Düzeltme:
Another Face of the Post-COVID Syndrome in Elderly Patients: Increased Frailty Due to Systemic Inflammation
Yıl 2024,
Cilt: 7 Sayı: 2, 169 - 169, 31.08.2024
Gülbahar Darılmaz Yüce
,
Funda Salgür
,
Samra Kamilova
,
Özgün Çiçek
,
Matin Iskandarov
,
Meriç Yavuz Çolak
,
Gaye Ulubay
,
M. Şule Akçay
Düzeltme Notu
In the article titled "Another Face of the Post-COVID Syndrome in Elderly Patients: Increased Frailty Due to Systemic Inflammation" published in the Journal of Geriatric Science (Year: 2023, Volume: 6, Issue: 2), the ethics committee approval date was incorrectly stated as 30 March 2020. The correct date is 30 March 2022. The authors sincerely apologize for this oversight. This correction aims to amend the error in the original article.
Öz
Aim: COVID-19 is known to be a condition that creates long-term morbidity and mortality in older adults. There is not enough information yet about the relationship between COVID-19 and frailty. In our study, we investigated whether COVID-19 increases frailty, a condition that can be counted among its long-term effects.
Materials and Methods: The study included 73 patients over the age of 65 who were hospitalized in the Başkent University Medical Faculty Hospital COVID-19 Isolation Service, with positive COVID-19 PCR test. Patients were categorized as mild-moderate, severe, and critical pneumonia requiring intensive care unit admission. The FRAIL Frailty scale was applied to the patients on the first day of hospitalization. The FRAIL Frailty scale was applied again at the 3rd month follow-up after discharge. FRAIL index were compared on the first day of hospitalization and 3 months after discharge due to COVID-19.
Results: 58.9% of the patients participating in our study were male and 41.1% were female. Their mean age was 77.48±7.68 years. The mean FRAIL score was 1.34±0.12 on the first day of hospitalization and 2.24±0.12 after discharge. The mean change in FRAIL score between the first day of hospitalization and after discharge was 60.3% and was statistically significant (p<0.001). The change was the highest in the intensive care unit group, with 95% (p<0.001).
Conclusion: COVID-19 increases systemic inflammation, leading to increased frailty. Elderly patients should be evaluated for frailty during and after COVID-19.
Kaynakça
- Marengoni A, Zucchelli A, Vetrano DL, et al. Beyond Chronological Age: Frailty and Multimorbidity Predict In-Hospital Mortality in Patients With Coronavirus Disease 2019. J Gerontol A Biol Sci Med Sci. 2021;76(3):38-15.
- Fulop T, Witkowski JM, Olivieri F, et al. The integration of inflammaging in age-related diseases. Semin. Immunol. 2018; 40:17–35.
- PS, Madhavan S, Pandurangan V. Prevalence, Pattern and Functional Outcome of Post COVID-19 Syndrome in Older Adults. Cureus. 2021;13(8):17189.
- Cabrera Martimbianco AL, Pacheco RL, Bagattini ÂM, et al. Frequency, signs and symptoms, and criteria adopted for long COVID-19: A systematic review. Int J Clin Pract. 2021;75(10):14357.
- Conti P, Ronconi G, Caraffa A, et al. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J Biol Regul Homeost Agents. 2020;34(2):327-331.
- Clegg A, Young J, Iliffe S, et al. Frailty in elderly people. Lancet. 2013;381(9868):752-62.
- Escourrou E, Herault M, Gdoura S, Stillmunkés A, Oustric S, Chicoulaa B. Becoming frail: a major turning point in patients’ life course. Fam Pract. 2019 Mar 20;36(2):231-236. doi: 10.1093/fampra/cmy043.
- Chen X, Mao G, Leng SX. Frailty syndrome: an overview. Clin Interv Aging. 2014;9:433-41.
- Li H, Manwani B, Leng SX. Frailty, inflammation, and immunity. Aging Dis. 2011;2(6):466-73.
