Candida Enfeksiyonlarında Probiyotik: Tek Merkez Yenidoğan Yoğun Bakım Ünitesinde On Yıllık Tecrübe

Yıl 2022, Cilt: 14 Sayı: 2, 73 - 82, 27.10.2022

Ferda Özlü , Hüseyin Şimşek , Hacer Yapıcıoğlu Aslıhan Candevir

Öz

Amaç: Candida türleri, yenidoğan popülasyonunda en önemli morbidite ve mortalite nedenlerinden biridir. Yenidoğanlarda kandida enfeksiyonlarında probiyotik kullanımı tartışmalıdır. Bu çalışmanın amacı yenidoğan yoğun bakım ünitesinde kandida enfeksiyonlarını değerlendirmektir.
Metod: YYBÜ'de Candida enfeksiyonu için risk faktörlerini belirlemek için retrospektif tek merkezli, karşılaştırmalı bir vaka kontrol çalışması tasarlanmıştır. Çalışmaya alınan hastaların tümü, çalışma süresi boyunca en az 72 saat YYBÜ'de bulunan yenidoğanlardı. Her vaka için negatif kan kültürü olan 2 kontrol vakası 3 faktör açısından eşleştirildi: gebelik yaşı, doğum ağırlığı, hastanede kalış süresi (1 hafta içinde).
Sonuç: 7696 yenidoğan on bir yıl boyunca YYBÜ'de 72 saatten fazla yatırıldı ve 51 vaka (% 0,66) kandida enfeksiyonu ile takip edildi. Kontrol grubunda probiyotik kullanımı daha yüksekti. Cerrahi müdahaleler, santral venöz hatlar ve parenteral beslenme süresi, çoklu antibiyotik kullanımları kandida enfeksiyonları için risk faktörleri olarak bulundu.
Sonuç: YYBÜ'de kandida enfeksiyonlarının insidansını azaltmak için çoklu antibiyotiklerin genel kullanımını azaltmanın yanı sıra probiyotik kullanımını artırmaya, kateter bakımını iyileştirmeye etkin bir şekilde odaklanmalıyız. Probiyotiklerin Candida enfeksiyonlarına karşı koruyucu etkisi olabilir.

Anahtar Kelimeler

yenidoğan, kandida enfeksiyonu, risk faktörleri, probiyotikler

Probiotics in Candida Infections: Ten Years Experience in Single Neonatal Intensive Care Unit

Öz

Objectives: Candida species are one of the most important causes of morbidity and mortality in the neonatal population. The probiotic use is not well documented in candida infections in neonates. The aim of this study was to evaluate candida infections in neonatal intensive care unit.
Methods: A retrospective single-center, matched, case-control study was designed to identify individual risk factors for Candida infection in the NICU. Patients enrolled in the analysis were all neonates who were in the NICU during the study period for at least 72 h. For each case, 2 control cases with negative blood culture were matched on 3 factors: gestational age, birth weight, hospitalization time (within 1week compared to case patients).
Results: 7696 newborns were admitted to and hospitalized >72 h in the NICU for eleven years and 51 cases (0.66 %) were followed with candida infection. Probiotic usage was higher in control group. Surgical interventions, central venous lines and parenteral nutrition duration, multiple antibiotic usages were found to be risk factors for candida infections.
Conclusion: In NICU we should effectively focus on increasing using of probiotics, besides decreasing the overall use of multiple antibiotics, improving catheter care to reduce the incidence of candida infections. Probiotics might have protective effect against candida infections.

Anahtar Kelimeler

neonate, candida infection, risk factors, probiotics

Kaynakça

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