The effect of coenzyme Q10 on blood plasma nitric oxide and total antioxidant capacity levels in hypothyroidism-induced rats

Yıl 2021, Cilt: 5 Sayı: 1, 19 - 26, 30.04.2021

Cemşah Yazıcı , Tufan Keçeci , Durmuş Hatipoğlu

https://doi.org/10.30704/http-www-jivs-net.851210

Cited By: 1

Öz

In this study, the effect of coenzyme Q10 (CoQ10) on nitric oxide (NO) and total antioxidant (TAS) capacity in rats for which experimentally hypothyroidism was induced through PTU was investigated. A total of 32 healthy male Wistar Albino rats weighing 300-350g, approximately 12 weeks old, were used as animal material in the study. . Rats were divided into 4 experimental groups as control (K), Coenzyme Q10 (C), Hypothyroidism (H), and Coenzyme Q10 + Hypothyroidism (CH). During the trial period of three weeks, 3mg CoQ10 (10mg/kg/day) was dissolved in 0.3 ml of maize oil and intraperitoneally administered for each animal in group C. In group H, PTU has added to drinking water daily at a weight/volume (w/v) ratio of %0.05. In the HC group, coenzyme Q10 was administered intraperitoneally and PTU was administered with drinking water at a rate of %0.05. TT4, TT3, and TSH levels were determined in serum samples and NO and TAS levels in plasma samples. In the present study; the highest plasma NO level among the groups was determined in group H (p<0.05) and there was no significant difference between other groups (H, C, HC) (p>0.05). The plasma TAS value of group H was found to be significantly higher than the same value in the K, C and HC groups (p<0.05). The plasma TAS level in group C had no difference from the same value in the HC group (p>0.05), although it was higher than the same value of group K (p<0.05). As a result, it was found to cause oxidative stress in hypothyroidism-induced rats with a particular increase in plasma NO levels, and CoQ10 was found to be effective in normalizing the increased plasma NO level due to hypothyroidism.

