İskemi Reperfüzyon Hasarında Stres ve Hücre Ölümü

Yıl 2022, Cilt: 4 Sayı: 2, 64 - 73, 29.06.2022

Ümmü Gülşen Bozok , Ayşegül Küçük , Mustafa Arslan

https://doi.org/10.52827/hititmedj.1008303

Cited By: 2

Öz

İskemi-reperfüzyon hasarı, miyokard enfarktüsü, iskemik inme, akut böbrek hasarı, periferik arter hastalığı, orak hücre anemisi dahil olmak üzere çok çeşitli patolojilerin morbidite ve mortalitesinde rol oynar. İskemide kan akımındaki azalmanın derecesine ve süresine bağlı olarak hücreler metabolik ihtiyaçlarını karşılayamaz. Hızlı reperfüzyon, oksijen açlığı çeken hücrelerin kurtarılması için gerekli olmasına rağmen, hücrede oluşan oksijen paradoksu hücreleri strese sürükler. Reperfüzyon ile birlikte ortaya çıkan stres yanıtı sınırlandırılamazsa hücre ölüm programları aktive olarak hücre ölür. Bu derlemenin amacı iskemi reperfüzyon hasarında rol oynayan hücresel stres mekanizmalarını ve ölüm programlarını tanımlamaktır.

Anahtar Kelimeler

Hücre ölüm yolları, iskemi-reperfüzyon hasarı, stres mekanizmaları

Kaynakça

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