ilgili indeksler ve parmak kavrama kuvveti ile bazı KF-36 skorları arasında pozitif korelasyonlar bulundu.
Sonuç: Bu çalışma, erişkin AAA hastalarında BİA ile ölçülen kas veya yağ ile ilişkili indekslerin SK grubu ile benzer olduğunu göstermiştir. Buna karşılık, AAA hastalarında sağlıkla ilgili yaşam kalitesi ve el kavrama ve parmak kavrama kuvvetleri SK grubundan daha düşüktü. FMF hastalarında bu korelasyonların klinik önemini belirlemek için ise daha ileri çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

Ailevi Akdeniz Ateşi, iskelet kası, kas kuvveti, yaşam kalitesi

Kaynakça

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