Examination of the obesogenic effects of Bisphenol-A

Year 2018, Volume: 2 Issue: 2, 185 - 194, 15.08.2018

Hakan Çelebi , Gülden Gök , Özlem Güllü Oğuzhan Gök

Abstract

The prevalence of obesity among people
has increased dramatically in recent years in all the world. It is not enough
to explain this increasing trend only with people's lifestyle, eating habits
and cultural differences. Some chemicals, which are taken into the human body,
especially through the food chain and are considered to be endocrine
disruptors, affect the frequency of obesity. Endocrine disrupting chemicals
(EDCs) are compounds that cause hormone disruption and elimination of the
functions of these hormones. Bisphenol-A (BPA) is one of the most intensive
chemicals in human life and is generally called 2,2-bis (4-hydroxyphenyl)
propane. 70% of the BPA in the world is used in polycarbonate plastics and 30%
in epoxy resins. Due to the widespread usage of it, BPA reaches solid and
liquid wastes in terrestrial and aquatic ecosystems in large quantities.
Considering the high production capacity of BPA and its different application
areas, it is claimed that significant amount of BPA enters the environment.
Studies show that the rate of being exposed to BPA has an increasing tendency.
In the literature, the rate of availability in drinking water and the data on
the reproductive system were only included in the researches related to BPA.
Therefore, this study aimed to observe the obesogenic role of BPA in the
development of obesity, which is the current health problem of the world. BPA
is an endocrine disrupting chemical known to have in vitro effects on glucose
metabolism and adipose tissue. In a limited number of clinical and
epidemiological studies, BPA has been shown to be associated with diabetes and
obesity. For this purpose, the current literature related to this issue has
been reviewed and the effects of BPA on obesity have been compiled both in the
world and in our country.

Keywords

Bisphenol A, Endocrine system, Obesity, Polycarbonate plastic

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