Hpv-Specific Risk Management in Cervical Pathology Screening and Comparison of Pathological Results

Yıl 2023, Cilt: 33 Sayı: 6, 775 - 778, 31.12.2023

Sıtkı Özbilgeç , Şeyma Çiçek , Tuğçehan Şimşekler , Fatih Akkuş , Emine Türen Demir , Ali Acar

https://doi.org/10.54005/geneltip.1340317

Öz

Background: In the process of detecting cervical cancer, cytology and HPV genotype screening both play a significant part. More researches are required to determine whether or not multiple HPV genotyping can accurately predict cytological abnormalities.
Methods: A total of 696 female individuals were subjected to analysis for cytology and HPV genotype testing. HPV-DNA, smear and final pathology results of these patients and the relationship between them were investigated using statistical methods.
Results: Cytological data indicating abnormalities were seen in a total of 110 subjects. HPV-16 was determined to be the most prevalent variety among the patients, and HPV-16-positive females were found to have an elevated risk of cervical lesions. HPV 16 infection rates were substantially increased in patients with HSIL and higher lesions.
Conclusion: An infection caused by HPV-16 is a major risk factor for cervical lesions. A test that examines many HPV genotypes may be able to predict cytological problems.

Anahtar Kelimeler

HPV, Smear, Cervical Screening, Cervical Preinvasive Lesions, Cervical Cancer

Servikal Patoloji Taramasında Hpv’ye Özgü Risk Yönetimi ve Patoloji Sonuçlarının Karşılaştırılması

Öz

Arka plan: Serviks kanserinin saptanması sürecinde sitoloji ve HPV genotip taramasının her ikisi de önemli bir rol oynamaktadır. Çoklu HPV genotiplemesinin sitolojik anormallikleri doğru bir şekilde tahmin edip edemeyeceğini belirlemek için daha fazla araştırma yapılması gerekmektedir.
Yöntemler: Toplam 696 kadın birey sitoloji ve HPV genotip testi için analize tabi tutulmuştur. Bu hastaların HPV-DNA, smear ve nihai patoloji sonuçları ve aralarındaki ilişki istatistiksel yöntemler kullanılarak araştırılmıştır.
Bulgular: Toplam 110 olguda anormallik gösteren sitolojik veriler görüldü. HPV-16’nın hastalar arasında en yaygın çeşit olduğu ve HPV-16-pozitif kadınlarda servikal lezyon riskinin yüksek olduğu bulunmuştur. HPV 16 enfeksiyon oranları HSIL ve daha yüksek lezyonlu hastalarda önemli ölçüde artmıştır.
Sonuç: HPV-16’nın neden olduğu bir enfeksiyon servikal lezyonlar için önemli bir risk faktörüdür. Birçok HPV genotipine bakan bir test sitolojik sorunları öngörebilir.

Anahtar Kelimeler

HPV, Smear, Servikal Tarama, Servikal Preinaziv Lezyonlar, Serviks Kanseri

Kaynakça

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