Investigation of The Effects of FOLFOX and CAPOX Chemotherapy Protocols on CEA and CA 19-9 in Colon Cancer

Yıl 2023, Cilt: 12 Sayı: 4, 2015 - 2020, 26.12.2023

Birsen Ecem İbabay , Elif Ercan , Ahmet Çarhan

https://doi.org/10.37989/gumussagbil.1225732

Öz

The most common markers used in the diagnosis of the colon cancer are CEA and CA 19-9. Chemotherapy is applied as an adjuvant and a neo-adjuvant treatment in colon cancer.
Our aim was to investigate the effects of FOLFOX and CAPOX on CEA and CA 19-9 levels before and after chemotherapy in different patient groups.
The CEA and CA 19-9 values before and after chemotherapy for the 60 patients diagnosed with metastatic colon cancer having FOLFOX or CAPOX therapy age over 18 whom hospitalised between 2017-2020, were used.
The mean value for CA 19-9 of T0 for FOLFOX receiving group was calculated as 263.71 ± 709.87 U/ml and was 119.57 ± 246.34 U/ml of for the 3rd month. The mean value for CEA for receiving FOLFOX was calculated as 76.11 ± 204.22 ng/g at T0, and 50.53 ± 142.50 ng/g at the 3rd month. The mean value of CEA for receiving CAPOX was calculated as 139.62 ± 388.87 ng/g at T0, and 117.05 ± 272.08 ng/g at the 3rd month. Intertemporal CEA levels of individuals receiving CAPOX were found to show significant differences (p=0.074). CA 19-9 mean of T0 was calculated as 218.43 ± 605.53 U/ml and the 3rd month mean of 174.40 ± 465.61 U/ml of the patients receiving CAPOX. It was found that the intertemporal values of the individuals in terms of CA 19-9 levels were not statistically significant (p=0.649).
In conclusion, CA 19-9 and CEA levels of the patients decreased even more in the 3rd month when treated with FOLFOX. The decrease in CEA was found to be more significant. In terms of CAPOX treatment, the interquartile range T0 and the 3rd month levels did not show a significant difference, statistically (p=0.143 and p=0.089).

Anahtar Kelimeler

CA 19-9, CAPOX, CEA, Colon Cancer, FOLFOX

Kolon Kanseri Hastalarında FOLFOX ve CAPOX’un CEA ve CA 19-9 Üzerine Etkisinin Araştırılması

Öz

Kolon kanseri tanısında en sık kullanılan belirteçler CEA ve CA 19-9'dur. Kolon kanserinde Kemoterapi uygulaması adjuvan ve neo-adjuvan olarak yapılmaktadır.
Çalışmadaki amacımız, FOLFOX ve CAPOX 'un farklı hasta gruplarında kemoterapi öncesi ve sonrası CEA ve CA 19-9 düzeylerine etkilerini araştırmaktı.
2017-2020 yılları arasındaki, 18 yaş üstü FOLFOX veya CAPOX kemoterapi protokolü alan, metastatik kolon kanseri tanısı almış 60 hastanın kemoterapi öncesi (T0) ve 3. aydaki CEA ve CA 19-9 değerleri kullanılmıştır.
FOLFOX tedavisi alan hastaların ortalama CA 19-9 değerleri T0'da 263,71 ± 709,87 U/mL ve 3.ayda 119,57 ± 246,34 U/mL, CEA değerleri T0'da 76,11 ± 204,22 ng/gr ve 3.ayda 50,53 ± 142,50 ng/gr olarak hesaplanmıştır. CAPOX alan grupta ortalama CEA değeri T0'da 139,62 ± 388,87 ng/gr ve 3.ayda 117,05 ± 272,08 ng/gr olarak hesaplanmıştır. CAPOX alan bireylerde başlangıç ve 3.ayda CEA düzeylerindeki farklılıklar anlamlı bulunmuştur (p=0,074). CAPOX alan hastaların CA 19-9 ortalaması T0’da 218,43 ± 605,53 U/mL ve 3.ayda 174,40 ± 465,61 U/mL olarak hesaplanmıştır. Bireylerin başlangıç ve 3.ay CA 19-9 değerleri istatistiksel olarak anlamlı bulunmamıştır (p=0,649).
Sonuç olarak, FOLFOX ile tedavi edilen hastaların CA 19-9 ve CEA seviyelerinin 3. ayda daha da düştüğü bulunmuş ve CEA seviyelerindeki azalma daha anlamlı bulunmuştur. CAPOX tedavisi alanlarda, çeyrekler arası başlangıç ve 3. ay seviyeleri istatistiksel olarak anlamlı bulunmamıştır (p=0,143 ve p=0,089).

Anahtar Kelimeler

CA 19-9, CAPOX, CEA, FOLFOX, Kolon Kanseri

Kaynakça

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