- T.R. Ministry of Health, General Directorate of Public Health, COVID-19 (SARS-CoV-2 Infection) Adult Patient Treatment [e-book]. 2021. [Internet]. Available from: https://covid19.saglik.gov.tr/TR-66301/covid- 19-rehberi.html. Accessed: 09.06.2022 (in Turkish)
- Morley JE, Malmstrom TK, Miller DK. A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging. 2012;16(7):601-8.
- Ma Y, Hou L, Yang X, et al. The association between frailty and severe disease among COVID-19 patients aged over 60 years in China: a prospective cohort study. BMC Med. 2020;18(1):274.
- Martín-Salvador A, Torres-Sánchez I, Sáez-Roca G, et al. Age group analysis of psychological, physical and functional deterioration in patients hospitalized for pneumonia. Arch Bronconeumol. 2015;51(10):496- 501.
- Salimi S, Hamlyn JM. COVID-19 and Crosstalk With the Hallmarks of Aging. J Gerontol A Biol Sci Med Sci. 2020;75(9):34-41.
- Schmaltz HN, Fried LP, Xue QL, et al. Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. J Am Geriatr Soc. 2005;53(5):747-54.
- Griffith DM, Lewis S, Rossi AG, et al; RECOVER Investigators. Systemic inflammation after critical illness: relationship with physical recovery and exploration of potential mechanisms. Thorax. 2016;71(9):820-9.
- Langmann GA, Perera S, Ferchak MA, et al. Inflammatory Markers and Frailty in Long-Term Care Residents. J Am Geriatr Soc. 2017;65(8):1777-1783.
- Leng SX, Xue QL, Tian J, et al. Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: results from the Women’s Health and Aging Studies I. Exp Gerontol. 2009;44(8):511-6.
- Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med. 2000;51:245-70.
- Henry BM, de Oliveira MHS, Benoit S, et al Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med. 2020;58(7):1021- 1028.
- Lagunas-Rangel FA. Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis. J Med Virol. 2020;92(10):1733-1734.
- Walston J, McBurnie MA, Newman A, et al. Cardiovascular Health Study. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med. 2002;162(20):2333-41.
- Varadhan R, Walston J, Cappola AR, et al. Higher levels and blunted diurnal variation of cortisol in frail older women. J Gerontol A Biol Sci Med Sci 2008; 63:190.
- Chen B, Liu W, Li M, et al. Frailty Pathogenesis, Assessment, and Management in Older Adults With COVID-19. Front Med (Lausanne). 2021;8:694367.
- Brummel NE, Girard TD, Pandharipande PP, et al. Prevalence and Course of Frailty in Survivors of Critical Illness. Crit Care Med. 2020;48(10):1419- 1426.
- Khan KT, Hemati K, Donovan AL. Geriatric Physiology and the Frailty Syndrome. Anesthesiol Clin. 2019;37(3):453-474.
- Ferrara MC, Zarcone C, Tassistro E, et al; STORM Long-COVID Team. Frailty and long-COVID: is COVID-19 responsible for a transition in frailty status among older adults who survived hospitalization for COVID-19? Aging Clin Exp Res. 2023 Feb;35(2):455- 461.
- Covino M, Russo A, Salini S, et al. Long-Term Effects of Hospitalization for COVID-19 on Frailty and Quality of Life in Older Adults ≥80 Years. J Clin Med. 2022 Sep 29;11(19):5787.
- Müller I, Mancinetti M, Renner A, et al. Frailty assessment for COVID-19 follow-up: a prospective cohort study. BMJ Open Respir Res. 2022 Apr;9(1):e001227.
