A Newborn Case With Renal Vein Thrombosis Due to Double Mutations of Factor V Leiden and MTHFR

Yıl 2015, Cilt: 5 Sayı: 2, 135 - 139, 10.03.2015

Hakan Altın , Şenol Çitli Ahmet Akçay

https://doi.org/10.16899/ctd.88818

Öz

Newborns are more susceptible to thrombosis than adults due to their lower amount of anticoagulant and fibrinolytic system proteins.  Incidence of thrombosis rises with presence of the predisposing factors such as hypoxia , infection, dehydration, polycytemia, infants of diabetic mothers, intravenous catheter use, and prothrombotic genetic disorders. Renal vein thrombosis can lead to potentially serious health problems and clinically present with hematuria, renal failure, thrombocytopenia, hypertension, oliguria and palpable mass in the abdomen.  Although renal vein thrombosis is a rare disease of newborn its incidence has been increased in recent years. In this article we presented a newborn case with meconium aspiration syndrome and renal vein thrombosis with presence of the genetic predisposing factors as Factor V Leiden and MTHFR gene mutations.

 

Anahtar Kelimeler

New Born, Renal Vein Thrombosis, Gene Mutation

Faktör V Leiden ve Mthfr İkili Mutasyonu Bulunan Renal Ven Trombozlu Yenidoğan Olgusu

Öz

Yenidoğan bebeklerde eriskinlere göre antikoagulan ve fibrinolitik sistem protein düzeylerinin daha düşük olması nedeniyle tromboza yatkınlık mevcuttur. Hipoksi, enfeksiyon,  dehidratasyon, polisitemi, diyabetik anne bebeği, damar içi kateter kullanımı ve protrombotik genetik bozukluklar gibi hazırlayıcı faktörlerin varlığında tromboz sıklığı artmaktadır. Renal ven trombozu ciddi sağlık problemlerine yol açabilir ve klinik olarak hematüri, böbrek yetmezliği, trombositopeni, hipertansiyon, oligüri ve palpasyon ile batında ele gelen kitle seklinde ortaya çıkar. Renal ven trombozu yenidoğan döneminde oldukça nadir olarak görülmesine rağmen son yıllarda sıklığı giderek artmaktadır. Bu makalede Faktor V Leiden ve Metilentetrahidrofolat reduktaz (MTHFR) mutasyonlarının genetik predispozisyonunda   mekonyum aspirasyon sendromu ve renal ven trombozu gelişen bir yenidoğan olgusu sunulmuştur.

 

Anahtar Kelimeler

Yenidoğan, Renal Ven Trombozu, Gen Mutasyonu

Kaynakça

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