Anahtar Kelimeler

hypothyroidism, coenzyme q10, nitric oxide, total antioxidant capacity, rats

Destekleyen Kurum

BAP

Proje Numarası

19202014

Kaynakça

• AL-Megrin, W. A., Soliman, D., Kassab, R. B., Metwally, D. M., Ahmed E. Abdel Moneim, & El-Khadragy, M. F. (2020). Coenzyme Q10 Activates the Antioxidant Machinery and Inhibits the Inflammatory and Apoptotic Cascades Against Lead Acetate-Induced Renal Injury in Rats. Frontiers in Physiology,7,11:64.
• Bath, S. C., Steer, C. D., Golding, J., Emmett, P., & Rayman, M. P. (2013). Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: results from the Avon Longitudinal Study of Parents and Children (ALSPAC). The Lancet, 382(9889), 331-337.
• Bhagavan, H. N., Chopra, R. K., Craft, N. E., Chitchumroonchokchai, C., & Failla, M. L. (2007). Assessment of coenzyme Q10 absorption using an in vitro digestion-Caco-2 cell model. International Journal of Pharmaceutics, 333(1), 112-117.
• Biondi, B., & Cooper, D. S. (2019). Thyroid hormone therapy for hypothyroidism. Endocrine, 66(1), 18-26.
• Brown, G. C., & Borutaite, V. (2012). There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells. Mitochondrion, 12(1), 1-4.
• Chainy, G. B., & Sahoo, D. K. (2020). Hormones and oxidative stress: an overview. Free Radical Research, 54(1), 1-26.
• Cooke, M., Iosia, M., Buford, T., Shelmadine, B., Hudson, G., Kerksick, C., Rasmussen, C., Greenwood, M., Leutholtz, B., & Willoughby, D. (2008). Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. Journal of the International Society of Sports Nutrition, 5(1), 8.
• Cooper, D. S., Kıeffer, D., Halpern, R., Saxe, V., Mover, H., Maloof, F., & Rıdgway, E. C. (1983). Propylthiouracil (PTU) Pharmacology in the rat,II. effects of PTU on thyroid function. Endocrinology, 113(3), 921-928.
• Costantini, F., Pierdomenico, S. D., Cesare, D. D., De Remigis, P., Bucciarelli, T., Bittolo-Bon, G., Cazzolato, G., Nubile, G., Guagnano, M. T., & Sensi, S. (1998). Effect of thyroid function on LDL oxidation. Arteriosclerosis, thrombosis, and vascular biology, 18(5), 732-737.
• Das, K., & Chainy, G. (2001). Modulation of rat liver mitochondrial antioxidant defence system by thyroid hormone. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1537(1), 1-13.
• Di Meo, S., Reed, T. T., Venditti, P., & Victor, V. M. (2016). Role of ROS and RNS sources in physiological and pathological conditions. Oxidative Medicine and Cellular Longevity, 2016.
• Fernández-Vizarra, E., Enriquez, J. A., Pérez-Martos, A., Montoya, J., & Fernández-Silva, P. (2008). Mitochondrial gene expression is regulated at multiple levels and differentially in the heart and liver by thyroid hormones. Current Genetics, 54(1), 13.
• Franco, M., Chávez, E., & Pérez-Méndez, O. (2011). Pleiotropic effects of thyroid hormones: learning from hypothyroidism. Journal of thyroid research, 2011, 321030-321030.
• Freinbichler, W., Colivicchi, M. A., Stefanini, C., Bianchi, L., Ballini, C., Misini, B., Weinberger, P., Linert, W., Varešlija, D., & Tipton, K. F. (2011). Highly reactive oxygen species: detection, formation, and possible functions. Cellular and Molecular Life Sciences, 68(12), 2067-2079.
• Gholami, M., Zarei, P., Sadeghi Sedeh, B., Rafiei, F., & Khosrowbeygi, A. (2018). Effects of coenzyme Q10 supplementation on serum values of adiponectin, leptin, 8-isoprostane and malondialdehyde in women with type 2 diabetes. Gynecological Endocrinology, 34(12), 1059-1063.
• Gholnari, T., Aghadavod, E., Soleimani, A., Hamidi, G. A., Sharifi, N., & Asemi, Z. (2018). The effects of coenzyme q10 supplementation on glucose metabolism, lipid profiles, inflammation, and oxidative stress in patients with diabetic nephropathy: a randomized, double-blind, placebo-controlled trial. Journal of the American College of Nutrition, 37(3), 188-193.
• Guerrero, A., Pamplona, R., Portero-Otín, M., Barja, G., & López-Torres, M. (1999). Effect of thyroid status on lipid composition and peroxidation in the mouse liver. Free Radical Biology and Medicine, 26(1-2), 73-80.