Düzeltme:
Yaşlı Hastalarda Post-COVID Sendromunun Bir Diğer Yüzü: Sistemik Enflamasyona Bağlı Artan Kırılganlık
Yıl 2024,
Cilt: 7 Sayı: 2, 169 - 169, 31.08.2024
Gülbahar Darılmaz Yüce
,
Funda Salgür
,
Samra Kamilova
,
Özgün Çiçek
,
Matin Iskandarov
,
Meriç Yavuz Çolak
,
Gaye Ulubay
,
M. Şule Akçay
Düzeltme Notu
In the article titled "Another Face of the Post-COVID Syndrome in Elderly Patients: Increased Frailty Due to Systemic Inflammation" published in the Journal of Geriatric Science (Year: 2023, Volume: 6, Issue: 2), the ethics committee approval date was incorrectly stated as 30 March 2020. The correct date is 30 March 2022. The authors sincerely apologize for this oversight. This correction aims to amend the error in the original article.
Öz
Amaç: COVID-19’un yaşlı yetişkinlerde uzun süreli morbidite ve mortalite yaratan bir durum olduğu bilinmektedir. COVID-19 ve kırılganlık ilişkisi hakkında henüz yeterli bilgi yoktur. Çalışmamızda COVID-19’un uzun vadeli etkileri arasında sayılabilecek bir durum olan kırılganlığı arttırıp arttırmadığını araştırdık.
Gereç ve Yöntemler: Çalışmaya Başkent Üniversitesi Tıp Fakültesi Hastanesi COVID-19 İzolasyon Servisi’nde yatan 65 yaş üstü, COVID-19 PCR testi pozitif olan 73 hasta dahil edildi. Hastalar hafif-orta pnömoni, ağır pnömoni ve yoğun bakım ünitesine yatış gerektiren ciddi pnömoni olarak kategorize edildi. Hastalara yatışının ilk gününde FRAIL Frailty ölçeği uygulandı. Taburculuk sonrası 3. ay kontrolünde tekrar FRAIL Frailty ölçeği uygulandı. Hastaneye yatışın ilk günü ve taburculuk sonrası 3. ay kontrol FRAIL indeksleri karşılaştırıldı.
Bulgular: Çalışmamıza katılan hastaların %58,9’u erkek, %41,1’i kadındı. Ortalama yaşları 77,48±7,68 idi. Ortalama FRAIL skoru yatışın ilk günü 1,34±0,12 iken taburculuk sonrası 2,24±0,12 idi. İlk ve son FRAIL skorları arasındaki ortalama değişim %60,3 idi ve istatistiksel olarak anlamlıydı (p<0,001). FRAIL skorundaki değişim en fazla %95 ile yoğun bakım grubunda oldu (p<0,001).
Sonuç: COVID-19 sistemik inflamasyonu arttırarak kırılganlığın artmasına neden olur. Yaşlı hastalar COVID-19 sırasında ve sonrasında kırılganlık açısından değerlendirilmelidir.
Destekleyen Kurum
Bu çalışma Başkent Üniversitesi Araştırma Fonu tarafınca desteklenmiştir.
Kaynakça
- Marengoni A, Zucchelli A, Vetrano DL, et al. Beyond Chronological Age: Frailty and Multimorbidity Predict In-Hospital Mortality in Patients With Coronavirus Disease 2019. J Gerontol A Biol Sci Med Sci. 2021;76(3):38-15.
- Fulop T, Witkowski JM, Olivieri F, et al. The integration of inflammaging in age-related diseases. Semin. Immunol. 2018; 40:17–35.
- PS, Madhavan S, Pandurangan V. Prevalence, Pattern and Functional Outcome of Post COVID-19 Syndrome in Older Adults. Cureus. 2021;13(8):17189.
- Cabrera Martimbianco AL, Pacheco RL, Bagattini ÂM, et al. Frequency, signs and symptoms, and criteria adopted for long COVID-19: A systematic review. Int J Clin Pract. 2021;75(10):14357.
- Conti P, Ronconi G, Caraffa A, et al. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J Biol Regul Homeost Agents. 2020;34(2):327-331.
- Clegg A, Young J, Iliffe S, et al. Frailty in elderly people. Lancet. 2013;381(9868):752-62.
- Escourrou E, Herault M, Gdoura S, Stillmunkés A, Oustric S, Chicoulaa B. Becoming frail: a major turning point in patients’ life course. Fam Pract. 2019 Mar 20;36(2):231-236. doi: 10.1093/fampra/cmy043.
