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Propolisin Kimyasal Bileşimi ve Biyolojik Etkileri

Yıl 2022, Cilt: 3 Sayı: 1, 14 - 32, 18.05.2022

Öz

Bal arısı (Apis mellifera L.) tarafından bitkilerden toplanan doğal bir ürün olan propolis; %45-50 flavonidlerden, %30-35 mum ve yağ asitlerinden, %10 esansiyel yağlardan, %5 polenden ve %5 organik bileşiklerden ve mineral maddelerden oluşmaktadır. İçeriği edinildiği kaynaklara, iklime, mevsime ve bekleme süresine bağlı olarak değişmektedir. Propolis hem yararlı hem de zararlı özellikler gösteren doğal bir üründür. Propolisin antioksidan, antikanser, antibakteriyel, antiviral, antifungal, antienflamatuar ve antiülser etkileri bulunduğu açıklanmıştır. Propolis içerdiği maddelere göre farklı alerjik komplikasyonlara, genotoksik ve antigenotoksik etkilere de sebep olabilmektedir. Bu derlemede propolisin kimyasal bileşimi ve biyolojik etkileri sunulmuştur.

Destekleyen Kurum

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Teşekkür

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Kaynakça

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  • [102] Tohamy, A.A., Abdella, E.M., Ahmed, R.R., and Ahmed, Y.K. (2014). Assessment of anti-mutagenic, anti-histopathologic and antioxidant capacities of Egyptian bee pollen and propolis extracts. Cytotechnology, 66(2), 283-297.
  • [103] Rocha, B.A., Bueno, P.C., Vaz, M.M., Nascimento, A.P., Ferreira, N.U., Moreno Gde, P., Rodrigues, M.R., Costa-Machado, A.R., Barizon, E.A., Campos, J.C., de Oliveira, P.F., Acesio Nde, O., Martins Sde, P., Tavares, D.C., and Berretta, A.A. (2013). Evaluation of a propolis water extract using a reliable RP-HPLC methodology and in vitro and in vivo efficacy and safety characterisation. Evidence-Based Complementary and Alternative Medicine, 2670451.
  • [104] de Lima, R.O., Bazo, A.P., Said, R.A., Sforcin, J.M., Bankova, V., Darros, B.R., and Salvadori, D.M. (2005). Modifying effect of propolis on dimethylhydrazine-induced DNA damage but not colonic aberrant crypt foci in rats. Environmental and Molecular Mutagenesis, 45(1), 8-16.
  • [105] Alıyazıcıoglu, Y., Demir, S., Turan, I., Cakıroglu, T. N., Akalın, I., Değer, O., and Bedir, A. (2011). Preventive and protective effects of Turkish propolis on H2O2-induced DNA damage in foreskin fibroblast cell lines. Acta Biologica Hungarica, 62(4), 388-396.
  • [106] Senedese, J.M., Rodrigues, A.R., Furtado, M.A., Faustino, V.D., Berretta, A.A., Marchetti, J.M., and Tavares, D.C. (2011). Assessment of the mutagenic activity of extracts of brazilian propolis in topical pharmaceutical formulations on mammalian cells in vitro and in vivo. Evidence-Based Complementary and Alternative Medicine, 315701.
  • [107] Pereira, A.D., de Andrade, S.F., de Oliveira Swerts, M.S., and Maistro, E.L. (2008). First in vivo evaluation of the mutagenic effect of Brazilian green propolis by comet assay and micronucleus test. Food and Chemical Toxicology, 46(7), 2580-2584.
  • [108] Valadares, B.L., Graf, U., and Spano, M.A. (2008). Inhibitory effects of water extract of propolis on doxorubicin-induced somatic mutation and recombination in Drosophila melanogaster. Food and Chemical Toxicology, 46(3), 1103-1110.
  • [109] Roberto, M.M., Jamal, C.M., Malaspina, O., and Marin-Morales, M.A. (2016). Antigenotoxicity and antimutagenicity of ethanolic extracts of Brazilian green propolis and its main botanical source determined by the Allium cepa test system. Genetics and Molecular Biology, 39(2), 257-269.
  • [110] Roberto, M.M., Matsumoto, S.T., Jamal, C.M., Malaspina, O., and Marin-Morales, M.A. (2016). Evaluation of the genotoxicity/mutagenicity and antigenotoxicity/antimutagenicity induced by propolis and Baccharis dracunculifolia, by in vitro study with HTC cells. Toxicol In Vitro, 33, 9-15.
  • [111] Rodrigues, C.R., Plentz, L.C., Marcucci, M.C., Dihl, R.R., and Lehmann, M. (2016). In vivo evaluation of mutagenic and recombinagenic activities of Brazilian propolis. Food and Chemical Toxicology, 96, 117-121.
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  • [113] Russo, A., Troncoso, N., Sanchez, F., Garbarino, J.A., and Vanella, A. (2006). Propolis protects human spermatozoa from DNA damage caused by benzo[a]pyrene and exogenous reactive oxygen species. Life Sciences, 78(13), 1401-1406.
  • [114] Benkovic, V., Knezevic, A.H., Dikic, D., Lisicic, D., Orsolic, N., Basic, I., Kosalec, I., and Kopjar, N. (2008). Radioprotective effects of propolis and quercetin in gamma-irradiated mice evaluated by the alkaline comet assay. Phytomedicine, 15(10), 851-858.
  • [115] Benković, V., Kopjar, N., Kneževic, A.H., Đikić, D., Bašić, I., Ramić, S., Viculin, T., Kneževic, F., and Orolić, N. (2008). Evaluation of radioprotective effects of propolis and quercetin on human white blood cells in vitro. Biological and Pharmaceutical Bulletin, 31(9), 1778-1785.
  • [116] Benkovic, V., Knezevic, A.H., Dikic, D., Lisicic, D., Orsolic, N., Basic, I., and Kopjar, N. (2009). Radioprotective effects of quercetin and ethanolic extract of propolis in gamma-irradiated mice. Archives of Industrial Hygiene and Toxicology, 60(2), 129-138.
  • [117] Santos, G.S., Tsutsumi, S., Vieira, D.P., Bartolini, P., and Okazaki, K. (2014). Effect of Brazilian propolis (AF-08) on genotoxicity, cytotoxicity and clonogenic death of Chinese hamster ovary (CHO-K1) cells irradiated with (60)Co gamma-radiation. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 762, 17-23.
  • [118] Benković, V., Knezevic, A.H., Orsolic, N., Basic, I., Ramic, S., Viculin, T., Knezevic, F., and Kopjar, N. (2009). Evaluation of radioprotective effects of propolis and its flavonoid constituents: In vitro study on human white blood cells. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 23(8), 1159-1168.
  • [119] Yalçın, C.O., Aliyazıcıoğlu, Y., Demir, S., Turan, I., Bahat, Z., Msır, S., and Değer, O. (2016). Evaluation of the radioprotective effect of Turkish propolis on foreskin fibroblast cells. Journal of Cancer Research and Therapeutics, 12(2), 990-997.
  • [120] Barnes, J.L., Zubair, M., John, K., Poirier, M.C., and Martin, F.L. (2018). Carcinogens and DNA damage. Biochemical Society Transactions, 45(5), 1213-1224.
  • [121] De Flora, S. (1998). Mechanisms of inhibitors of mutagenesis and carcinogenesis. Mutation Research, 402, 151-158.
  • [122] Kada, T., Inoue, T., Ohta, T., and Shirasu, Y. (1986). Antimutagens and their modes of action. In Antimutagenesis and Anticarcinogenesis Mechanisms, 1, 181-196.
  • [123] Turan, I., Değer, O., Aliyazıcıoğlu, Y., Demir, S., Kılınç, K., and Sümer, A. (2015). Effects of Turkish propolis on expression of hOGG-1 and NEIL-1. Turkish Journal of Medical Sciences, 45(4), 804-811.
  • [124] Von Borstel, R.C. and Higgins, J.A. (1998). Janus carcinogens and mutagens. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 402(1-2), 321-329.
Toplam 122 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Derlemeler
Yazarlar

