The Use of Valproic Acid in the Treatment of Epilepsy and Its Determination in Biological Matrices

Yıl 2022, Cilt: 42 Sayı: 3, 199 - 207, 01.09.2022

Oğuz Özbek , Ömer Işıldak

https://doi.org/10.52794/hujpharm.1062609

Öz

Epilepsy is a chronic neurological disease and its treatment is long–term or lifelong. Anti–epileptic drugs are important pharmacological agents used in the treatment of epilepsy. The anti–epileptic agent selected to be used in the epilepsy treatment should have as little as possible side effects and prevent the development of seizures. Valproic acid is a broad spectrum drug that is highly effective in the treatment of almost all epileptic seizures. It is widely used around the world due to its reliable profile. The therapeutic level of valproic acid in the human blood should be monitored throughout treatment. Therefore, valproic acid testing procedures in different biological samples have been proposed using various analytical methods. In this review, the analytical methods reported for the determination of valproic acid in biological samples and the performance characteristics of these methods are mentioned.

Anahtar Kelimeler

Epilepsy, valproic acid, anti–epileptic, analytical methods

Epilepsi Tedavisinde Valproik Asit Kullanımı ve Biyolojik Matrislerdeki Tayini

Öz

Epilepsi kronik nörolojik bir hastalıktır ve tedavisi uzun süreli veya ömür boyu sürmektedir. Anti–epileptik ilaçlar epilepsi tedavisinde kullanılan önemli farmakolojik ajanlardır. Epilepsi tedavisinde kullanılmak üzere seçilen anti–epileptik ajan, mümkün olduğunca az yan etkiye sahip olmalı ve nöbet gelişimini engellemelidir. Valproik asit neredeyse tüm epileptik nöbetlerin tedavisinde oldukça etkili olan geniş spektrumlu bir ilaçtır. Güvenilir profili nedeniyle dünya genelinde oldukça yaygın olarak kullanılmaktadır. Tedavi boyunca insan kanındaki valproik asidin terapötik seviyesi izlenmelidir. Bu nedenle, çeşitli analitik yöntemler kullanılarak farklı biyolojik örneklerde valproik asit test prosedürleri önerilmiştir. Bu derlemede, biyolojik örneklerde valproik asidin tayinine yönelik bildirilen analitik metotlar ve bu metotların performans özelliklerine değinilmiştir.

Anahtar Kelimeler

Epilepsi, valproik asit, anti–epileptik, analitik yöntemler

Kaynakça

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