LAMIACEAE FAMİLYASINA AİT 37 TIBBİ BİTKİNİN HMG-KOA REDÜKTAZ İNHİBİTÖR AKTİVİTELERİ

Yıl 2020, Cilt: 5 Sayı: 3, 24 - 33, 31.12.2020

Serkan Yiğitkan Abdulselam Ertaş , Mehmet Fırat , Yeter Yeşil İlkay Erdoğan Orhan

Öz

3-Hidroksi-3-metil-glutaril-koenzim A (HMG-KoA) redüktaz enzimi kolesterol biyosentezinde görev alan anahtar enzimdir. Dolayısıyla HMG-KoA redüktaz inhibisyonu hiperkolesterolemi tedavisi için en önemli hedeflerden biridir. Diğer yandan, yeni ilaç keşfi araştırmalarında tıbbi bitkiler ve bunlardan izole edilen moleküller önemli bir yer tutmaktadır. Bu çalışmada, Türkiye’de yetişen ve daha önce bu enzime yönelik olarak üzerinde araştırma yapılmamış olan Lamiaceae familyasına ait 37 bitki taksonunun etanol ekstrelerinin in vitro HMG-KoA redüktaz enzim inhibisyon aktiviteleri ELISA mikroplak yöntemi kullanılarak araştırılmıştır. Taramamız sonucunda Salvia inhibitör etkili bulunan ekstreler, Salvia multicaulis Vahl. (% 61,66 ± 1,52) ve Salvia blepharochlaena Hedge & Hub.Mor. (% 55,21 ± 1,12) olarak tespit edilmiştir.

Anahtar Kelimeler

HMG-KoA Redüktaz, enzim inhibisyonu, Lamiaceae, hiperkolesterolemi

Destekleyen Kurum

Gazi Üniversitesi

Proje Numarası

02/2018-16

Teşekkür

Çalışmamızı 02/2018-16 proje kodu ile destekleyen Gazi Üniversitesi Bilimsel Araştırma Projeleri Birimine teşekkür ederiz.

Kaynakça

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