Beyza Merve Yıldız 0000-0003-1231-4990

Fatma Ünal 0000-0002-7468-6186

Proje Numarası -
Yayımlanma Tarihi 18 Mayıs 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 3 Sayı: 1

Kaynak Göster

APA Yıldız, B. M., & Ünal, F. (2022). Propolisin Kimyasal Bileşimi ve Biyolojik Etkileri. Gazi Üniversitesi Fen Fakültesi Dergisi, 3(1), 14-32.
AMA Yıldız BM, Ünal F. Propolisin Kimyasal Bileşimi ve Biyolojik Etkileri. GÜFFD. Mayıs 2022;3(1):14-32.
Chicago Yıldız, Beyza Merve, ve Fatma Ünal. “Propolisin Kimyasal Bileşimi Ve Biyolojik Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi 3, sy. 1 (Mayıs 2022): 14-32.
EndNote Yıldız BM, Ünal F (01 Mayıs 2022) Propolisin Kimyasal Bileşimi ve Biyolojik Etkileri. Gazi Üniversitesi Fen Fakültesi Dergisi 3 1 14–32.
IEEE B. M. Yıldız ve F. Ünal, “Propolisin Kimyasal Bileşimi ve Biyolojik Etkileri”, GÜFFD, c. 3, sy. 1, ss. 14–32, 2022.
ISNAD Yıldız, Beyza Merve - Ünal, Fatma. “Propolisin Kimyasal Bileşimi Ve Biyolojik Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi 3/1 (Mayıs 2022), 14-32.
JAMA Yıldız BM, Ünal F. Propolisin Kimyasal Bileşimi ve Biyolojik Etkileri. GÜFFD. 2022;3:14–32.
MLA Yıldız, Beyza Merve ve Fatma Ünal. “Propolisin Kimyasal Bileşimi Ve Biyolojik Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi, c. 3, sy. 1, 2022, ss. 14-32.
Vancouver Yıldız BM, Ünal F. Propolisin Kimyasal Bileşimi ve Biyolojik Etkileri. GÜFFD. 2022;3(1):14-32.