The effects of taurine on central nervous system

Yıl 2020, Cilt: 9 Sayı: 2, 214 - 219, 23.12.2020

Gül Yarım , Ayris Gökçeoğlu , Murat Yarım

https://doi.org/10.31196/huvfd.751318

Öz

Taurine is a neuroprotective amino acid which regulates gene expression of neural stem and precursor cells, modulating inflammatory pathways in the central nervous system, suppressing apoptosis, antioxidant effect and controlling cell volume and water content of neurons. Taurine suppresses endoplasmic stress-mediated apoptosis through the ionotropic taurine receptor and the metabotropic taurine receptor. Due to its neuroprotective effect, taurine is successfully used in the prophylaxis and treatment of neurodegenerative disorders. This review aims to present current scientific information of the effects of taurine on the central nervous system and its use in alleviating central nervous system disorders.

Anahtar Kelimeler

Central nervous system, Neuroprotective, Taurine

Taurinin merkezi sinir sistemi üzerindeki etkileri

Öz

Taurin, nöral kök ve prekürsör hücrelerin gen ekspresyonunu düzenleyen, merkezi sinir sistemindeki enflamatuar yolları modüle eden, apoptozu baskılayan, antioksidan etkili ve nöronların hacmini ve su içeriğini kontrol eden nöroprotektif bir amino asittir. Taurin, iyonotropik taurin reseptörü ve metabotropik taurin reseptörü aracılığıyla endoplazmik stres aracılı apoptozu baskılamaktadır. Nöroprotektif etkisi nedeniyle taurin nörodejeneratif bozuklukların profilaksisinde ve tedavisinde başarıyla kullanılmaktadır. Bu derlemenin amacı, taurinin merkezi sinir sistemi üzerindeki etkilerini ve taurinin merkezi sinir sistemi hasarlarını hafifletmede kullanımını konusunda güncel bilimsel bilgiyi sunmaktır.

Anahtar Kelimeler

Merkezi sinir sistemi, Nöroprotektif, Taurin

Kaynakça

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