• Hall, J. E., & Hall, M. E. (2020). Guyton and Hall textbook of medical physiology e-Book. Elsevier Health Sciences.
• Hermenegildo, C., Medina, P., Peiró, M., Segarra, G., Vila, J. M., Ortega, J. n., & Lluch, S. (2002). Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in hyperthyroid patients. The Journal of Clinical Endocrinology & Metabolism, 87(12), 5636-5640.
• Hosseini-Zijoud, S.-M., Ebadi, S. A., Goodarzi, M. T., Hedayati, M., Abbasalipourkabir, R., Mahjoob, M. P., Poorolajal, J., Zicker, F., & Sheikh, N. (2016). Lipid peroxidation and antioxidant status in patients with medullary thyroid carcinoma: A case-control study. Journal of clinical and diagnostic research, 10(2), BC04.
• Jorat, M. V., Tabrizi, R., Kolahdooz, F., Akbari, M., Salami, M., Heydari, S. T., & Asemi, Z. (2019). The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: A systematic review and meta-analysis of randomized controlled trials. Inflammopharmacology, 27(2), 233-248.
• Joshi, B., Singh, S., Saini, A., Gupta, S., & Vanishree, B. (2018). A study of lipid peroxidation and total antioxidant capacity in hyperthyroid and hypothyroid female subjects. Galore International Journal of Health Sciences and Research, 3(4), 1-8.
• Kwong, L. K., Kamzalov, S., Rebrin, I., Bayne, A.-C. V., Jana, C. K., Morris, P., Forster, M. J., & Sohal, R. S. (2002). Effects of coenzyme Q10 administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radical Biology and Medicine, 33(5), 627-638.
• Lee, B.-J., Huang, Y.-C., Chen, S.-J., & Lin, P.-T. (2012). Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition, 28(3), 250-255.
• Littarru, G. P., & Tiano, L. (2010). Clinical aspects of coenzyme Q10: an update. Nutrition, 26(3), 250-254.
• Mancini, A., De Marinis, L., Calabrò, F., Sciuto, R., Oradei, A., Lippa, S., Sandric, S., Littarru, G., & Barbarino, A. (1989). Evaluation of metabolic status in amiodarone-induced thyroid disorders: plasma coenzyme Q 10 determination. Journal of Endocrinological İnvestigation, 12(8), 511-516.
• Mancini, A., Festa, R., Raimondo, S., Pontecorvi, A., & Littarru, G. P. (2011). Hormonal influence on coenzyme Q10 levels in blood plasma. International Journal of Molecular Sciences, 12(12), 9216-9225.
• Messerah, M., Saoudi, M., Boumendjel, A., Baulakoud, M., & El Feki, A. (2011). Oxidative stress induced by thyroid dysfunction in rat erythrocytes and hearth. Environmental Toxicology and Pharmacology, 31, 33-41.
• Moazen, M., Mazloom, Z., Ahmadi, A., Dabbaghmanesh, M., & Roosta, S. (2015). Effect of coenzyme Q10 on glycaemic control, oxidative stress and adiponectin in type 2 diabetes. Journal of Pakistan Medical Association, 65(4), 404-408.
• Mortezaee, K., Ahmadi, A., Haghi-Aminjan, H., Khanlarkhani, N., Salehi, E., Shabani Nashtaei, M., Farhood, B., Najafi, M., & Sahebkar, A. (2019). Thyroid function following breast cancer chemotherapy: A systematic review. Journal of Cellular Biochemistry, 120(8), 12101-12107.
• Ogura, F., Morii, H., Ohno, M., Ueno, T., Kitabatake, S., Hamada, N., & Ito, K. (1980). Serum coenzyme Q10 levels in thyroid disorders. Hormone and Metabolic Research, 12(10), 537-540.
• Pandolfi, C., Ferrari, D., Stanic, I., & Pellegrini, L. (1994). Circulating levels of CoQ10 in hypo-and hyperthyroidism. Minerva Endocrinologica, 19(3), 139-142.
• Paradies, G., Ruggiero, F., Petrosillo, G., & Quagliariello, E. (1994). Enhanced cytochrome oxidase activity and modification of lipids in heart mitochondria from hyperthyroid rats. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1225(2), 165-170.
• Pascual, A., & Aranda, A. (2012). Thyroid hormone receptors, cell growth and differentiation. Biochimica et Biophysica Acta, 1830.
• Paunović, M. G., Matić, M. M., Ognjanović, B. I., & Saičić, Z. S. (2017). Antioxidative and haematoprotective activity of coenzyme Q10 and vitamin E against cadmium-induced oxidative stress in Wistar rats. Toxicology and Industrial Health, 33(10), 746-756.