- Chen X, Mao G, Leng SX. Frailty syndrome: an overview. Clin Interv Aging. 2014;9:433-41.
- Li H, Manwani B, Leng SX. Frailty, inflammation, and immunity. Aging Dis. 2011;2(6):466-73.
- T.R. Ministry of Health, General Directorate of Public Health, COVID-19 (SARS-CoV-2 Infection) Adult Patient Treatment [e-book]. 2021. [Internet]. Available from: https://covid19.saglik.gov.tr/TR-66301/covid- 19-rehberi.html. Accessed: 09.06.2022 (in Turkish)
- Morley JE, Malmstrom TK, Miller DK. A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans. J Nutr Health Aging. 2012;16(7):601-8.
- Ma Y, Hou L, Yang X, et al. The association between frailty and severe disease among COVID-19 patients aged over 60 years in China: a prospective cohort study. BMC Med. 2020;18(1):274.
- Martín-Salvador A, Torres-Sánchez I, Sáez-Roca G, et al. Age group analysis of psychological, physical and functional deterioration in patients hospitalized for pneumonia. Arch Bronconeumol. 2015;51(10):496- 501.
- Salimi S, Hamlyn JM. COVID-19 and Crosstalk With the Hallmarks of Aging. J Gerontol A Biol Sci Med Sci. 2020;75(9):34-41.
- Schmaltz HN, Fried LP, Xue QL, et al. Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. J Am Geriatr Soc. 2005;53(5):747-54.
- Griffith DM, Lewis S, Rossi AG, et al; RECOVER Investigators. Systemic inflammation after critical illness: relationship with physical recovery and exploration of potential mechanisms. Thorax. 2016;71(9):820-9.
- Langmann GA, Perera S, Ferchak MA, et al. Inflammatory Markers and Frailty in Long-Term Care Residents. J Am Geriatr Soc. 2017;65(8):1777-1783.
- Leng SX, Xue QL, Tian J, et al. Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: results from the Women’s Health and Aging Studies I. Exp Gerontol. 2009;44(8):511-6.
- Ershler WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med. 2000;51:245-70.
- Henry BM, de Oliveira MHS, Benoit S, et al Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med. 2020;58(7):1021- 1028.
- Lagunas-Rangel FA. Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis. J Med Virol. 2020;92(10):1733-1734.
- Walston J, McBurnie MA, Newman A, et al. Cardiovascular Health Study. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med. 2002;162(20):2333-41.
- Varadhan R, Walston J, Cappola AR, et al. Higher levels and blunted diurnal variation of cortisol in frail older women. J Gerontol A Biol Sci Med Sci 2008; 63:190.
- Chen B, Liu W, Li M, et al. Frailty Pathogenesis, Assessment, and Management in Older Adults With COVID-19. Front Med (Lausanne). 2021;8:694367.
- Brummel NE, Girard TD, Pandharipande PP, et al. Prevalence and Course of Frailty in Survivors of Critical Illness. Crit Care Med. 2020;48(10):1419- 1426.
- Khan KT, Hemati K, Donovan AL. Geriatric Physiology and the Frailty Syndrome. Anesthesiol Clin. 2019;37(3):453-474.
- Ferrara MC, Zarcone C, Tassistro E, et al; STORM Long-COVID Team. Frailty and long-COVID: is COVID-19 responsible for a transition in frailty status among older adults who survived hospitalization for COVID-19? Aging Clin Exp Res. 2023 Feb;35(2):455- 461.
- Covino M, Russo A, Salini S, et al. Long-Term Effects of Hospitalization for COVID-19 on Frailty and Quality of Life in Older Adults ≥80 Years. J Clin Med. 2022 Sep 29;11(19):5787.
- Müller I, Mancinetti M, Renner A, et al. Frailty assessment for COVID-19 follow-up: a prospective cohort study. BMJ Open Respir Res. 2022 Apr;9(1):e001227.