Fetal cinsiyet sağlıklı gebelerde serum plasental alkalen fosfataz seviyelerini etkileyebilir mi?

Yıl 2017, Cilt: 14 Sayı: 2, 111 - 116, 31.08.2017

Hacer Uyanıkoğlu , Sibel Sak , Adnan İncebıyık

Öz

Amaç: Normal term gebeliklerde fetal cinsiyetin maternal
plasental alkalen fosfataz (ALP) seviyesine etkisinin
araştırılması amaçlandı.
Yöntem ve Gereçler: Termde olan 88 sağlıklı gebede
serum plasental ALP ölçümü yapıldı. Bebeklerin cinsiyeti
çalışmaya alınan tüm kadınların doğumları
sırasında belirlendi. Plasental ALP seviyeleri kız ve erkek
doğuran gebe kadınlar arasında karşılaştırıldı.
Bulgular: Kız fetüse sahip gebelerde plasental ALP
düzeyleri daha yüksek olmakla birlikte bu farklılık
istatistiksel olarak anlamlı değildi (p > 0.05).
Sonuç: 38 - 39’uncu gebelik haftalarında fetal cinsiyetin
maternal serum plasental ALP seviyelerini sağlıklı gebe
kadınlarda etkilemediği görüldü.
Anahtar Kelimeler: Amaç: Normal term gebeliklerde fetal cinsiyetin maternal
plasental alkalen fosfataz (ALP) seviyesine etkisinin
araştırılması amaçlandı.
Yöntem ve Gereçler: Termde olan 88 sağlıklı gebede
serum plasental ALP ölçümü yapıldı. Bebeklerin cinsiyeti
çalışmaya alınan tüm kadınların doğumları
sırasında belirlendi. Plasental ALP seviyeleri kız ve erkek
doğuran gebe kadınlar arasında karşılaştırıldı.
Bulgular: Kız fetüse sahip gebelerde plasental ALP
düzeyleri daha yüksek olmakla birlikte bu farklılık
istatistiksel olarak anlamlı değildi (p > 0.05).
Sonuç: 38 - 39’uncu gebelik haftalarında fetal cinsiyetin
maternal serum plasental ALP seviyelerini sağlıklı gebe
kadınlarda etkilemediği görüldü.
Anahtar Kelimeler: Fetal, cinsiyet, plasental alkalen
fosfataz,

Anahtar Kelimeler

Fetal, cinsiyet, plasental alkalen fosfataz

Could fetal gender affect maternal serum placental alkaline phosphatase levels in healthy pregnant women?

Öz

Aim: We aimed to research whether fetal gender affects maternal placental alkaline phosphatase (ALP) levels in uncomplicated pregnancies with late term. Materials and Methods: The serum placental ALP measurement was carried out in 88 healthy pregnant women at 38 - 39 weeks of gestation. Infant sex was determined at the delivery for all women included in this study. Placental ALP levels were compared between pregnant women bearing female and male fetuses. Results: Although placental ALP levels were slightly higher in pregnant women carrying female fetuses than in male bearing pregnant women, this difference was not statistically significant (p > 0.05). Conclusions: Fetal gender was seen not to affect maternal serum placental ALP levels in healthy pregnant women at 38 - 39 weeks of gestation. : 

Anahtar Kelimeler

Fetal, gender;, placental alkaline phosphatase

Kaynakça

• 1. Fishman WH. Perspectives on alkaline phosphatase isoenzymes. Am J Med 1974;56(5):617-50.
• 2. Mazda T, Gyure WL. Assay of alkaline phosphatase isoenzymes by a convenient precipitation and inhibition methodology. Chem Pharm Bull 1988;36(5):1814–8.
• 3. Okesina AB, Donaldson D, Lascelles PT, Morris P. Effect of gestational age on levels of serum alkaline phosphatase isoenzymes in healthy pregnant women. Int J Gynecol Obstet 1995;48(1):25–9.
• 4. Obiekwe BC, Chard T. Placental proteins in late pregnancy, relation to fetal sex. J Obstet Gynaecol 1983;3:163–4.
• 5. Lorzadeh N, Kazemirad S. The effects of fetal gender on serum human chorionic gonadotropin and testosterone in normotensive and preeclamptic pregnancies. J Pregnancy 2012;2012:874290. doi: 10.1155/2012/874290.
• 6. Wojcicka Bentyn J, Czajkowski K, Sienko J, Grymowicz M, Bros M. Extremely elevated activity of serum alkaline phosphatase in gestational diabetes: a case report. Am J Obstet Gynecol 2004;190(2):566–7.
• 7. Vongthavaravat V, Numberger MM, Balodimos N, Blanchette H, Koff RS. Isolated elevation of serum alkaline phosphatase level in an uncomplicated pregnancy: a case report. Am J Obstet Gynecol 2000;183(2):505–6.
• 8. Hatzmann W, Becker R, Maeso M, Hoffken H. Excessive rise in plasma alkaline phosphatase in the last trimester of pregnancy. Geburtshilfe Fraunheilkd 1994;54(6):378–80.
• 9. Adeniyi FA, Olatunbosun DA. Origins and significance of the increased plasma alkaline phosphatase during normal pregnancy and pre-eclampsia. Br J Obstet Gynaecol 1984;91(9):857–62.
• 10. Bashiri A, Katz O, Maor E, Sheiner E, Pack I, Mazor M. Positive placental staining for alkaline phosphatase corresponding with extreme elevation of serum alkaline phosphatase during pregnancy. Arch Gynecol Obstet 2007;275:211-4.
• 11. Paul L, Wolf MD. Clinical significance of increased or decreased serum alkaline phosphatase isoenzymes. Clin Lab Med 1986;6(3):525–32.
• 12. Gol M, Sisman AR, Guclu S, Altunyurt S, Onvural B, Demir N. Fetal gender affects maternal serum total and placental alkaline phosphatase levels during pregnancy. Eur J Obstet Gynecol Reprod Biol 2006;128(1-2):253-6.
• 13. Agrawal YP, Ylikangas P, Parviainen MT, Penttila IM. Flow cytometric method to measure urea-resistant alkaline phosphatase from blood neutrophils for use in the prenatal screening of Down’s syndrome. Prenat Diagn 1994;14(12):1141–9.
• 14. Moawad AH, Goldenberg RL, Mercer B, et al. The Preterm Prediction Study: the value of serum alkaline phosphatase, alpha-fetoprotein, plasma corticotropinreleasing hormone, and other serum markers for the prediction of spontaneous preterm birth. Am J Obstet Gynecol 2002;186(5):990–6.
• 15. Yaron Y, Lehavi O, Urtreger A, Gull I, Lessing J. Maternal serum hCG is higher in the presence of a female fetus as early as week 3 postfertilization. Hum Reprod 2002;17(2):485–9.
• 16. Vergnes HA, Denier CJ, Brisson-Lougarre A, Grozdea JG. Fetal sex and variations in kinetic properties of neutrophil alkaline phosphatase during the second trimester of normal pregnancy. Early Hum Dev 1998;51(1):1–5.
• 17. Steier J, Myking O, Bergsjo P. Correlation between fetal sex and human chorionic gonadotropin in peripheral maternal blood and amniotic fluid in second and third trimester normal pregnancies. Acta Obstet Gynecol Scand 1999;78(5):367–71.