• Pereira, B., Rosa, L. C., Safi, D., Bechara, E., & Curi, R. (1994). Control of superoxide dismutase, catalase and glutathione peroxidase activities in rat lymphoid organs by thyroid hormones. Journal of Endocrinology, 140(1), 73-77.
• Quiles, J. L., Varela-López, A., Navarro-Hortal, M. D., & Battino, M. (2020). Coenzyme Q, mtDNA and Mitochondrial Dysfunction During Aging. In G. López Lluch (Ed.), Coenzyme Q in Aging (pp. 191-225). Cham, Switzerland: Springer International Publishing.
• Resch, U., Helsel, G., Tatzber, F., & Sinzinger, H. (2002). Antioxidant status in thyroid dysfunction. Clinical Chemistry and Laboratory Medicine, 40(11), 1132-1134.
• Saini, R. (2011). Coenzyme Q10: The essential nutrient. Journal of Pharmacy and Bioallied Sciences, 3(3), 466-467.
• Santoro, M. M. (2020). The Antioxidant Role of Non-mitochondrial CoQ10: Mystery solved! Cell Metabolism, 31(1), 13-15.
• Sarandol, A., Sarandol, E., Eker, S. S., Karaagac, E. U., Hizli, B. Z., Dirican, M., & Kirli, S. (2006). Oxidation of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 30(6), 1103-1108.
• Sawashita, J., Zhe, X., & Higuchi, K. (2020). Reduced coenzyme Q10 decelerates senescence and age-related hearing loss in senescence-accelerated mice by activating mitochondrial functions. In G. López Lluch (Ed.), Coenzyme Q in Aging (pp. 169-187). Cham, Switzerland: Springer International Publishing.
• Sayıner, S., & Kısmalı, G. (2016). Koenzim Q ve hastalıklar ile ilişkisi. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 11(2).
• Scheffler, I. E. (2011). Mitochondria. New Jersey, US: John Wiley & Sons.
• Schmid, C., Zwimpfer, C., Brändle, M., Krayenbühl, P.-A., Zapf, J., & Wiesli, P. (2006). Effect of thyroxine replacement on serum IGF-I, IGFBP-3 and the acid-labile subunit in patients with hypothyroidism and hypopituitarism. Clinical Endocrinology, 65(6), 706-711.
• Schönfeld, P., Wiêckowski, M. R., & Wojtczak, L. (1997). Thyroid hormone-induced expression of the ADP/ATP carrier and its effect on fatty acid-induced uncoupling of oxidative phosphorylation. FEBS letters, 416(1), 19-22.
• Singh, R. B., Shinde, S. N., Chopra, R. K., Niaz, M. A., Thakur, A. S., & Onouchi, Z. (2000). Effect of coenzyme Q10 on experimental atherosclerosis and chemical composition and quality of atheroma in rabbits. Atherosclerosis, 148(2), 275-282.
• Stocker, R. (2007). Coenzyme Q10. Reviewed, Linus Pauling Institute Micronutrient Research for Optimum Health.
• Taylor, P. N., Albrecht, D., Scholz, A., Gutierrez-Buey, G., Lazarus, J. H., Dayan, C. M., & Okosieme, O. E. (2018). Global epidemiology of hyperthyroidism and hypothyroidism. Nature Reviews Endocrinology, 14(5), 301.
• Taylor, P. N., Okosieme, O. E., Dayan, C. M., & Lazarus, J. H. (2014). Impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis. European Journal of Endocrinology, 170(1), 1-15.
• Venditti, P., De Rosa, R., & Di Meo, S. (2003). Effect of thyroid state on susceptibility to oxidants and swelling of mitochondria from rat tissues. Free Radical Biology and Medicine, 35(5), 485-494.
• Venditti, P., & Di Meo, S. (2006). Thyroid hormone-induced oxidative stress. Cellular and Molecular Life Sciences, 63(4), 414-434.
• Venediktova, N. I., Mashchenko, O. V., Talanov, E. Y., Belosludtseva, N. V., & Mironova, G. D. (2020). Energy metabolism and oxidative status of rat liver mitochondria in conditions of experimentally induced hyperthyroidism. Mitochondrion, 52,190-196.
• Verma, M., Dahiya, K., Ghalaut, V. S., Soni, A., Singh, J., & Dhupper, V. (2013). Comparative study of ischemia modified albumin and nitric oxide in hyperthyroidism. American Journal of Physiology, Biochemistry and Pharmacology, 3(1), 1-4.
• Yilmaz, S., Ozan, S., Benzer, F., & Canatan, H. (2003). Oxidative damage and antioxidant enzyme activities in experimental hypothyroidism. Cell Biochemistry and Function, 21(4),325-230.
• Zimmermann, M. B. (2009). Iodine Deficiency. Endocrine Reviews, 30(4), 376-408.