Synthesis, Antibacterial Activity and Photophysical Properties of Bis-benzamide derivatives

Yıl 2021, Cilt: 41 Sayı: 3, 143 - 149, 01.09.2021

Günseli Bobuş Alkaya , Çağla Efeoğlu , İrem Acar , Ergin Yalçın , Fadime Nazlı Dincer Kaya , Yahya Nural

https://doi.org/10.52794/hujpharm.993718

Öz

In this study, N,N’-(dodecane-1,12-diyl)bis(2,4-dichlorobenzamide) and N,N’- (dodecane-1,12-diyl)bis(4-bromobenzamide) as new bis-benzamides were syn- thesized by reaction of 1,12-diaminododecane and two different acyl chloride compounds in 88% and 92% yield, respectively. Their molecular structures were characterized using 1H NMR, 13C NMR and FT-IR techniques. Antibacterial activities of the synthesized compounds were screened against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 strains. Moreover, pho- tophysical properties of the products in CH Cl and CHCl were investigated us-
2 2 3
ing UV-vis spectroscopy. The compound 3a exhibited positive solvatochromism
about 31 nm by increasing of solvent polarity.

Anahtar Kelimeler

Antibacterial activity, Bis-benzamide, Photophysical property

Destekleyen Kurum

Mersin University Research Fund

Proje Numarası

BAP 2020-1-AP5-4097

Teşekkür

This work was funded by Mersin University Research Fund (Project No: BAP 2020-1-AP5-4097).

Bis-benzamid Türevlerinin Sentezi, Antibakteriyel Aktivitesi ve Fotofiziksel Özellikleri

Öz

Bu çalışmada, 1,12-diaminododekan ve iki farklı açil klorür bileşiğinin reaksiyonu ile N,N'-(dodekan-1,12-diil)bis(2,4-diklorobenzamid) ve N,N'-(dodekan-1,12-diil)bis(4-bromobenzamid) olmak üzere yeni bis-benzamidler sırasıyla %88 ve %92 verimle sentezlendi. Moleküler yapıları 1H NMR, 13C NMR ve FT-IR teknikleri kullanılarak karakterize edildi. Sentezlenen bileşiklerin antibakteriyel aktiviteleri Staphylococcus aureus ATCC 25923 ve Escherichia coli ATCC 25922 suşlarına karşı tarandı. Ayrıca, CH2Cl2 ve CHCl3 içindeki ürünlerin fotofiziksel özellikleri UV-vis spektroskopisi kullanılarak incelendi. Bileşik 3a, çözücü polaritesinin artmasıyla yaklaşık 31 nm'de pozitif solvatokromizm gösterdi.

Anahtar Kelimeler

Antibakteriyel aktivite, Bis-benzamid, Fotofiziksel özellik

Proje Numarası

BAP 2020-1-AP5-4097

Kaynakça

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